gene_callers_id	cor_nitrates	cor_chlorophyll	cor_temperature	cor_salinity	cor_phosphate	cor_silicon	cor_depth	cor_oxygen	pnps	function_COG20_CATEGORY	function_COG20_FUNCTION	function_Pfam	function_KOfam	accession_Pfam
1248	-0.13491197110969663	-0.08462821007008225	-0.4773824644250607	-0.03192983143536031	-0.12375811542401106	-0.10860944275466099	0.06169457864441513	0.3256337268631078	0.021045937639988736	Signal Transduction	Translation elongation factor EF-Tu, a GTPase (TufA) (PDB:1EFU)	Elongation factor Tu GTP binding domain;Elongation factor Tu domain 2;Elongation factor Tu C-terminal domain;50S ribosome-binding GTPase	elongation factor Tu	PF00009.28;PF03144.26;PF03143.18;PF01926.24
1249	0.08482076323599937	-0.12529055390969943	0.2272060522103568	-0.14538216671824286	0.06779463206787406	0.0979588758593249	0.06530224585562712	-0.1936798268842317	0.0646179111947035	Lipid metabolism	Preprotein translocase subunit SecE (SecE) (PDB:5MG3) (PUBMED:29684280)	SecE/Sec61-gamma subunits of protein translocation complex	preprotein translocase subunit SecE	PF00584.21
1250	0.11289707224808818	-0.252241055067978	-0.3352185130811125	0.06528762600245373	0.012985161364453148	-0.01144913973124643	0.1650070078088192	0.13316311320787405	0.012920770742094278	Signal Transduction	Transcription termination/antitermination protein NusG (NusG) (PDB:3EWG) (PUBMED:19500594)	KOW motif;Transcription termination factor nusG	transcription termination/antitermination protein NusG	PF00467.30;PF02357.20
1251	0.012760664590371062	0.08424412979142278	-0.4996250257157254	0.02658585340536316	-0.0405067853912697	-0.12384677239542487	0.09233901779246814	0.3664086066856239	0.011502685575644685	Signal Transduction	Ribosomal protein L11 (RplK) (PDB:2E34)	Ribosomal protein L11, RNA binding domain;Ribosomal protein L11, N-terminal domain	large subunit ribosomal protein L11	PF00298.20;PF03946.15
1252	0.273973143228334	0.08045282116323932	-0.4154876877211073	-0.1041831837415547	0.1938691877939437	-0.07019186439122897	0.11082353424805348	0.22575310672698484	0.04932845724605154	Signal Transduction	Ribosomal protein L1 (RplA) (PDB:3J65)	Ribosomal protein L1p/L10e family	large subunit ribosomal protein L1	PF00687.22
1253	0.0629563885466618	0.07709562051526757	-0.4952277858282428	0.05472503516878675	-0.06939553422982567	-0.1530519288666861	0.0744983174281363	0.33178262475629045	0.026950797563627414	Signal Transduction	Ribosomal protein L10 (RplJ) (PDB:5IT8)	Ribosomal protein L10	large subunit ribosomal protein L10	PF00466.21
1255	0.032600716194672856	0.09312562528218893	-0.2840786400199852	0.07686680532284937	-0.07207897229683945	-0.04736421146393948	0.14838475541161544	0.14485663383207587	0.018716545855255676	Signal Transduction	DNA-directed RNA polymerase, beta subunit/140 kD subunit (RpoB) (PDB:5UAJ)	RNA polymerase beta subunit;RNA polymerase Rpb2, domain 2;RNA polymerase Rpb2, domain 3;RNA polymerase beta subunit external 1 domain;RNA polymerase Rpb2, domain 6;RNA polymerase Rpb2, domain 7	DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	PF04563.16;PF04561.15;PF04565.17;PF10385.10;PF00562.29;PF04560.21
1256	0.03254136995992391	0.13092034313510953	-0.4225771748602928	0.10397388692957404	-0.06545991723347541	-0.08520604338058814	0.058201715141655085	0.3056297139796493	0.018124707725098877	Signal Transduction	DNA-directed RNA polymerase, beta' subunit/160 kD subunit (RpoC) (PDB:1NT9)	RNA polymerase Rpb1, domain 1;RNA polymerase Rpb1, domain 2;RNA polymerase Rpb1, domain 3;RNA polymerase Rpb1, domain 4;RNA polymerase Rpb1, domain 5	DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]	PF04997.13;PF00623.21;PF04983.19;PF05000.18;PF04998.18
1257	0.28093631907962463	-0.007939532434316447	-0.2839773031869318	0.09830259332692987	0.13167637913776076	0.05849151557894633	-0.048400214286649465	0.10962034693480029	0.026124551157537042	Signal Transduction	Ribosomal protein S12 (RpsL) (PDB:4V4H)	Ribosomal protein S12/S23	small subunit ribosomal protein S12	PF00164.26
1258	0.03139461784054267	0.0787505912704151	-0.5465602786866577	0.054172683007536804	-0.07925449147361281	-0.19849912980154075	-0.05580029339273765	0.42312354838329946	0.021985984254615613	Signal Transduction	Ribosomal protein S7 (RpsG) (PDB:4V4H)	Ribosomal protein S7p/S5e	small subunit ribosomal protein S7	PF00177.22
1259	0.45389298933577804	-0.014093628076009144	-0.5376131501891732	-0.0693041432107367	0.3198072080534001	0.04762082944317043	0.16440498837101544	0.13145417699509238	0.02582569633405503	Signal Transduction	Translation elongation factor EF-G, a GTPase (FusA) (PDB:1DAR)	Elongation factor G C-terminus;Elongation Factor G, domain III;Elongation factor G, domain IV;Elongation factor Tu GTP binding domain;Elongation factor Tu domain 2	elongation factor G	PF00679.25;PF14492.7;PF03764.19;PF00009.28;PF03144.26
1260	0.16095127153182381	0.19169850500803062	-0.4536794371479278	0.28778772115695156	-0.08859814154947375	-0.09049801469026472	0.2517435689077629	0.17209873468738443	0.004262747523668718	Signal Transduction	Ribosomal protein S10 (RpsJ) (PDB:4V4H)	Ribosomal protein S10p/S20e	small subunit ribosomal protein S10	PF00338.23
1261	0.2272318660843108	0.011513114099263465	-0.5516846710821428	-0.1373422285384072	0.10863788382301869	-0.05450449929541975	0.008274546168103093	0.30636044141045504	0.035841833007975867	Signal Transduction	Ribosomal protein L3 (RplC) (PDB:1VS6)	Ribosomal protein L3	large subunit ribosomal protein L3	PF00297.23
1262	0.27059481609699376	0.08865395277889918	-0.5784021795085048	0.004807437489988329	0.09840192826850135	-0.0979860860703149	0.10529508424139833	0.28492598543607217	0.02360363140750156	Signal Transduction	Ribosomal protein L4 (RplD) (PDB:1VS6)	Ribosomal protein L4/L1 family	large subunit ribosomal protein L4	PF00573.23
1263	0.3734744838419852	0.09219758970793483	-0.37677727917117415	-0.08499802123601873	0.2862815512288794	0.013478102950220366	0.03459722113737003	0.17309956103311433	0.029686822392877035	Signal Transduction	Ribosomal protein L23 (RplW) (PDB:1VS6)	Ribosomal protein L23	large subunit ribosomal protein L23	PF00276.21
1264	0.3237393925757572	-0.05945766376532777	-0.2990157792742286	-0.2453495717835859	0.3215974032612177	0.049157194417910666	0.04703498538529495	0.1164530807878986	0.020293067197613035	Signal Transduction	Ribosomal protein L2 (RplB) (PDB:1VS6)	Ribosomal Proteins L2, RNA binding domain;Ribosomal Proteins L2, C-terminal domain	large subunit ribosomal protein L2	PF00181.24;PF03947.19
1265	0.09392158850950529	0.11821937395427698	-0.4465065949868731	0.05572561247495315	0.025588773891181745	-0.06849893217612844	0.0568690229402985	0.26165477698316425	0.009123056112123216	Signal Transduction	Ribosomal protein S19 (RpsS) (PDB:4V4H)	Ribosomal protein S19	small subunit ribosomal protein S19	PF00203.22
1266	0.3949405537517081	0.025910588493396156	-0.49933450477717456	-0.09955862124500538	0.275364850746892	0.021366461975631877	0.10839171074979279	0.2074204130860607	0.05134581308253078	Signal Transduction	Ribosomal protein L22 (RplV) (PDB:1VS6)	Ribosomal protein L22p/L17e	large subunit ribosomal protein L22	PF00237.20
1267	-0.35928531529643826	-0.046665623748402434	-0.20418665072739253	0.2264822014785426	-0.3708992724924352	-0.12187691360204675	-3.708160489084838e-4	0.1964994873316285	0.013799529739318623	Signal Transduction	Ribosomal protein S3 (RpsC) (PDB:1VS6)	KH domain;Ribosomal protein S3, C-terminal domain	small subunit ribosomal protein S3	PF07650.18;PF00189.21
1268	-0.11331592224667507	0.18309579421274277	-0.4351636160065564	0.2965221197632861	-0.24677701721571368	-0.20160010535702264	0.34111140260762013	0.2146431664950919	0.020299500136776998	Signal Transduction	Ribosomal protein L16/L10AE (RplP) (PDB:1WKI)	Ribosomal protein L16p/L10e	large subunit ribosomal protein L16	PF00252.19
1270	0.36918959900736154	0.12991739876659772	-0.40537784699761575	-0.06012918930423434	0.16351729471989887	-0.01821604972626678	0.3066420470271061	0.07342399704969538	0.04881259029558807	Signal Transduction	Ribosomal protein S17 (RpsQ) (PDB:4V4H)	Ribosomal protein S17	small subunit ribosomal protein S17	PF00366.21
1271	0.29418501248249046	-0.06599825615497695	-0.4920451711624984	-0.019891553279632147	0.2137264892168771	-0.038058012455206874	0.05115908494909467	0.2379947265049645	0.015083349762256459	Signal Transduction	Ribosomal protein L14 (RplN) (PDB:4V4H)	Ribosomal protein L14p/L23e	large subunit ribosomal protein L14	PF00238.20
1272	-0.33751412779141166	0.1148583126515094	0.11166572251118918	0.3227621908147308	-0.3609966324068579	-0.0637911833543288	0.09353043937344695	-0.003324728110424307	0.05542351446184549	Signal Transduction	Ribosomal protein L24 (RplX) (PDB:1VS6)	Ribosomal proteins 50S L24/mitochondrial 39S L24	large subunit ribosomal protein L24	PF17136.5
1273	0.17826214506727367	-0.03168062881159258	-0.45955754743972194	0.07309230689472954	0.0184349811477241	-0.12893544987781821	0.004456282513106712	0.24619666285966355	0.03866337570485021	Signal Transduction	Ribosomal protein L5 (RplE) (PDB:1VS6)	Ribosomal protein L5;ribosomal L5P family C-terminus	large subunit ribosomal protein L5	PF00281.20;PF00673.22
1274	-0.10777257193594005	-0.11003272972231026	0.5433665655258991	-0.09833094620043788	0.14251861681963446	0.13115436840032288	0.02951311589921423	-0.3331484455506958	0.04456328525406864	Signal Transduction	Ribosomal protein S14 (RpsN) (PDB:4V4H)	Ribosomal protein S14p/S29e	small subunit ribosomal protein S14	PF00253.22
1275	-0.047550399417193814	0.017446514795184824	-0.1922896931379955	0.06961915108393188	-0.09030565927543334	-0.15430050517827137	0.07792430366121263	0.13488222687182777	0.02535756898718499	Signal Transduction	Ribosomal protein S8 (RpsH) (PDB:4V4H)	Ribosomal protein S8	small subunit ribosomal protein S8	PF00410.20
1276	0.07627724228685495	0.14070109762678867	-0.3504846677579193	-0.037035151503939566	0.0053440179432317	-0.09181774186153105	0.05540098578269447	0.26598291662973056	0.017858244713625727	Signal Transduction	Ribosomal protein L6P/L9E (RplF) (PDB:1VS6)	Ribosomal protein L6	large subunit ribosomal protein L6	PF00347.24
1277	0.340296615907742	0.11217225174216654	-0.39660126864541195	-0.03369625942397259	0.18987169215551006	-0.04470208157200131	0.10166849833479796	0.22150741399053114	0.09264802839504226	Signal Transduction	Ribosomal protein L18 (RplR) (PDB:1VS6)	Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast	large subunit ribosomal protein L18	PF00861.23
1278	0.04137764956058917	-0.03124641117739732	-0.6100341786307014	-0.0061079270329958265	-0.08823436452780618	-0.16178525551725517	-0.005137429057612329	0.3570527667962554	0.016308185182953756	Signal Transduction	Ribosomal protein S5 (RpsE) (PDB:4V4H)	Ribosomal protein S5, N-terminal domain;Ribosomal protein S5, C-terminal domain	small subunit ribosomal protein S5	PF00333.21;PF03719.16
1279	0.31826392860313985	-0.051581486910426216	0.08814072670282501	-0.24906402409786196	0.28526774573775016	0.21357715916558584	0.0983409676807315	-0.17277046816212274	0.04567272782127197	Signal Transduction	Ribosomal protein L15 (RplO) (PDB:1VS6)	Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A	large subunit ribosomal protein L15	PF00828.20
1280	-0.030149505676928003	-0.035662848582748125	-0.30742787445022834	-0.0555710956546028	0.054420435462609405	-0.0041340982447607985	0.029323151893553313	0.2949547312723474	0.016942023159043192	Lipid metabolism	Preprotein translocase subunit SecY (SecY) (PDB:1RH5)	SecY translocase	preprotein translocase subunit SecY	PF00344.21
