Published May 22, 2014 | Version v1
Patent Open

MODULATION OF CELL BARRIER DYSFUNCTION

Description

The invention provides prophylactic and therapeutic methods for administering a μ-opioid receptor antagonist, e.g., N-methylnaltrexone or a salt thereof, to treat cell barrier diseases and disorders, such as endothelial and epithelial cell barrier diseases and disorders, e.g., sepsis. Methods of reducing at least a symptom of sepsis and the risk of developing sepsis are also provided.

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Additional details

Identifiers

Patent number
US 201314061331 A
Patent application number
US 2014/0142133 A1
Other
oai:uchicago.tind.io:8459

Dates

Patent filed
2013-10-23

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Surgery, Anesthesia and Critical Care