Published July 25, 2013
| Version v1
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METHODS AND COMPOSITIONS RELATED TO IMMUNIZING AGAINST STAPHYLOCOCCAL LUNG DISEASES AND CONDITIONS
- 1. University of Chicago
Contributors
Patent applicant:
Description
Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing Hla to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a Hla with reduced toxicity, represented by a recombinant mutant form of Hla (HlaH35L) in which histidine 35 is convened to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
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Additional details
Identifiers
- Patent number
- US 201313742155 A
- Patent application number
- US 2013/0189249 A1
- Other
- oai:uchicago.tind.io:7880
Dates
- Patent filed
-
2013-01-15