1281	0.15886679155585268	0.024621204077532526	0.22815044602760648	0.14526391492138208	0.08751621899450587	0.0763789662352714	0.05921652340627438	-0.23355914380733428	0.16344045288487324	Cell motility	Adenylate kinase or related kinase (Adk) (PDB:1AK2)	AAA domain;AAA domain;AAA domain;Adenylate kinase;Deoxynucleoside kinase;Thymidylate kinase	adenylate kinase [EC:2.7.4.3]	PF13207.7;PF13238.7;PF13671.7;PF00406.23;PF01712.20;PF02223.18
1282	0.08175875429933538	0.005802062113844773	0.015580284314440519	-0.1193146682594434	0.1258007882958042	0.07421165435963901	0.08687591770151039	0.005785583563301091	0.024830961875595758	Signal Transduction	Ribosomal protein S13 (RpsM) (PDB:4V4H)	Ribosomal protein S13/S18	small subunit ribosomal protein S13	PF00416.23
1283	0.0999418220678036	0.09796387873248465	-0.30404418452011134	0.042425331681608	0.12492458532777309	-0.061929224347614054	0.057021374597330254	0.23347233193645642	0.023362432141572385	Signal Transduction	Ribosomal protein S11 (RpsK) (PDB:4V4H)	Ribosomal protein S11	small subunit ribosomal protein S11	PF00411.20
1284	-0.030266570213187866	-0.09967308432536061	-0.2974801278921016	0.09284906985396521	-0.13689759317116343	-0.01982887764262207	0.14841200803214305	0.17204755589714876	0.018391554199436885	Signal Transduction	DNA-directed RNA polymerase, alpha subunit/40 kD subunit (RpoA) (PDB:4KN7)	RNA polymerase Rpb3/RpoA insert domain;Bacterial RNA polymerase, alpha chain C terminal domain;RNA polymerase Rpb3/Rpb11 dimerisation domain	DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	PF01000.27;PF03118.16;PF01193.25
1285	0.13402675407299822	0.10667363800663118	-0.43694103568430515	0.05858041786208234	-0.02242365607175912	0.043336039312410785	0.2534909166353881	0.1763570549544497	0.04435599171651236	Signal Transduction	Ribosomal protein L17 (RplQ) (PDB:1GD8)	Ribosomal protein L17	large subunit ribosomal protein L17	PF01196.20
1286	-0.06894180105945918	-0.05941083941513382	-0.1879547249787801	0.038113207450279345	-0.07469805558485454	0.008599668479314137	0.033384359973968554	0.1104878465736249	0.06431410553170085	Signal Transduction	Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific (RluA) (PDB:2I82)	RNA pseudouridylate synthase;S4 domain	23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]	PF00849.23;PF01479.26
1287	0.11748396822600785	0.08226494778704566	-0.46849593999794187	0.059439682637302566	0.07495513750114492	-0.12380485852757774	0.07926397731821504	0.2522741053826593	0.10453454342982302	Energy production and conversion	Lipoate-protein ligase B (LipB) (PDB:2QHT) (PUBMED:19798051)	Biotin/lipoate A/B protein ligase family	lipoyl(octanoyl) transferase [EC:2.3.1.181]	PF03099.20
1288	0.1874725931732583	0.1458353167377092	-0.4205821336113671	0.014470421120836983	0.09634858959585345	-0.056283829729925086	0.16351869994975662	0.2551010095241009	0.019518093653968133	Lipid metabolism	Mg/Co/Ni transporter MgtE (contains CBS domain) (MgtE) (PDB:2YVX)	CBS domain;Divalent cation transporter;MgtE intracellular N domain	magnesium transporter	PF00571.29;PF01769.17;PF03448.18
1289	0.07157474011308768	0.033869911717074055	0.32024561348621405	-0.06747911491682233	0.027464642238655	0.22527241238947257	0.06744080250203577	-0.18789370406670786	0.1959750814080619	Energy production and conversion	Panthothenate synthetase (PanC) (PDB:1DIN) (PUBMED:17968677)	Pantoate-beta-alanine ligase	pantoate--beta-alanine ligase [EC:6.3.2.1]	PF02569.16
1294	-0.11352548229199826	0.02917150415097891	-0.052067617648708396	0.07202661807239469	-0.05771190646986822	-0.14973039788946843	0.09323648854554935	0.11195601182084587	0.03652495271454649	General Functional Prediction only	DNA topoisomerase IA (TopA) (PDB:1CY0)!!!Uncharacterized C-terminal domain of topoisomerase IA	DNA topoisomerase;Toprim domain;Toprim domain;Topoisomerase C-terminal repeat;Topoisomerase DNA binding C4 zinc finger	DNA topoisomerase I [EC:5.6.2.1]	PF01131.21;PF01751.23;PF13662.7;PF13368.7;PF01396.20
1295	0.17183761644647264	0.005023889459567045	0.04110641987599865	-0.017045793467310704	0.0987204805568645	-0.016887310625908453	0.056332123513302065	-0.128593371800684	0.13203653753979996	Replication and repair	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase (PlsY) (PDB:5XJ5) (PUBMED:29684280)	Glycerol-3-phosphate acyltransferase	acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]	PF02660.16
1296	-0.05536724267861258	0.2205571507525596	-0.4238220740490615	0.16770882429648906	-0.12312660752830844	-0.1770230780003343	0.08222913954313445	0.3777291462171594	0.026790038065904947	Cell motility	Dihydroorotase or related cyclic amidohydrolase (AllB) (PDB:1J79)	Amidohydrolase family;Amidohydrolase family;Dihydro-orotase-like	dihydroorotase [EC:3.5.2.3]	PF01979.21;PF07969.12;PF12890.8
1297	0.29494608699129105	0.08540697788512179	-0.30587286978145944	-0.13416171603877805	0.2443389628459455	-0.02819062215374935	0.008233731069370281	0.17101351953285482	0.014898278317366556	Cell motility	Aspartate carbamoyltransferase, catalytic subunit (PyrB) (PDB:1NBE)	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	PF00185.25;PF02729.22
1298	-0.4975071888696045	-0.06717516024873091	0.40306784566594034	0.19312966388405817	-0.3473930488879977	-0.02432383968541622	-0.1097581066487628	-0.10701443551976146	0.11239976895969742	Signal Transduction	YqgF/RuvX protein, pre-16S rRNA maturation RNase/Holliday junction resolvase/anti-termination factor (YqgF) (PDB:1IV0) (PUBMED:25545592;26817626)	Holliday junction resolvase	putative holliday junction resolvase [EC:3.1.-.-]	PF03652.16
1300	0.35117630518366555	0.04634546409951316	-0.4901144948379224	1.597409447128001e-5	0.1761271024021647	0.05865616128027685	0.2858652098473426	0.14683150355477215	0.0363265336528985	Signal Transduction	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase (GatA) (PDB:3H0L)	Amidase	aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7];amidase [EC:3.5.1.4]	PF01425.22
1301	0.29093591699472804	0.09113565514813458	-0.49706396191967755	-0.03816605981628577	0.16507259370574162	0.030098396063367814	0.04953768821485216	0.25802961386304496	0.022514720153894448	Signal Transduction	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (GatB) (PDB:3H0M)	GatB/GatE catalytic domain;GatB domain	aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	PF02934.16;PF02637.19
1302	0.2528285051484086	-0.02797619060369948	0.2516446139917562	-0.20283065115703294	0.24646841886291215	0.329312604827415	0.19281592486279647	-0.2989540843276351	0.11466304574717458	Signal Transduction	tRNA 5-hydroxyU34 O-methylase TrmR/YrrM (TrmR) (PDB:1H1D) (PUBMED:29982645)	Methyltransferase domain;O-methyltransferase;Methyltransferase domain	caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]	PF13578.7;PF01596.18;PF13847.7
1303	0.32031082652318027	0.047436087617092726	-0.13892814614721827	-0.13674868056904313	0.2985664470181192	-0.0171410451772992	0.02964154644357163	0.05216874751866011	0.09690187160383246	Signal Transduction	tRNA U34 5'-hydroxylase TrhO, rhodanese family (TrhO) (PDB:4F67) (PUBMED:31253794)	Rhodanese-like domain;UPF0176 acylphosphatase like domain	UPF0176 protein	PF00581.21;PF17773.2
1305	0.09749511799624526	0.17274543944781562	-0.4032566838194561	-0.10064729247852201	-0.06463658819126297	-0.04155171893108965	0.09924934402981145	0.2526976451751379	0.11246703130072697	General Functional Prediction only	Endonuclease YncB, thermonuclease family (YncB)	Staphylococcal nuclease homologue	micrococcal nuclease [EC:3.1.31.1]	PF00565.18
1306	0.196549597850396	0.14061361949842366	-0.3073244425405704	-0.02100550409332869	0.03402205351661647	-0.15734978860511062	0.004677829576880971	0.1337481876672538	0.17494506048889288	RNA processing and modification	Sarcosine oxidase gamma subunit (SoxG)	Sarcosine oxidase, gamma subunit family	sarcosine oxidase, subunit gamma [EC:1.5.3.1]	PF04268.13
1307	-0.36718918988195476	-0.06901584665885496	0.17641967667074285	0.12224514682248536	-0.26669210962752044	0.07081071124757442	-0.09190615098418957	-0.012369912505585993	0.059377634232460466	RNA processing and modification	Glycine cleavage system protein T (aminomethyltransferase) (GcvT) (PDB:2GAH) (PUBMED:25433025;25505271)!!!NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase (FadH2) (PDB:1VRQ)	FAD binding domain;FAD dependent oxidoreductase;2Fe-2S iron-sulfur cluster binding domain;Aminomethyltransferase folate-binding domain;Glycine cleavage T-protein C-terminal barrel domain;Glucose inhibited division protein A;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase;Sarcosine oxidase A3 domain	sarcosine oxidase, subunit alpha [EC:1.5.3.1]	PF00890.25;PF12831.8;PF13510.7;PF01571.22;PF08669.12;PF01134.23;PF13450.7;PF07992.15;PF13738.7;PF17806.2
1309	0.2560079520403419	-0.0345509284567713	-0.7474793508457881	3.6721688392609423e-4	0.01980435083143052	-0.007129978603913313	0.1799775366819563	0.3162591535013971	0.019717934075233798	RNA processing and modification	Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;NAD(P)-binding Rossmann-like domain	sarcosine oxidase, subunit beta [EC:1.5.3.1]	PF01266.25;PF13450.7
1312	0.04956845633774391	0.1000289407501953	-0.19863672955417605	0.12154863429000456	0.04948082744321938	0.06484343305661776	0.18269530811455328	0.12904873316539056	0.06431419382951323	Energy production and conversion	Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) (MltE) (PDB:153L)	Transglycosylase SLT domain	soluble lytic murein transglycosylase [EC:4.2.2.-]	PF01464.21
1313	0.2561640170709165	0.0245243117959159	0.0424276543048325	-0.37318484558486126	0.36810627282118635	0.03230055094458148	-0.003648269172191718	-0.02029526503358484	0.04346362008961966	RNA processing and modification	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase (DapA) (PDB:2R91) (PUBMED:27574185)	Dihydrodipicolinate synthetase family	4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	PF00701.23
1314	0.044108224473511495	0.06568617546469004	-0.24613220779914344	0.15088942907640854	-0.027027383561057303	-0.17342944288088707	0.04437331489957135	0.19498058810280303	0.04426234007854271	Inorganic ion transport and metabolism	tmRNA-binding protein (SmpB) (PDB:1J1H) (PUBMED:26251518)	SmpB protein	SsrA-binding protein	PF01668.19
1315	-0.2132234588971252	-0.3584089754024104	-0.017164895473082014	0.027268653530530956	-0.269256258386975	-0.020433669973252817	0.10703502052552707	-0.03174382685381434	0.16607573590500732	Energy production and conversion	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) (FolK) (PDB:1CBK)	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]	PF01288.21
1316	0.16909033876306945	0.03155087299378567	-0.6116030689026035	-0.04512847170842759	0.08356331898110511	-0.07050136481447093	0.04586429577267801	0.3730309400518523	0.025498379810929842	Function Unknown	(p)ppGpp synthase/hydrolase, HD superfamily (SpoT) (PDB:1TDJ)	ACT domain;HD domain;HD domain;Region found in RelA / SpoT proteins;TGS domain	NA	PF13291.7;PF01966.23;PF13328.7;PF04607.18;PF02824.22
1317	-0.050835652069325894	-0.02549409369493581	-0.21262389608396698	-0.011600366743113839	3.116374505377662e-4	-0.19207342661334775	0.048993370861491366	0.2505227620515957	0.05463818895436417	Cell motility	Orotate phosphoribosyltransferase (PyrE) (PDB:4WML)	Phosphoribosyl transferase domain	orotate phosphoribosyltransferase [EC:2.4.2.10]	PF00156.28
1318	0.017455014020700578	0.026105346390701667	-0.18438286949335472	0.043472792144242996	0.00679225196902303	-0.1481448354478045	0.16206506475575821	0.11439705653206257	0.11073173651032396	Energy production and conversion	Pyridoxine 5'-phosphate synthase PdxJ (PdxJ) (PDB:1HO1)	Pyridoxal phosphate biosynthesis protein PdxJ	pyridoxine 5-phosphate synthase [EC:2.6.99.2]	PF03740.14
