Physical Sciences Division
Published October 22, 2020 | Version v1
Patent Open

PROXIMITY-DEPENDENT SPLIT RNA POLYMERASES AS A VERSATILE BIOSENSOR PLATFORM

Creators

  • 1. University of Chicago

Contributors

Patent applicant:

Description

A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.

Files

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Additional details

Identifiers

Patent application number
US 201716305298 A
Patent number
US 2020/0332371 A1
Other
oai:uchicago.tind.io:8654

Dates

Patent filed
2017-06-06

UChicago Information

Division(s)
Physical Sciences Division
Department(s)
Chemistry