1319	-0.3538616650264501	0.01246636721928375	0.10528306234810739	0.2398038180851473	-0.2626485239191577	-0.05919973144626758	-0.059510355965356775	0.0434543160656448	0.15405745306602595	Replication and repair	Phosphopantetheinyl transferase (holo-ACP synthase) (AcpS) (PDB:1F7L)	4'-phosphopantetheinyl transferase superfamily	holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	PF01648.21
1320	0.3266666085239954	0.12191476648954981	-0.16921554308825001	-0.15907085748903824	0.3470176432837481	0.06849846107977402	0.016218482297351195	0.07886110339613653	0.03903857915189775	Lipid metabolism	Signal peptidase I (LepB) (PDB:1B12) (PUBMED:1925027)	Signal peptidase, peptidase S26	signal peptidase I [EC:3.4.21.89]	PF10502.10
1321	0.019155009126592123	0.15665434032833966	0.1519522014913104	-0.1548993038676598	0.08084026214040048	0.16561718586046822	-0.05463635083939355	0.010245227656806799	0.058554079436411596	Signal Transduction	dsRNA-specific ribonuclease (Rnc) (PDB:1DI2)	Double-stranded RNA binding motif;Ribonuclease III domain;Ribonuclease-III-like	ribonuclease III [EC:3.1.26.3]	PF00035.27;PF00636.27;PF14622.7
1322	0.1420005706108651	0.036919589030155	0.09210973349093567	-0.19998243116724806	0.21577353954135708	0.052064546309362254	-0.06254327783586461	0.005846267989575635	0.054335161929625106	General Functional Prediction only	Recombinational DNA repair protein RecO (RecF pathway) (RecO) (PDB:1U5K)	Recombination protein O C terminal;Recombination protein O N terminal	DNA repair protein RecO (recombination protein O)	PF02565.16;PF11967.9
1323	-0.2326693431453189	-0.22890086995117503	0.15144936491688665	0.04176826065330784	-0.2966722675829316	0.014194252522142702	-0.06278116999172256	-0.04442794458148124	0.06538745794724053	Energy production and conversion	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase (HemB) (PDB:1I8J)	Delta-aminolevulinic acid dehydratase	porphobilinogen synthase [EC:4.2.1.24]	PF00490.22
1324	-0.12157830397669857	-0.18182674170825233	0.2902291439016291	0.0014507603666065868	-0.0969991038990075	0.12521619288702232	0.13190976398283738	-0.25419955258496857	0.04565100414819215	Inorganic ion transport and metabolism	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily (LpxO2)	Aspartyl/Asparaginyl beta-hydroxylase	NA	PF05118.16
1325	0.22610117658453951	-0.1758257655045886	-0.060290809141460074	-0.08396006793341997	0.17539697537995114	0.11662106463535832	0.006079447087119489	-0.11296561042598814	0.10731583327059731	Energy production and conversion	Ribose 5-phosphate isomerase RpiB (RpiB) (PDB:1NN4)	Ribose/Galactose Isomerase	ribose 5-phosphate isomerase B [EC:5.3.1.6]	PF02502.19
1326	0.2549086624968147	0.055674267981798094	-0.519101795263228	0.03816647267634667	0.008501407023833365	-0.12685445706046844	0.19851430841271392	0.19936257515451114	0.019391217539136807	RNA processing and modification	Glycine/serine hydroxymethyltransferase (GlyA) (PDB:1BJ4)	Aminotransferase class I and II;DegT/DnrJ/EryC1/StrS aminotransferase family;Serine hydroxymethyltransferase	glycine hydroxymethyltransferase [EC:2.1.2.1]	PF00155.22;PF01041.18;PF00464.20
1327	0.459895970421161	0.058415411988684045	-0.07599461041357371	-0.3106997645452637	0.38982834009615075	0.15261335938084966	0.05706079023361319	-0.06068243696264341	0.022085774771325378	Signal Transduction	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains (NrdR)	ATP cone domain	transcriptional repressor NrdR	PF03477.17
1328	0.34155555540270705	0.11639488725930007	-0.18837307848471396	-0.10120735577722036	0.3090984054963667	0.014087676764807879	0.07684536554317672	0.06407663444085829	0.11387942523253465	Energy production and conversion	Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain (RibD1) (PDB:2O7P)!!!Pyrimidine reductase, riboflavin biosynthesis (RibD) (PDB:2O7P)	Cytidine and deoxycytidylate deaminase zinc-binding region;MafB19-like deaminase;RibD C-terminal domain	diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	PF00383.24;PF14437.7;PF01872.18
1329	0.4550140219486327	-0.03623222881383147	-0.13115847685531143	-0.038922406041040976	0.3348028307506439	0.04945599348247013	0.17588171463312458	-0.14599877649927528	0.04899784959965483	Energy production and conversion	Riboflavin synthase alpha chain (RibC) (PDB:1I8D)	Lumazine binding domain	riboflavin synthase [EC:2.5.1.9]	PF00677.18
1330	-0.008198905603199334	0.11976685477458641	-0.3270189610701373	0.08706840463408629	-0.07455795576786355	0.12249908997611934	0.09387967218442084	0.18786634749101683	0.028357171494806623	Energy production and conversion	3,4-dihydroxy-2-butanone 4-phosphate synthase (RibB) (PDB:1G57)!!!GTP cyclohydrolase II (RibA) (PDB:2BZ0)	3,4-dihydroxy-2-butanone 4-phosphate synthase;GTP cyclohydrolase II	3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	PF00926.20;PF00925.21
1331	0.2063297744966326	0.014249325180359805	-0.012770938954060427	0.09102252814823021	0.1020814006138246	-0.0049391988001191425	0.031169898719564347	-0.042221366409747677	0.08825264519436844	Energy production and conversion	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain) (RibE) (PDB:1C2Y)	6,7-dimethyl-8-ribityllumazine synthase	6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	PF00885.20
1332	0.14461523858346792	0.11642507998457718	-0.41292869957357803	0.10429682502312349	0.04889124898690011	-0.04895805188754051	0.06592611438566547	0.24358382643121126	0.04287286661071427	Signal Transduction	Transcription antitermination protein NusB (NusB) (PDB:1EY1) (PUBMED:21652641)	NusB family	NA	PF01029.19
1333	0.10765793207465234	0.06952032319187024	0.3408912183274581	-0.14522718328601336	0.24793510493857643	0.06926638774357215	-0.06577199655596545	-0.22417120750239372	0.13582143836716168	Energy production and conversion	Thiamine monophosphate kinase (ThiL) (PDB:5CC8)	AIR synthase related protein, N-terminal domain	thiamine-monophosphate kinase [EC:2.7.4.16]	PF00586.25
1334	0.06565617656935971	0.07009542425137821	-0.3173801064134398	0.11632329136227691	0.043655592138331444	-0.030401562832061593	0.18324788996164185	0.14066436131006335	0.01838930208132966	Amino Acid metabolis and transport	Na+ or H+-translocating membrane pyrophosphatase (OVP1) (PDB:4A01) (PUBMED:11342551)	Inorganic H+ pyrophosphatase	K(+)-stimulated pyrophosphate-energized sodium pump	PF03030.17
1337	0.06317920107422709	0.03762223082289786	-0.5528199523264201	-0.00867545822255769	-0.042435336944616125	-0.1572553591790119	0.09619933018566217	0.3494944584771961	0.013919866211074676	Signal Transduction	Ribosomal protein L32 (RpmF) (PDB:1VS6) (PUBMED:17114934)	Ribosomal L32p protein family	large subunit ribosomal protein L32	PF01783.24
1338	0.2577247246162656	-0.049706596423479736	-0.002027812919809643	-0.13474522948089007	0.24205331623280985	0.23145195278820108	0.0650203537220395	-0.13389074816381955	0.042983707549390786	Replication and repair	Acyl-ACP:phosphate acyltransferase (fatty acid/phospholipid biosynthesis) (PlsX) (PDB:2GK3) (PUBMED:18992246)	Fatty acid synthesis protein	phosphate acyltransferase [EC:2.3.1.274]	PF02504.16
1339	0.03896208159205972	0.013919617716029169	0.2087317645887379	-0.1267151039869952	0.07085933220816233	0.1370292653381434	-0.0017506647492801738	-0.11701226648307014	0.06262062343913871	General Functional Prediction only	Bacterial nucleoid DNA-binding protein IHF-alpha (HimA) (PDB:1B8Z)	Bacterial DNA-binding protein	integration host factor subunit alpha	PF00216.22
1340	0.3200103639691113	0.10510180872374864	-0.29331106520615746	-0.014588962566029722	0.22644692509103712	0.09495745893322328	0.1302326251869347	0.08556845922212555	0.11631081296393478	Signal Transduction	DNA-binding transcriptional regulator, MerR family (SoxR) (PDB:2VZ4)	MerR HTH family regulatory protein	NA	PF13411.7
1341	0.25395026872707427	0.19365935278347357	-0.14347971215416375	-0.10399171744313132	0.19905540033803787	0.01799108123767764	0.024720711371034286	0.07535844101571659	0.012638385371042261	Signal Transduction	Ribosomal protein L33 (RpmG) (PDB:1VS6)	Ribosomal protein L33	large subunit ribosomal protein L33	PF00471.21
1342	0.07046096873290364	0.11384107511010982	0.22636621854477473	-0.12434412858334654	0.16155518783986209	0.10512884685680536	-0.11408669923902591	-0.08003224237104281	0.0354290394958294	RNA processing and modification	Chorismate mutase (PheA) (PDB:1ECM)	Chorismate mutase type II	NA	PF01817.22
1343	-0.24369638127943924	-0.19420012433325684	0.032747819661733096	0.008157482259657376	-0.09717619668493457	0.02959429778371248	-0.1884907917001889	0.02636297323703784	0.1672656732622392	Energy production and conversion	Heme A synthase (CtaA) (PDB:6A2J)	Cytochrome oxidase assembly protein	cytochrome c oxidase assembly protein subunit 15	PF02628.16
1345	-0.16564810951429162	0.07481128821893966	-0.49375039499861956	0.23326849517776457	-0.27325031728325594	-0.15847572622590128	-0.02070699507206864	0.3552481975222184	0.030125180485241616	Signal Transduction	Ribosomal protein L13 (RplM) (PDB:1VS6)	Ribosomal protein L13	large subunit ribosomal protein L13	PF00572.19
1346	0.04654203660888184	-0.26719548298245255	-0.32223994213080975	-0.12436684067929886	0.04605753234732125	-0.10898532401275055	0.1294425603097094	0.07025142923777307	0.041775697726943714	Signal Transduction	Ribosomal protein S9 (RpsI) (PDB:4V4H)	Ribosomal protein S9/S16	small subunit ribosomal protein S9	PF00380.20
1347	-0.3095011883942399	0.12370554539158884	0.09169276887493376	0.15567289025225128	-0.3193402976936044	0.030127452734357817	-0.051457599175541525	0.08496796882862566	0.10240086696551431	RNA processing and modification	N-acetyl-gamma-glutamylphosphate reductase (ArgC) (PDB:3DR3)	Semialdehyde dehydrogenase, NAD binding domain;Semialdehyde dehydrogenase, dimerisation domain	N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	PF01118.25;PF02774.19
1348	0.4320689035410751	0.1567692721997869	0.08474160970365857	-0.22648480151805878	0.43919010947425946	0.17434469538210334	0.01310811770409542	-0.16345508603924014	0.25011140835433604	NA	NA	NA	NA	NA
1349	0.15600089919215138	0.18272424490739506	-0.20393140128341117	-0.05546407828559424	0.1404911726825343	-0.12268253284286902	-0.07708965760944732	0.17116014092533033	0.03859392272082308	RNA processing and modification	Homoserine dehydrogenase (ThrA) (PDB:5AVO) (PUBMED:29124164)	ACT domain;Oxidoreductase family, NAD-binding Rossmann fold;Homoserine dehydrogenase;Homoserine dehydrogenase, NAD binding domain	homoserine dehydrogenase [EC:1.1.1.3]	PF01842.26;PF01408.23;PF00742.20;PF03447.17
1351	0.4656537081115743	0.037282290675377076	0.05169595823045991	-0.24161420314831344	0.4955108131441707	0.13951179647968037	-0.022311948183778584	-0.11560308758541492	0.017951321835010952	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	S-adenosylmethionine uptake transporter	PF00892.21
1353	-0.14299515711621064	0.06038755406063993	0.33716935969718465	0.010162090494789947	-0.1427049066568662	-0.0011079940113393407	-0.16165729056898076	-0.15987004065806149	0.07483339681434487	General Functional Prediction only	Site-specific recombinase XerD (XerD) (PDB:1A0P)	Phage integrase family;Phage integrase, N-terminal SAM-like domain	NA	PF00589.23;PF02899.18
1359	-0.08760881762840987	0.057092847194303756	-0.47748798271252335	0.06455715438071492	-0.14332394891176586	-0.10252755896995959	-0.03173695066879607	0.3646108552397066	0.031325785580111926	NA	NA	ETC complex I subunit conserved region	NADH dehydrogenase (ubiquinone) Fe-S protein 4	PF04800.13
1362	0.07043532200623466	-0.2028582126641194	0.35166780386165825	-0.15260479422117385	0.14020098502454573	0.11056057219841996	-0.14642123280842612	-0.2988833538097275	0.12351528888977677	NA	NA	zinc-ribbon domain;zinc-ribbon domain	NA	PF13717.7;PF13719.7
1363	0.24560547734112304	0.03656312946549487	-0.5147520842294272	-0.05746591205036167	0.20356076756256522	-0.06563875156470178	0.07566617356905625	0.2936968893562318	0.024113420315652886	Amino Acid metabolis and transport	Na+/H+ antiporter NhaA (NhaA) (PDB:1ZCD) (PUBMED:25746996)	Na+/H+ antiporter 1	Na+:H+ antiporter, NhaA family	PF06965.13
1366	-0.2585364333017457	-0.024345560303397	-0.5108441034686917	0.25235873101749345	-0.33734407257712823	-0.39465779768815396	0.08433076999878389	0.4298779478216576	0.07121413838964141	Energy production and conversion	3'->5' ssDNA/RNA exonuclease TatD (TatD) (PDB:1J6O) (PUBMED:10747959;25114049)	TatD related DNase	TatD DNase family protein [EC:3.1.21.-]	PF01026.22
1367	-0.05885392984426483	-0.12571231149264853	0.08462828756654857	0.02426300920837339	0.030882707015640557	0.06572520975853233	0.055521954493151365	0.006802779399112583	0.08776437191443796	Signal Transduction	Methionyl-tRNA synthetase (MetG) (PDB:1A8H)	tRNA synthetases class I (I, L, M and V);tRNA synthetases class I (C) catalytic domain;tRNA synthetases class I (M)	methionyl-tRNA synthetase [EC:6.1.1.10]	PF00133.23;PF01406.20;PF09334.12
1368	0.075997423126919	-0.3673358039332228	0.15231952533741253	-0.1417142395151022	0.21477445989753288	0.009165864659713377	-0.11374534365307495	-0.16396961369903687	0.14791408469072734	General Functional Prediction only	DNA polymerase III, delta prime subunit (HolB) (PDB:1A5T)	ATPase family associated with various cellular activities (AAA);DNA polymerase III, delta subunit	NA	PF00004.30;PF13177.7
1369	0.021260734332718467	0.013951027171798918	0.12533451704024628	-0.03608075762452372	0.008290861538312887	-0.037856980921861454	-0.009769021554188047	-0.026242341145442886	0.09602993869978231	Cell motility	Thymidylate kinase (Tmk) (PDB:3LV8)	Thymidylate kinase	dTMP kinase [EC:2.7.4.9]	PF02223.18
1370	0.32015869258686447	0.05039284380859171	-0.26292707722004993	-0.10719535417337042	0.27268381714735757	0.10994855460738268	0.03917222218438061	0.0307489815596084	0.06643581997181473	Energy production and conversion	D-alanyl-D-alanine carboxypeptidase (DacC) (PDB:1HD8)	Beta-lactamase enzyme family;Penicillin-binding protein 5, C-terminal domain;D-alanyl-D-alanine carboxypeptidase	serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	PF13354.7;PF07943.14;PF00768.21
1371	0.1838410639523516	0.17266112984050302	-0.42690664158379676	0.11696486428442349	-0.05916018764681204	-0.10790549188488156	0.18897538054089183	0.21347634376866004	0.12444323191823832	NA	NA	SPOR domain	NA	PF05036.14
1372	0.27021470528644836	0.02676594398234558	-0.21067033406092867	-0.03914580419423754	0.18752380635801377	0.06423467393276279	0.14998574237261394	0.01595589619059763	0.07398686419921431	Energy production and conversion	Membrane-bound lytic murein transglycosylase B (MltB) (PDB:1D0K)	Transglycosylase SLT domain	membrane-bound lytic murein transglycosylase B [EC:4.2.2.-]	PF13406.7
1373	-0.03352581457861249	0.07873707303519205	-0.2053400678062752	0.056434598043936024	-0.068619223613386	-0.03223095767705806	0.06814460826737474	0.16570132802129403	0.051128814339671785	Carbohydrate metabolism and transport	Membrane protein RarD, contains two EamA domains, drug/metabolite transporter family (RarD) (PUBMED:26335199)	EamA-like transporter family	chloramphenicol-sensitive protein RarD	PF00892.21
1374	-0.08112052511251366	-0.07512362641181598	-0.24789726934316159	-0.09603757329768557	0.05385314385875689	-0.14983393413282153	-0.038007457610451746	0.24442033453243067	0.12232018347508346	Inorganic ion transport and metabolism	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module (SdhE) (PDB:1PUZ)	Flavinator of succinate dehydrogenase	NA	PF03937.17
1375	-0.11954019358127115	0.056321341025348054	-0.028832221603723576	0.04258017008015859	-0.07257766123804936	-0.09668718251909184	0.10210501025873384	0.07359664266961198	0.08135797175865812	General Functional Prediction only	RecG-like helicase (RecG) (PDB:1GM5)	DEAD/DEAH box helicase;Helicase conserved C-terminal domain;RecG wedge domain;Type III restriction enzyme, res subunit	ATP-dependent DNA helicase RecG [EC:3.6.4.12]	PF00270.30;PF00271.32;PF17191.5;PF04851.16
1378	-0.1358167112931969	-0.19949523599532465	0.38402452006312293	0.043822485228745274	-0.07530491000628882	0.12105364506319713	-0.042583429579725544	-0.26998841759927533	0.044987644813987634	Signal Transduction	Queuine/archaeosine tRNA-ribosyltransferase (Tgt) (PDB:1XW8) (PUBMED:15805528)	Queuine tRNA-ribosyltransferase	queuine tRNA-ribosyltransferase [EC:2.4.2.29]	PF01702.19
1379	0.2170444932323387	0.04240144421748483	-0.3856201373179252	-0.09786355310521094	0.16515249361971016	-0.11344790851053621	-0.004122249653338259	0.23111454027896783	0.04107823120056981	Inorganic ion transport and metabolism	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family (PpiB) (PDB:4DGD)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	PF00160.22
1380	0.29809897329139723	0.05401282508359572	-0.21299651536096695	-0.16254625049200058	0.291616839944518	0.037603247972245034	0.10725392825021349	0.060161948328525394	0.03903788634766506	Energy production and conversion	Phosphopantetheine adenylyltransferase (CoaD) (PDB:3F3M)	Cytidylyltransferase-like	pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	PF01467.27
1381	0.23598108433574466	0.09954462332466113	-0.27763394354291837	0.024857064495902085	0.18005930163228667	-0.07313533156433606	0.12486236705571832	0.1337497891740308	0.02691094554196262	General Functional Prediction only	DNA gyrase/topoisomerase IV, subunit A (GyrA) (PDB:1SUU)	DNA gyrase C-terminal domain, beta-propeller;DNA gyrase/topoisomerase IV, subunit A	DNA gyrase subunit A [EC:5.6.2.2]	PF03989.14;PF00521.21
1382	0.17201193460272676	0.21623099761445452	-0.18100539911990352	-0.1555853723137412	0.12059794601760326	0.006398382718063331	0.08820980804542256	0.09045282857527182	0.03265033764160504	General Functional Prediction only	Single-stranded DNA-binding protein (Ssb) (PDB:1EQQ)	Single-strand binding protein family	single-strand DNA-binding protein	PF00436.26
1383	0.22810561116561842	0.06233061757212191	-0.43809688452546547	-0.08223312372191274	0.16050158549106258	-0.05004767510324793	0.14339309614072576	0.24164539035537452	0.017990150152367212	General Functional Prediction only	Excinuclease UvrABC ATPase subunit (UvrA) (PDB:2R6F)	AAA ATPase domain;P-loop containing region of AAA domain;ABC transporter;RecF/RecN/SMC N terminal domain;UvrA DNA-binding domain;UvrA interaction domain;Viral (Superfamily 1) RNA helicase	excinuclease ABC subunit A	PF13191.7;PF13555.7;PF00005.28;PF02463.20;PF17755.2;PF17760.2;PF01443.19
1385	0.19845414094942848	0.10034518360027087	-0.06149081569797565	-0.12193112567174222	0.17866699321429047	0.04309973863122071	0.09590598504893416	0.016890190798808713	0.023589041582340934	Lipid metabolism	Preprotein translocase subunit SecF (SecF) (PDB:2FYH) (PUBMED:28830929)	Protein export membrane protein;SecD/SecF GG Motif	preprotein translocase subunit SecF	PF02355.17;PF07549.15
1386	0.2864668527171635	0.10034754377942284	-0.16196462580578336	-0.1461008016315361	0.2803245278482918	0.03859498612657259	0.09302127278514206	0.058347712071097756	0.03436658403923038	Lipid metabolism	Preprotein translocase subunit SecD (SecD) (PDB:3AQP) (PUBMED:26100040)	MMPL family;Protein export membrane protein;SecD/SecF GG Motif	preprotein translocase subunit SecD	PF03176.16;PF02355.17;PF07549.15
1387	0.27648333216891074	0.12665662121246357	-0.24662360243548886	-0.03254936298926289	0.15394523341938113	-0.12242364706089273	0.05505857148689361	0.12477764968939287	0.015011385047146998	Lipid metabolism	Protein translocase subunit YajC (YajC)	Preprotein translocase subunit	preprotein translocase subunit YajC	PF02699.16
1388	0.16088598911802995	0.06776094147666474	-0.012623534178530045	-0.1182503261484763	0.1979887545200657	-0.020340268442921725	-0.021710157010812782	0.03624606179405541	0.0487951499581099	Signal Transduction	Seryl-tRNA synthetase (SerS) (PDB:1SER)	Seryl-tRNA synthetase N-terminal domain;tRNA synthetase class II core domain (G, H, P, S and T)	seryl-tRNA synthetase [EC:6.1.1.11]	PF02403.23;PF00587.26
1389	0.29069320801857174	-0.026658429768913864	-0.49467504345018054	-0.06342200267483966	0.2659170859571102	-0.015617881149211268	0.17839619716731842	0.18367574745247878	0.028640693563207597	Lipid metabolism	Twin-arginine protein secretion pathway component TatC (TatC) (PDB:4B4A)	Sec-independent protein translocase protein (TatC)	sec-independent protein translocase protein TatC	PF00902.19
1390	0.07361817174525022	0.09348410096912539	-0.4153246426579954	-0.12589631627408993	0.09593989395326101	-0.05533379742651942	0.02313622724405195	0.3034888266023743	0.038959549516195464	NA	NA	mttA/Hcf106 family	sec-independent protein translocase protein TatB	PF02416.17
1391	-0.03484656751669835	0.07417249446518616	-0.387623410375327	0.05211553744395492	-0.037396024383070194	-0.0412312040171677	-0.09061437359398399	0.3338706977170593	0.03008273601421769	Lipid metabolism	Twin-arginine protein secretion pathway components TatA and TatB (TatA) (PDB:2L16)	mttA/Hcf106 family	sec-independent protein translocase protein TatA	PF02416.17
1392	-0.03881539728891495	0.026269585176523436	-0.20873694428584938	0.020222785080198345	-0.08500926210874185	7.444167057230825e-4	-0.011340742303146915	0.15936196853255705	0.043146400529930226	Signal Transduction	Chromosome segregation and condensation protein ScpB (ScpB) (PDB:1T6S)	Segregation and condensation complex subunit ScpB	segregation and condensation protein B	PF04079.17
1393	0.23426870503083247	0.013882415608659972	-0.2205295616723466	-0.07695186920013652	0.1949548871309708	-0.025918318283203748	0.09391569869191822	0.06538573545498226	0.02345838018909809	General Functional Prediction only	Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family (ScpA) (PDB:3W6J)	Segregation and condensation protein ScpA	segregation and condensation protein A	PF02616.15
1394	0.3744405394099302	0.019513163046753414	0.022315651502527272	-0.43308890840593045	0.44720108776747103	0.09749138523421785	-0.09911290744744457	-0.04562139112301146	0.0945865828980717	Energy production and conversion	Periplasmic beta-glucosidase and related glycosidases (BglX) (PDB:2X40)	Glycosyl hydrolase family 3 N terminal domain	beta-N-acetylhexosaminidase [EC:3.2.1.52]	PF00933.22
1395	0.3271916618338795	-0.020430530230719782	-0.2214855680277115	-0.058108369488012686	0.27487302253677115	-0.030094699013939595	0.08352731903056951	0.039166614422470554	0.06178102825956312	NA	NA	NA	NA	NA
1396	0.2442838828545761	-0.016689019016016406	-0.163830668414387	-0.164878853302206	0.3569686152871864	0.06519673559821475	0.06545587000493129	0.05072779023131025	0.0596336981625674	Signal Transduction	Arginyl-tRNA synthetase (ArgS) (PDB:1BS2)	Arginyl tRNA synthetase N terminal domain;DALR anticodon binding domain;tRNA synthetases class I (I, L, M and V);tRNA synthetases class I (R);tRNA synthetases class I (M)	arginyl-tRNA synthetase [EC:6.1.1.19]	PF03485.17;PF05746.16;PF00133.23;PF00750.20;PF09334.12
1397	0.16260822747976067	0.02804219108815269	0.0725007988743115	-0.17366668283278033	0.27669348230239454	0.05669297296080452	0.0074675291305892405	-0.03211162312064317	0.04762682660916841	Cell motility	dGTP triphosphohydrolase (Dgt) (PDB:6OI7)	HD domain;Phosphohydrolase-associated domain	dGTPase [EC:3.1.5.1]	PF01966.23;PF13286.7
1398	0.1194270253929669	0.07656818267425744	-0.5904846970040069	0.04910261054819051	-0.01750209714292236	-0.18740618961034308	0.054159672172915	0.38504125593930255	0.01678977922923979	Inorganic ion transport and metabolism	Fe-S cluster assembly iron-binding protein IscA (IscA) (PDB:1R94)	Iron-sulphur cluster biosynthesis	NA	PF01521.21
1399	0.05410737826259156	0.14586395438053049	-0.2983698973787297	-0.035772627646443775	-0.001753614231108714	-0.1806991483695126	-0.13233725619377634	0.2856244293934054	0.0335570883591083	General Functional Prediction only	Exonuclease III (XthA) (PDB:1AKO)	Endonuclease/Exonuclease/phosphatase family	exodeoxyribonuclease III [EC:3.1.11.2]	PF03372.24
1400	0.3533613165002027	0.11599355764944341	-0.13462568239618086	-0.13866993414884995	0.3214045020935635	0.008296484630471421	0.0587333095272729	0.014829489982772778	0.025168589704459295	Amino Acid metabolis and transport	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family (AllD) (PDB:1NXU)	Malate/L-lactate dehydrogenase	delta1-piperideine-2-carboxylate reductase [EC:1.5.1.21]	PF02615.15
1422	0.3283898861457143	-0.2324290743881564	-0.07963546103208137	-0.1723385927600859	0.32237767412005763	0.04971446444776315	0.10211795838983787	-0.07256922040063232	0.06133399807943654	Energy production and conversion	Mannose-6-phosphate isomerase, cupin superfamily (ManC) (PDB:1IPJ)!!!Mannose-1-phosphate guanylyltransferase (CpsB) (PDB:2QH5)	Mannose-6-phosphate isomerase;Nucleotidyl transferase;MobA-like NTP transferase domain	mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]	PF01050.19;PF00483.24;PF12804.8
1423	-0.22596371478163157	0.1985218797180365	-0.1867781189993862	0.022110481090685224	-0.22732363494045482	-0.07931939619619482	-0.003572016507795117	0.27586001488047596	0.028447695327819152	RNA processing and modification	Dihydroxyacid dehydratase/phosphogluconate dehydratase (IlvD) (PDB:2GP4)	Dehydratase family	dihydroxy-acid dehydratase [EC:4.2.1.9]	PF00920.22
1424	0.1797999357243486	0.005491053623428731	-0.3520099872147826	-0.006607273901648474	0.006161663005312213	-0.1809573995550027	0.16624777542359284	0.039717197549984005	0.04110922521358499	Signal Transduction	Valyl-tRNA synthetase (ValS) (PDB:1GAX)	Anticodon-binding domain of tRNA ligase;tRNA synthetases class I (I, L, M and V);tRNA synthetases class I (C) catalytic domain;tRNA synthetases class I (M);Leucyl-tRNA synthetase, Domain 2;Valyl tRNA synthetase tRNA binding arm	valyl-tRNA synthetase [EC:6.1.1.9]	PF08264.14;PF00133.23;PF01406.20;PF09334.12;PF13603.7;PF10458.10
1427	0.18017617469340425	-0.16114921144815492	0.116791605875144	-0.006118500762191234	0.14078446224137067	0.18374190839511997	-0.09298090406938857	-0.3263190986921094	0.014047675547237085	Signal Transduction	Transcriptional regulator, contains XRE-family HTH domain (HipB) (PDB:1ADR)	Helix-turn-helix domain;Helix-turn-helix;Helix-turn-helix domain;Pou domain - N-terminal to homeobox domain	putative transcriptional regulator	PF12844.8;PF01381.23;PF13560.7;PF00157.18
1428	-0.09943945153408176	0.05830446849722126	-0.3149685746612742	0.12758265135327157	-0.18399189111299868	-0.1384362868587684	0.1906770691062209	0.23967243972447635	0.02266920618768252	RNA processing and modification	ABC-type polar amino acid transport system, ATPase component (GlnQ) (PDB:4YMS)	AAA domain, putative AbiEii toxin, Type IV TA system;Predicted ATPase of the ABC class;ABC transporter	general L-amino acid transport system ATP-binding protein [EC:7.4.2.1];polar amino acid transport system ATP-binding protein [EC:7.4.2.1];nonpolar-amino-acid-transporting ATPase [EC:7.4.2.2]	PF13304.7;PF09818.10;PF00005.28
1433	0.1589293846208008	0.15192588243888175	-0.30039977522839645	-0.017472434230088717	0.13494307988473686	-0.09149672684422747	0.010487334710035379	0.24346402999720357	0.030604257734116055	Lipid metabolism	Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain (TrkA) (PDB:4XTT) (PUBMED:23815639;25957408;31868587;32095817)	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain;NADP oxidoreductase coenzyme F420-dependent;Oxidoreductase family, NAD-binding Rossmann fold;NAD binding domain of 6-phosphogluconate dehydrogenase;Putative NAD(P)-binding;NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase;Saccharopine dehydrogenase NADP binding domain;Shikimate / quinate 5-dehydrogenase;TrkA-C domain;TrkA-N domain;UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	trk system potassium uptake protein	PF02737.19;PF03807.18;PF01408.23;PF03446.16;PF13241.7;PF01210.24;PF00070.28;PF07992.15;PF03435.19;PF01488.21;PF02080.22;PF02254.19;PF03721.15
1436	0.16044549558887528	0.18046732764249324	-0.14848085277226877	-0.04828330107114579	0.10462854801713037	0.01852372242316194	-0.018012002341587265	0.14864119989960886	0.09898624238247342	Replication and repair	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) (PDB:1GX1)!!!2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) (PDB:1H3M)	Cytidylyltransferase;2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;YgbB family	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:2.7.7.60 4.6.1.12]	PF02348.20;PF01128.20;PF02542.17
1437	0.06759800948921312	0.10659526560600392	0.42033643983456703	-0.05489897503389787	0.12808993119216602	0.11715288322261504	-0.05513699962327211	-0.19033313068211727	0.0616405197105039	Replication and repair	Phosphatidylglycerophosphatase A (PgpA) (PDB:1RFZ)	Phosphatidylglycerophosphatase A	phosphatidylglycerophosphatase A [EC:3.1.3.27]	PF04608.14
1438	-0.11719776541893098	-0.05155059050239538	0.06609054374584432	0.2773429531697174	-0.3239666435016244	-0.0299582479708575	0.22989469308589466	-0.13300663734795015	0.10201320751956292	Energy production and conversion	Nicotinamide mononucleotide (NMN) deamidase PncC (PncC) (PDB:2A9S)	Competence-damaged protein	NA	PF02464.18
1441	0.03172822057772344	0.05449688108335062	0.061964664018546264	-0.07801043209765525	0.04001541500966531	0.12088776314816076	-0.12574203316494698	0.09607846538507557	0.091410995643852	NA	NA	Septum formation initiator	NA	PF04977.16
1442	0.17914734158694678	0.09220511388159068	-0.17895957741661883	-0.027555500802216474	0.13514486816248028	-0.021698821519988417	0.1214816457968286	0.06162741255051651	0.03273102226248053	Energy production and conversion	Enolase (Eno) (PDB:1E9I)	Enolase, C-terminal TIM barrel domain;Enolase, N-terminal domain	enolase [EC:4.2.1.11]	PF00113.23;PF03952.17
1445	-0.420287941068236	-0.07817670460716905	0.5309905108279873	0.15146380593664333	-0.2082247314725716	0.03462474614485967	-0.049534635640854745	-0.2108639915754511	0.0372242144862268	Cell motility	CTP synthase (UTP-ammonia lyase) (PyrG) (PDB:1S1M)	CTP synthase N-terminus;Glutamine amidotransferase class-I;Peptidase C26	CTP synthase [EC:6.3.4.2]	PF06418.15;PF00117.29;PF07722.14
1446	0.2620593059761655	0.0966772068589651	-0.4433625731188879	-0.03129922268380109	0.15110525198361469	-0.10641881145584531	0.1251423055175898	0.2664748129157158	0.020852706101861594	Lipid metabolism	Protein translocase subunit SecG (SecG) (PDB:2AKH)	Preprotein translocase SecG subunit	preprotein translocase subunit SecG	PF03840.15
1447	0.1528608912399214	-0.009243326249704387	-0.2977908158697472	-0.07859354457177992	0.1868839707532984	-0.1237480510397554	-0.009154581447490004	0.20018416609906442	0.12804080104823112	Energy production and conversion	Triosephosphate isomerase (TpiA) (PDB:1HG3)	Triosephosphate isomerase	triosephosphate isomerase (TIM) [EC:5.3.1.1]	PF00121.19
1449	-0.07704114765973384	0.046427546874871835	0.3696265527335301	0.14390894549592284	-0.012691695074930119	0.1202417916871021	-0.0649837042087148	-0.11016135639710539	0.05511688411151318	RNA processing and modification	Anthranilate/para-aminobenzoate synthases component I (TrpE) (PDB:1I1Q)	Anthranilate synthase component I, N terminal region;chorismate binding enzyme	anthranilate synthase component I [EC:4.1.3.27]	PF04715.14;PF00425.19
1450	-0.2722664926677254	-0.13252434005963512	-0.04779502903693574	0.08639499599576009	-0.10102369789354565	-0.08371525786973504	0.02727210048135956	0.13623723223299136	0.07346094387203549	RNA processing and modification	Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase) (PabA) (PDB:1I1Q)	Glutamine amidotransferase class-I;Peptidase C26	anthranilate synthase component II [EC:4.1.3.27]	PF00117.29;PF07722.14
1451	0.40090059383462234	-0.053525256377048955	-0.45735366858461185	0.018538471369767256	0.21970134512223596	-0.05124983221425427	0.20050984888321788	0.09215667444238325	0.08020557700662649	RNA processing and modification	Anthranilate phosphoribosyltransferase, glycosyltransferase domain (TrpD) (PDB:1KGZ)	Glycosyl transferase family, a/b domain;Glycosyl transferase family, helical bundle domain	anthranilate phosphoribosyltransferase [EC:2.4.2.18]	PF00591.22;PF02885.18
1452	0.23366781414280738	0.1189468416287877	0.009918836626544424	-0.10563061371882039	0.21047653493263846	-0.07655390171432196	0.06905436581116195	-0.04649359925437631	0.08705432438707318	RNA processing and modification	Indole-3-glycerol phosphate synthase (TrpC) (PDB:6BMA)	Indole-3-glycerol phosphate synthase	indole-3-glycerol phosphate synthase [EC:4.1.1.48]	PF00218.22
1453	-0.2765569378166479	0.054124319912888436	-0.39715443814532064	0.31570376129022004	-0.32850484747970743	-0.28189670742612205	0.08526621056211733	0.3953825660236482	0.01615062723282632	Signal Transduction	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) (LexA) (PDB:1AY9)	LexA DNA binding domain;Peptidase S24-like	repressor LexA [EC:3.4.21.88]	PF01726.17;PF00717.24
1454	-0.2999375805503885	-0.10891030123916137	0.34523995244751826	0.10028263745266316	-0.16406433018305072	0.14980826850177498	-0.1341114582408711	-0.12051349072196905	0.06404190601379749	Signal Transduction	Glutamyl- or glutaminyl-tRNA synthetase (GlnS) (PDB:1EUQ)	tRNA synthetases class I (E and Q), catalytic domain	glutamyl-tRNA synthetase [EC:6.1.1.17]	PF00749.22
1467	0.16589649122888742	-0.12190710085693154	0.28142290753126264	-0.04243777082024444	0.1827383526486948	0.20399280717881135	-0.0991231982114816	-0.3096329970608387	0.04130322522716278	Signal Transduction	Ribosomal protein S2 (RpsB) (PDB:4V4H)	Ribosomal protein S2	small subunit ribosomal protein S2	PF00318.21
1468	0.09880686757811177	-0.14627951253930468	0.381631686240658	-0.19102652537789516	0.15178178460551753	0.22746489145837578	-0.10859765534045407	-0.3553758856037705	0.06444787417185811	General Functional Prediction only	DNA polymerase III, alpha subunit (DnaE) (PDB:2HNH)	Bacterial DNA polymerase III alpha NTPase domain;Bacterial DNA polymerase III alpha subunit finger domain;Helix-hairpin-helix motif;PHP domain	DNA polymerase III subunit alpha [EC:2.7.7.7]	PF07733.13;PF17657.2;PF14579.7;PF02811.20
1469	-0.12437095310314818	0.10115577614515779	-0.26035916087119215	0.14727750451126312	-0.14368455084794574	-0.12083847119835328	0.11721731921715371	0.2912306006337302	0.13096130065395417	Energy production and conversion	ABC-type lipoprotein export system, ATPase component (LolD) (PDB:5GKO)	ABC transporter	NA	PF00005.28
1470	0.266156427556576	-0.08878057649939672	0.2565006733904805	-0.07993465962737202	0.29270008989303226	0.3459879259802702	0.20830696574369773	-0.3053833081283359	0.07575672856426863	Energy production and conversion	ABC-type transport system involved in lipoprotein release, permease component LolC (LolE) (PDB:6F49)	FtsX-like permease family;MacB-like periplasmic core domain	lipoprotein-releasing system permease protein;putative ABC transport system permease protein	PF02687.22;PF12704.8
1471	-0.22585706890999838	-0.026248277358948538	0.04232660429122881	0.1292607015812819	-0.23254597769350138	0.08261904635878793	0.16137522564028836	0.019424780362793322	0.04939135633135459	Signal Transduction	Prolyl-tRNA synthetase (ProS) (PDB:5XIF)	Anticodon binding domain;tRNA synthetase class II core domain (G, H, P, S and T)	prolyl-tRNA synthetase [EC:6.1.1.15]	PF03129.21;PF00587.26
1472	0.032312035381577404	0.19488599885105581	-0.3280428519799298	3.0187577898641634e-4	0.008753502231003903	-0.042063972190870366	0.002785264581586463	0.2832137941279118	0.05130998473414201	Nucleotide metabolism and transport	Predicted secreted protein	Protein of unknown function (DUF1467)	NA	PF07330.13
1473	0.24109014098072357	0.10725370044475968	-0.38299506926290605	0.03555351489876769	0.19854152206172837	-0.028308589527951192	0.17950999208464954	0.24215336603169846	0.02232668425102767	Signal Transduction	mRNA degradation ribonuclease J1/J2 (RnjA) (PDB:3T3N)	Metallo-beta-lactamase superfamily;Beta-lactamase superfamily domain;Zn-dependent metallo-hydrolase RNA specificity domain;Ribonuclease J C-terminal domain	ribonuclease J [EC:3.1.-.-]	PF00753.28;PF12706.8;PF07521.13;PF17770.2
1474	-0.4350476118410126	-0.1310599702731688	0.11690292890258647	0.22770670656811626	-0.41286810781907635	-0.12335609593892517	0.06352102716501588	-0.03208069497203211	0.11638951661701998	Energy production and conversion	Pantothenate kinase type III (CoaX) (PDB:2F9T)	Type III pantothenate kinase	type III pantothenate kinase [EC:2.7.1.33]	PF03309.15
1476	0.19524995710872692	0.2072993332334151	-0.25169739519857304	-0.007143155840591249	0.16423855409455634	-0.0030150274180999344	0.05216231299620469	0.18957345082748586	0.044174654936833854	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase subunit 2 (chain N) (NuoN) (PDB:4HE8)	Proton-conducting membrane transporter	NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]	PF00361.21
1477	0.07520171733104326	0.17456524823521694	0.41276134290663224	-0.21723571193603253	0.20059159373810376	0.01884511095764979	-0.21868211118513653	-0.14152648481271737	0.047663526982779654	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase subunit 4 (chain M) (NuoM) (PDB:6HUM)	Proton-conducting membrane transporter	NADH-quinone oxidoreductase subunit M [EC:7.1.1.2];NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]	PF00361.21
1478	0.2396772505472421	0.06423733776545992	-0.2736284600758258	-0.09824212630634915	0.24099240868685193	-7.570008307829928e-4	0.055626975989246305	0.14795281930420928	0.0349631888600946	Amino Acid metabolis and transport	Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit (NuoL) (PDB:3RKO)	NADH dehydrogenase subunit 5 C-terminus;Proton-conducting membrane transporter;NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]	PF06455.12;PF00361.21;PF00662.21
1479	0.29753254926749817	0.1161804029692799	-0.06250308695295909	-0.20680121268616222	0.4292706669821819	0.17283620821030668	-0.0820220046938747	0.03901906066993422	0.012982724306313906	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) (NuoK) (PDB:4HE8)	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]	PF00420.25
1484	0.03681486694823099	0.018639717025411513	-0.3834915161397238	-0.06027166170822663	0.05714294713950007	-0.1690150458766228	0.061911631894963126	0.2996959302031386	0.01821666946474322	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F) (NuoF) (PDB:2FUG)	Respiratory-chain NADH dehydrogenase 51 Kd subunit;NADH-ubiquinone oxidoreductase-F iron-sulfur binding region;SLBB domain	NA	PF01512.18;PF10589.10;PF10531.10
1488	0.1754444533749449	0.0546137372316532	-0.23044096145760246	-0.06080956125891766	0.1645506004333135	-0.10953090519352537	0.07559839520796593	0.15395988610209627	0.016609447235713642	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase 20 kD subunit (chain B) or related Fe-S oxidoreductase (NuoB) (PDB:2FUG) (PUBMED:25941396)	NADH ubiquinone oxidoreductase, 20 Kd subunit	NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]	PF01058.23
1490	0.09164911900465866	0.14226717505004205	-0.21193174325679107	0.026099886653630847	0.042833964559040455	-0.10702250288469253	0.12779388849971474	0.15031115423867186	0.019417479315743082	Inorganic ion transport and metabolism	ATP-dependent Lon protease, bacterial type (Lon) (PDB:6ON2)	ATPase family associated with various cellular activities (AAA);AAA domain (dynein-related subfamily);PrkA AAA domain;Subunit ChlI of Mg-chelatase;Lon protease (S16) C-terminal proteolytic domain;ATP-dependent protease La (LON) substrate-binding domain	ATP-dependent Lon protease [EC:3.4.21.53]	PF00004.30;PF07728.15;PF08298.12;PF13541.7;PF05362.14;PF02190.17
1491	0.06513271469951082	0.08448434498784774	-0.26710988665253926	0.03661943977450263	0.05739020952310254	-0.08825273207714693	0.08916794659640634	0.19377603733848522	0.01412944917992174	Inorganic ion transport and metabolism	ATP-dependent protease Clp, ATPase subunit ClpX (ClpX) (PDB:3HTE)	ATPase family associated with various cellular activities (AAA);AAA domain (Cdc48 subfamily);AAA domain (dynein-related subfamily);C-terminal, D2-small domain, of ClpB protein;MCM P-loop domain;Magnesium chelatase, subunit ChlI;Holliday junction DNA helicase RuvB P-loop domain;Sigma-54 interaction domain;ClpX C4-type zinc finger	ATP-dependent Clp protease ATP-binding subunit ClpX	PF00004.30;PF07724.15;PF07728.15;PF10431.10;PF00493.24;PF01078.22;PF05496.13;PF00158.27;PF06689.14
1492	0.07213841238970062	0.15988268198262767	-0.10234465473927543	-0.17322063520756287	0.11985030504632689	-0.0012748126248822154	-0.05279594345103212	0.1252810583459437	0.02873232158507237	Inorganic ion transport and metabolism	ATP-dependent protease ClpP, protease subunit (ClpP) (PDB:1TG6)	Clp protease	ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	PF00574.24
1493	0.38389083666830776	0.2575887002300979	-0.28363953485665605	-0.07510908723257445	0.2707658727981372	0.12014432901334529	0.10638560463954533	0.09863528990588166	0.066547877789751	Inorganic ion transport and metabolism	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) (Tig) (PDB:5OWI)	FKBP-type peptidyl-prolyl cis-trans isomerase;Bacterial trigger factor protein (TF) C-terminus;Bacterial trigger factor protein (TF)	trigger factor	PF00254.29;PF05698.15;PF05697.14
1505	0.29896518635599045	0.07392424239097915	0.013233235909803258	-0.08787259203150653	0.3225789856921137	4.8010670723155864e-4	0.05291548503961009	-0.09753242165723253	0.05113643536694454	Cell motility	Cytosine/uracil/thiamine/allantoin permease (FUI1) (PDB:2JLN)	Permease for cytosine/purines, uracil, thiamine, allantoin	nucleobase:cation symporter-1, NCS1 family	PF02133.16
1506	0.1039026341043415	-0.061222330554888155	-0.41644416089423897	0.011287790573144151	-0.05938387858258318	0.04461744861456048	0.14802499459388446	0.1708416897397349	0.021064922003784833	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, large permease component (FcbT3)	Tripartite ATP-independent periplasmic transporter, DctM component	C4-dicarboxylate transporter, DctM subunit	PF06808.13
1507	0.056879533168676916	0.0395085438567426	0.09176330696945939	-0.12531299832020906	0.09537062006653634	-0.08344396530665849	-0.05725994023473111	0.02718317388393706	0.06015637971449608	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, small permease component (FcbT2)	Tripartite ATP-independent periplasmic transporters, DctQ component	TRAP-type transport system small permease protein	PF04290.13
1510	0.014962489992441081	0.0018466007882219926	0.06452489699595974	0.0034603204668976675	0.04064866266798355	-0.0961665877222812	0.020896899126586238	0.030285500604355232	0.04952121229461771	Lipid metabolism	Tellurite resistance membrane protein TerC (TerC)	Integral membrane protein TerC family	NA	PF03741.17
1511	0.148844455853479	0.0844055714347062	-0.15476297237264097	-0.07667787298630954	0.11945427090371262	-0.15106330048734834	-0.06981458293585313	0.1642577522206638	0.02499909208619782	Replication and repair	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family (FabG) (PDB:6L1H)	short chain dehydrogenase;Enoyl-(Acyl carrier protein) reductase;KR domain	L-xylulose reductase [EC:1.1.1.10]	PF00106.26;PF13561.7;PF08659.11
1512	0.17292401066772048	0.16191182747821994	-0.37625669878975565	-0.02458837144317203	0.02548224656754332	-0.0610146440415263	0.09376371684601738	0.27238440459627644	0.05059144439475722	Energy production and conversion	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain (NlpD) (PDB:2GU1)	Peptidase family M23	NA	PF01551.23
1520	-0.3234874398317497	0.06555853352474048	0.36318937912630933	0.13919702348236962	-0.16409296045488067	0.10521259301026623	-0.008738824812870052	-0.14004507771239127	0.0350597662185502	RNA processing and modification	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme (IlvB) (PDB:1BFD)	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;Thiamine pyrophosphate enzyme, central domain;Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	sulfoacetaldehyde acetyltransferase [EC:2.3.3.15]	PF02775.22;PF00205.23;PF02776.19
1524	-0.2535471690900212	-0.062018018021639365	0.2463631718094218	0.1896567824112228	-0.23978034276055632	0.10859276865215857	-0.03893637475514973	-0.13941832040255972	0.04110592643478482	Lipid metabolism	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family (TauE) (PUBMED:21183667;22797525)	Sulfite exporter TauE/SafE	uncharacterized protein	PF01925.20
1528	0.4143218512933421	0.012304063078019348	-0.34635509302991174	-0.2163872083930664	0.38681739614352456	0.035458901993149765	0.02495603837798185	0.10803243861888559	0.014309349598844036	Amino Acid metabolis and transport	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit (SdhA) (PDB:1KF6)	FAD binding domain;Fumarate reductase flavoprotein C-term	adenylylsulfate reductase, subunit A [EC:1.8.99.2]	PF00890.25;PF02910.21
1531	-0.29720642772431993	0.1765593789065287	0.12731994344918432	-0.025035989398922015	-0.15086192343326255	-0.06333006714014044	-0.22151140874477368	0.15694547712916684	0.07667996173200878	Cell motility	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family (HinT) (PDB:1AV5) (PUBMED:20934431)!!!5-methylcytosine-specific restriction endonuclease McrA (McrA)	Scavenger mRNA decapping enzyme C-term binding;HIT domain	NA	PF11969.9;PF01230.24
1532	-0.41602895745919155	-0.08977140983479596	0.29653634754558955	0.2635892227544693	-0.3627667919537133	-0.03976327850935038	-0.0463962078673984	-0.08976923904918624	0.14301109953425872	NA	NA	Amino-transferase class IV	NA	PF01063.20
1533	0.010881593314365452	-0.00832551111665704	0.046386045792736946	-0.04768250653879064	0.07906531033338064	0.11197890238710706	-0.07339466030357425	-0.06615751834428661	0.07705305483951617	RNA processing and modification	Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase) (PabA) (PDB:1I1Q)	Glutamine amidotransferase class-I;Peptidase C26	NA	PF00117.29;PF07722.14
1534	0.03085681760260001	-0.029908756673915435	0.03818300004094485	0.1467235133540591	-0.11420602263248805	0.0017752763939443226	0.20303074902408555	-0.12543229920072999	0.04780324889332391	RNA processing and modification	Anthranilate/para-aminobenzoate synthases component I (TrpE) (PDB:1I1Q)	chorismate binding enzyme	NA	PF00425.19
1540	0.10096556921915746	0.012186832613929131	0.12444497476353661	-0.2378039957952947	0.1994129990191727	0.006969564768006373	-0.2751600585177593	0.04492122427982387	0.044946121722575574	Signal Transduction	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain (MnmA) (PDB:2HMA) (PUBMED:25825430)	Asparagine synthase;NAD synthase;Queuosine biosynthesis protein QueC;tRNA methyl transferase	tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	PF00733.22;PF02540.18;PF06508.14;PF03054.17
1541	-0.07933437282270064	-0.03193488263819692	-0.05316102678808098	0.09336969750914507	-0.10535383998850793	0.10976639310989887	0.07701730272834971	-0.08310114959174356	0.0967318982141692	NA	NA	Protein of unknown function (DUF3553)	NA	PF12073.9
1542	0.2909961862883683	-0.02128292387104856	-0.33189679730624394	-0.11024415767047599	0.3059444714162262	-0.012789337235016098	0.025258183939185937	0.13059208832567495	0.117183130668984	Lipid metabolism	3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase (CysQ)	Inositol monophosphatase family	3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	PF00459.26
1543	-0.026762831162721278	0.15549038177251653	0.1877505437908246	0.1006381470521824	-0.06895419088488548	0.02421963708817825	0.0479467470393146	-0.06798681691935646	0.06711312130245231	NA	NA	NA	NA	NA
1544	0.3086161149086651	0.03158206253641741	-0.37572660334982994	-0.19726295489471876	0.26608724804370654	-0.037241083460316876	0.020806471782473614	0.17321813630536834	0.03759519119337567	Inorganic ion transport and metabolism	SOS response regulatory protein OraA/RecX, interacts with RecA (RecX) (PDB:3C1D)	RecX family	regulatory protein	PF02631.17
1545	0.45376744141151093	0.0711968371571309	0.013727445351182876	-0.1924087737095732	0.45931162665070313	0.10786283889620038	-0.022686366167935682	-0.08000572067068215	0.04391772529898221	NA	NA	Domain of unknown function (DUF4281)	NA	PF14108.7
1546	0.3047527109468483	0.09577430375910322	0.0569151048579279	0.022750057705752325	0.15805081165238546	0.16066424598959408	0.22158316197257033	-0.19402555078035022	0.1288416601350225	Function Unknown	2-hydroxychromene-2-carboxylate isomerase (NahD)	DSBA-like thioredoxin domain;Thioredoxin	NA	PF01323.21;PF13462.7
1547	0.3689754372346854	-0.026121757384492936	0.09316202254603008	-0.2543491547028596	0.3946781846983391	0.057551720048971564	-0.04840195388236788	-0.08419266628624891	0.1043566780773422	Lipid metabolism	Rhodanese-related sulfurtransferase (PspE) (PDB:1TQ1)	Rhodanese-like domain	NA	PF00581.21
1548	0.131279827810206	-0.08490524415964118	0.46100577351972477	-0.12855238967293547	0.19956416281243036	0.1335367189105157	-0.12334472882368815	-0.3219719705438129	0.12437097974884195	NA	NA	NA	NA	NA
1552	-0.01931999475585184	-0.05912615496895777	-0.7115540788312165	0.18693545485777197	-0.18525809448314454	-0.20832571368551847	0.21600645242456246	0.43145498041007296	0.008089364452089546	General Functional Prediction only	Bacterial nucleoid DNA-binding protein IHF-alpha (HimA) (PDB:1B8Z)	Bacterial DNA-binding protein	DNA-binding protein HU-beta	PF00216.22
1553	-0.018304895512894975	0.09715482207339039	0.18316584760109994	-0.24284056501265822	0.09993685121326083	-0.041441699566656415	-0.12904577825841343	-0.04036909455520747	0.025625241787463903	Inorganic ion transport and metabolism	Membrane-associated protease RseP, regulator of RpoE activity (RseP)	PDZ domain;PDZ domain;PDZ domain;Peptidase family M50	regulator of sigma E protease [EC:3.4.24.-]	PF00595.25;PF13180.7;PF17820.2;PF02163.23
1556	-0.015232984443029882	0.16674838448235402	-0.4369592928762955	0.0312958501038389	-0.12571292436905002	-0.18360029663574284	0.07397102169521619	0.3592429483478501	0.024851349314427812	General Functional Prediction only	ssDNA abasic site-binding protein YedK/HMCES, SRAP family (SRAP) (PDB:1ZN6) (PUBMED:30554877;31504793)	SOS response associated peptidase (SRAP)	NA	PF02586.15
1559	0.017663780618285895	0.1806863035320915	-0.44433829897014737	-0.10175644285013426	-0.028423286482452754	-0.11626440587708659	0.11865893924722078	0.35890420539102286	0.06804795184858228	Energy production and conversion	Lysophospholipase L1 or related esterase. Includes spore coat protein LipC/YcsK (TesA) (PDB:1BWP)	GDSL-like Lipase/Acylhydrolase;GDSL-like Lipase/Acylhydrolase family	acyl-CoA thioesterase I [EC:3.1.2.- 3.1.2.2 3.1.1.2 3.1.1.5]	PF00657.23;PF13472.7
1562	0.07360618020812049	0.03992291652320473	0.04744091539619784	0.05586011568595223	0.08066057307976865	-0.008551754684243353	0.07018872193821653	-0.02062303822823828	0.09911749124604115	NA	NA	NA	NA	NA
1563	-2.0594633589908815e-4	-0.07728996943437119	0.026101864029227168	-0.03295282711257339	-0.04810788044003603	8.559156442233186e-4	-0.11364877142544665	0.03367592542487211	0.08409075111531586	NA	NA	SOUL heme-binding protein	NA	PF04832.13
1564	-0.22277070977253371	0.11796837984516657	0.04375461920639344	0.09033413082865989	-0.220516838330591	0.06415842979712866	0.03519976605761649	9.654890188215074e-4	0.03443000480476982	NA	NA	NA	NA	NA
1565	0.1704111978927502	0.1490796697433032	-0.10245485144243481	-0.31856913029302	0.2781074758114951	0.019585005461035133	-0.036510637206540124	0.10956647623005061	0.061115315466922754	Lipid metabolism	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family (TauE) (PUBMED:21183667;22797525)	Sulfite exporter TauE/SafE	uncharacterized protein	PF01925.20
1574	-0.15779678054962945	0.19181721995025994	-0.015497089288582885	0.14940158014189392	-0.18335307252550165	0.018404206238905204	0.07203104163195724	0.12434421037249395	0.10104744376327361	RNA processing and modification	Na+/proline symporter (PutP) (PDB:5NVA)	Sodium:solute symporter family	NA	PF00474.18
1575	0.045643079632633525	-0.18131988681542283	0.1105222907989596	0.037565423415644165	0.07949604201449116	-0.11439552771013398	-0.19747298003138794	-0.051480316886585845	0.06965735905915812	NA	NA	NA	NA	NA
1576	0.27733585003313854	0.013540295628540276	-0.46375246378553253	-0.15826073912591107	0.22482515785894808	-0.057257341238753076	0.01963691885432363	0.25660137222156576	0.025582009816224716	NA	NA	Pentapeptide repeats (8 copies);Pentapeptide repeats (9 copies);Pentapeptide repeats (9 copies)	NA	PF00805.23;PF13576.7;PF13599.7
1584	0.19128338069815656	0.05613964884634133	0.0358911697766327	-0.030395942588853444	0.1387143549889529	-0.0030349706463778207	-0.03220428147802167	-0.0024423581024891465	0.0406702687838882	Energy production and conversion	ABC-type glycerol-3-phosphate transport system, periplasmic component (UgpB) (PDB:2Z8D)	Bacterial extracellular solute-binding protein;Bacterial extracellular solute-binding protein	glucose/mannose transport system substrate-binding protein	PF01547.26;PF13416.7
1586	0.42709310375969933	-0.08948298606709874	0.05420331548808238	-0.13700562880375164	0.36859222302652717	0.22928742531409238	0.007047553621457645	-0.24429981295740041	0.02452433201755343	Replication and repair	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family (FabG) (PDB:6L1H)	short chain dehydrogenase;Enoyl-(Acyl carrier protein) reductase;NAD dependent epimerase/dehydratase family;KR domain	2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) [EC:1.1.1.401]	PF00106.26;PF13561.7;PF01370.22;PF08659.11
1587	-0.15002199318460205	0.12273352413514053	0.012691692416907364	0.29493025096247055	-0.15378713785744189	-0.15416278806463352	-0.02516440678509565	0.053661305973921984	0.012940933039406594	Carbohydrate metabolism and transport	TctA family transporter (PUBMED:14499931)	Tripartite tricarboxylate transporter TctA family	putative tricarboxylic transport membrane protein	PF01970.17
1589	0.1893294825831487	-0.010175223649916547	-0.7268860717130226	0.13682508048812975	-0.03559411578116636	-0.12898666126249947	0.10390152328037187	0.40526859790471087	0.02093859396879609	Amino Acid metabolis and transport	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC (TctC) (PDB:2DVZ)	Tripartite tricarboxylate transporter family receptor	putative tricarboxylic transport membrane protein	PF03401.15
1590	0.1656300287858567	-0.19591991870598227	-0.09424285329312873	-0.15638728485157904	0.2115037962359455	0.19583470270959266	0.1904861810701585	-0.10423463327185127	0.034159874415466605	Energy production and conversion	4-hydroxy-L-threonine phosphate dehydrogenase PdxA (PdxA) (PDB:1PS6)	Pyridoxal phosphate biosynthetic protein PdxA	NA	PF04166.13
1593	0.2055083786525701	0.12789392931164642	-0.1873548236071832	-0.062498077634990545	0.16294135078255714	-0.04278357136467097	0.04499559997492338	0.11675562168363454	0.02140199591020996	Replication and repair	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase (AdhE) (PDB:1A4S)	Aldehyde dehydrogenase family	succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]	PF00171.23
1596	0.042637582746605875	0.11880719323690182	0.12280033865821115	-0.15014109005915852	0.015645653257955063	0.08209284784842967	-0.031797551602006015	-0.12843401005627267	0.009418080905252708	NA	NA	NA	NA	NA
1603	0.4979518812899201	-0.03151870506832289	-0.4307370660970051	-0.19227750172960076	0.3600762717912003	-0.005163291360205218	0.11943155503072188	0.07847426001148244	0.020477021277130754	Energy production and conversion	ABC-type glycerol-3-phosphate transport system, periplasmic component (UgpB) (PDB:2Z8D)	Bacterial extracellular solute-binding protein;Bacterial extracellular solute-binding protein	multiple sugar transport system substrate-binding protein	PF01547.26;PF13416.7
1606	-0.2590672301714384	-0.06937014354743658	-0.18168408498037789	0.07759655091859137	-0.29326627443903447	-0.17660529459684432	0.12274865379991466	0.1363517674854769	0.04576917870409471	NA	NA	NA	NA	NA
1616	0.4727454207376992	0.027810274071002075	-0.23039067807009161	-0.13034423099047343	0.42931630831601275	0.06804748755853175	0.039472447519112434	0.0564352296924555	0.04499359975781097	Energy production and conversion	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain (RbsB) (PDB:1BA2)	Periplasmic binding proteins and sugar binding domain of LacI family;Periplasmic binding protein domain	simple sugar transport system substrate-binding protein	PF00532.22;PF13407.7
1617	-0.26630901819271435	0.08965438834774193	0.039366883164316274	0.05693296534489949	-0.17712837428930028	-0.11630024398671547	-0.12866491137908062	0.18517375899319505	0.02032050176419495	Energy production and conversion	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component (AraH)	Branched-chain amino acid transport system / permease component	simple sugar transport system permease protein	PF02653.17
1620	0.08639641330226115	0.08837505470736999	-0.12978657488525924	-0.07404756643204743	0.08253981487040792	-0.04380529706394438	0.010809368040850703	0.1111270637978564	0.05138724833528833	Amino Acid metabolis and transport	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family (AllD) (PDB:1NXU)	Malate/L-lactate dehydrogenase	NA	PF02615.15
1621	-0.2751912301336479	0.07134198082746859	-0.1771745512702707	0.4939553195724803	-0.34195946474126954	-0.23790303095708876	0.17973308210721056	0.11437667677642671	0.12796970662337756	NA	NA	NA	NA	NA
1624	-0.03432464752931538	0.18289986860521418	-0.17451210581306764	-0.06737090714073228	-0.053716665136958615	-0.09132916684320305	0.047814367316541616	0.16725109301668165	0.027553266954543285	Amino Acid metabolis and transport	Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) (Pta) (PDB:1QZT) (PUBMED:28754323)	Phosphate acetyl/butaryl transferase	phosphate butyryltransferase [EC:2.3.1.19]	PF01515.20
1631	0.11802067367165144	0.28716551227512455	0.07855171898608992	-0.11481467014393121	0.032404091747422245	-0.09047249741282079	-0.09597194072483053	0.029193811846726973	0.03695002662381525	RNA processing and modification	Serine acetyltransferase (CysE) (PDB:1T3D)	Bacterial transferase hexapeptide (six repeats);Hexapeptide repeat of succinyl-transferase	serine O-acetyltransferase [EC:2.3.1.30]	PF00132.25;PF14602.7
1632	0.05695990042983336	0.17169691116305325	-0.3710041244755845	0.23912592694307036	-0.09366929329437854	-0.22437085328107614	0.07610273343979312	0.23672886770155335	0.016684461066036747	RNA processing and modification	Cysteine synthase (CysK) (PDB:1FCJ)	Pyridoxal-phosphate dependent enzyme	NA	PF00291.26
1638	0.036100452754329014	0.055880237413223635	0.13552033577344194	0.15935539608639157	0.08958215860080262	0.014030162031759552	0.027355494780892383	-0.03360897829032604	0.07587469508105645	NA	NA	Domain of unknown function (DUF4440);SnoaL-like domain	NA	PF14534.7;PF12680.8
1643	-0.2739984274251758	0.05753136786957718	0.001279949990759858	0.2081495762136432	-0.3040765544187621	-0.029047866405886056	0.07609210304339335	0.08966273412016305	0.05841528619878013	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF924 family (PDB:2I6H)	Bacterial protein of unknown function (DUF924)	NA	PF06041.12
1645	-0.12373349065621646	0.018414993465061907	0.16768580980242534	0.025363771836829533	-0.07142663452323167	0.23448692302635496	0.022233488919987415	-0.06438523632425942	0.06131399186620131	Function Unknown	Taurine dioxygenase, alpha-ketoglutarate-dependent (TauD) (PDB:1DRT)	Taurine catabolism dioxygenase TauD, TfdA family	gamma-butyrobetaine dioxygenase [EC:1.14.11.1]	PF02668.17
1646	0.0786458882154025	-0.029197138748795648	-0.499609923406982	0.024277371548158136	0.027477729861965682	-0.13644565689744984	0.14237358955438473	0.2876155896065806	0.034517259326916926	Amino Acid metabolis and transport	FMN-dependent NADH-azoreductase (AzoR) (PDB:1TIK)	Flavodoxin-like fold;NADPH-dependent FMN reductase	FMN-dependent NADH-azoreductase [EC:1.7.1.17]	PF02525.18;PF03358.16
1647	0.18881521431346496	0.1943743022489989	-0.1108395037140434	0.0424215637572292	0.16470210103417357	-0.04333002729786089	0.15532632681533182	0.04346030863186002	0.04261672129660064	Amino Acid metabolis and transport	Cytochrome c biogenesis protein CcdA (CcdA) (PDB:5VKV)	Cytochrome C biogenesis protein transmembrane region;Cytochrome C biogenesis protein transmembrane region	cytochrome c-type biogenesis protein	PF02683.16;PF13386.7
1649	0.07304027436336755	-0.013284599959154646	-0.16304707142904779	-0.09496444180119584	0.15385446306494646	-0.04387206501065438	0.04947930558769854	0.1760465056130821	0.09786129121076047	Energy production and conversion	Sugar lactone lactonase YvrE (YvrE) (PDB:1E1A)	Two component regulator propeller;SMP-30/Gluconolactonase/LRE-like region	NA	PF07494.12;PF08450.13
1650	0.30292206122659276	0.03336761531554772	0.03457757053126888	-0.020166215983246964	0.2628244232239965	0.14559940688210868	0.15519346682766647	-0.23529726693392827	0.0614863813146529	Energy production and conversion	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily (RspA) (PDB:1BKH)	Enolase C-terminal domain-like;Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	D-galactarolactone cycloisomerase [EC:5.5.1.27]	PF13378.7;PF02746.17
1651	0.30561376281250224	0.02889775178885265	-0.1422771688469846	-0.34523654004704446	0.4012211797540803	0.1069598088635422	-0.07504543841039858	0.09325557866017493	0.07290168038616307	Function Unknown	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) (YcgM) (PDB:1GTT)	Fumarylacetoacetate (FAA) hydrolase family	2,4-didehydro-3-deoxy-L-rhamnonate hydrolase [EC:3.7.1.26]	PF01557.19
1652	0.34036908092293533	0.0884134662969118	-0.008513677249604956	-0.14032865304309727	0.34137198358878273	0.15113992503344542	0.07378553299992607	-0.08084435677648166	0.04275619531045759	Replication and repair	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family (FabG) (PDB:6L1H)	short chain dehydrogenase;Enoyl-(Acyl carrier protein) reductase	2-keto-3-deoxy-L-fuconate dehydrogenase [EC:1.1.1.-]	PF00106.26;PF13561.7
1653	0.20686907132679458	0.03418284455136081	0.2587311786360007	-0.044007359606385625	0.3354888820477846	0.07449857269359292	-0.07987061435906337	-0.1782639332212367	0.0683709219282349	Replication and repair	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase (MmsB) (PDB:1I36)	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain;NADP oxidoreductase coenzyme F420-dependent;NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase;NAD binding domain of 6-phosphogluconate dehydrogenase;Pyridine nucleotide-disulphide oxidoreductase	3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]	PF02826.20;PF03807.18;PF14833.7;PF03446.16;PF00070.28
1654	0.40747682588979944	0.008999017657980826	-0.5119491396723467	-0.14899763280053097	0.307392838735788	0.006343141103536881	0.13238751568008034	0.16949468550890595	0.007325509847416468	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, large permease component (FcbT3)	Tripartite ATP-independent periplasmic transporter, DctM component	C4-dicarboxylate transporter, DctM subunit	PF06808.13
1656	0.4706994478968883	-0.12236378070507313	-0.579390108768122	-0.15156491463543442	0.196060115850142	0.05379651753921533	0.17586297922067914	0.06969277270991292	0.03885642366814959	Energy production and conversion	TRAP-type C4-dicarboxylate transport system, periplasmic component (DctP) (PDB:2CEX)	Bacterial extracellular solute-binding protein, family 7	TRAP-type transport system periplasmic protein	PF03480.14
1659	0.2537401967409989	0.017881119376242184	-0.0010061478982457323	-0.15113533748422608	0.3024101807439923	0.006007739404968966	-0.04065754513055338	0.0016854612001790084	0.027721937993548548	Energy production and conversion	Altronate dehydratase (UxaA) (PDB:6U7L)	D-galactarate dehydratase / Altronate hydrolase, C terminus;SAF domain	altronate hydrolase [EC:4.2.1.7]	PF04295.14;PF08666.13
1660	0.2720128242894096	-0.04981883637709773	-0.035582162094602916	0.08528932563973712	0.2526838103689812	-0.028367268121668305	0.1301889442324056	-0.13462961270286383	0.03725282859637817	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	S-adenosylmethionine uptake transporter	PF00892.21
1667	0.4540349875951693	-0.06985992663203475	-0.2493374625865167	-0.1923976531301953	0.4614587411987949	0.10715580877106345	-0.053699594492546396	0.033055421797652466	0.0324428998352796	NA	NA	Domain of unknown function (DUF4396)	NA	PF14342.7
1668	0.36382005713082677	0.022189381084208894	-0.04451778178404667	-0.2463697691804897	0.4577065592925736	0.05576233062954724	0.05603645304636565	-0.04066584345402537	0.05880108135589867	Carbohydrate metabolism and transport	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II (GloB) (PDB:1QH3) (PUBMED:25670698)!!!Rhodanese-related sulfurtransferase (PspE) (PDB:1TQ1)	Metallo-beta-lactamase superfamily	hydroxyacylglutathione hydrolase [EC:3.1.2.6];sulfur dioxygenase [EC:1.13.11.18]	PF00753.28
1669	0.2836854445296521	0.08511693285813457	-0.1795234146156622	-0.1997053344378204	0.30086161599226086	2.650655864860748e-4	-0.07443204762485248	0.1522045165045455	0.07412336379448096	RNA processing and modification	Branched-chain amino acid transport protein (AzlD2)	Branched-chain amino acid transport protein (AzlD)	NA	PF05437.13
1670	0.27054786854929386	0.06734057512002904	-0.07490371539865182	-0.18867272565947527	0.33138388920279827	-0.004794931312407111	-0.023398986043605734	0.025664923933217544	0.02686638721037658	RNA processing and modification	Predicted branched-chain amino acid permease (azaleucine resistance) (AzlC)	AzlC protein	NA	PF03591.15
1674	-0.33486000576696445	0.05067804603838125	0.025005593176848157	0.28687192214016816	-0.32362546924392877	-0.10665247589465755	-0.0035583172793273977	0.14637158034919046	0.018133683039618435	Signal Transduction	DNA-binding transcriptional regulator, LysR family (LysR) (PDB:2FYI)	Bacterial regulatory helix-turn-helix protein, lysR family;LysR substrate binding domain	LysR family transcriptional regulator, glycine cleavage system transcriptional activator	PF00126.28;PF03466.21
1676	0.1293723823164171	0.09289833205067963	0.06685316442648793	0.13440916553283322	0.03714180491281936	0.13153294534048574	0.23481008708327625	-0.19875571072314246	0.05058447065325914	Energy production and conversion	GTP cyclohydrolase I (FolE) (PDB:1A8R) (PUBMED:19767425;30692671)	GTP cyclohydrolase I	GTP cyclohydrolase IA [EC:3.5.4.16]	PF01227.23
1677	0.2602612695152998	0.08759058682800841	0.0530921466445666	-0.16211935283074008	0.3080796676322838	0.004635103212977282	-0.013083794709301608	-0.04111217552803095	0.026093173424176	RNA processing and modification	Phosphoribosyl-AMP cyclohydrolase (HisI1) (PDB:1ZPS)	Phosphoribosyl-AMP cyclohydrolase	phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]	PF01502.19
1679	0.40905100253812415	-0.011406380483342662	-0.46476128169671443	-0.09915307590319768	0.32406582630853636	0.04331200058516445	0.12077466984162846	0.2089440663004564	0.021841489545883355	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF2237 family (PDB:2LQ3)	Uncharacterized protein conserved in bacteria (DUF2237)	uncharacterized protein	PF09996.10
1680	0.011578050483301388	0.08050482685362899	-0.09094699591459925	-0.07818372974825076	0.020173252778840668	-0.052921248969835334	-0.0435610090601361	0.15369783094107448	0.028288355985922376	Amino Acid metabolis and transport	Dehydrogenase (flavoprotein) (FixC) (PDB:4OPU)!!!Ferredoxin-like protein FixX (FixX)	FAD dependent oxidoreductase;Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S;FAD binding domain;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Thi4 family	electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1]	PF01266.25;PF05187.14;PF00890.25;PF13450.7;PF00070.28;PF01946.18
1681	0.35257828070152986	0.013747224572831765	0.09195179939734621	-0.28960236315267934	0.3546249462151141	0.1941258331606219	-0.030814914235509222	-0.13294294505071022	0.03869741988586289	Amino Acid metabolis and transport	Electron transfer flavoprotein, alpha subunit FixB (FixB) (PDB:1EFP)	Electron transfer flavoprotein domain;Electron transfer flavoprotein FAD-binding domain	electron transfer flavoprotein alpha subunit	PF01012.22;PF00766.20
1682	0.32467048898941575	0.12434641470716111	-0.43939990501993215	-0.08486492663907727	0.16119222841515013	0.06148590788923175	0.19291576016351322	0.16485139562954304	0.02184507690734307	Amino Acid metabolis and transport	Electron transfer flavoprotein, alpha and beta subunits (FixA) (PDB:5OL2)	Electron transfer flavoprotein domain	electron transfer flavoprotein beta subunit	PF01012.22
1683	-0.2085814917429708	0.09753117434608521	-0.3926195975826538	0.12780346124421518	-0.25516331842753803	-0.17278615891419302	0.08240204657855782	0.32702211112243823	0.01817527807070343	RNA processing and modification	Glycine cleavage system protein T (aminomethyltransferase) (GcvT) (PDB:2GAH) (PUBMED:25433025;25505271)!!!Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;FAD binding domain;FAD dependent oxidoreductase central domain;Aminomethyltransferase folate-binding domain;Glycine cleavage T-protein C-terminal barrel domain;FAD-NAD(P)-binding;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase	dimethylglycine dehydrogenase [EC:1.5.8.4]	PF01266.25;PF01494.20;PF16350.6;PF01571.22;PF08669.12;PF13454.7;PF00070.28;PF13738.7
1684	-0.21939052851852694	-0.018894709941644747	-0.057776329816854266	0.2569171666348379	-0.34040741283799175	-0.008901334270896547	0.11120931619415435	0.0028526692135920793	0.07087669856288989	NA	NA	NA	NA	NA
1686	0.4704270727568576	-0.060814388462979006	-0.2734095693798137	-0.08148167125748423	0.4563296699295538	0.1445689679956201	-0.010383316534512127	-0.008700230174563837	0.036259549262579016	NA	NA	BT1 family	NA	PF03092.17
1691	0.28357170578334656	0.11939062290667982	-0.010727686304362641	-0.2002952108552719	0.3429170244899189	0.0756003575002612	-0.01739354163332385	-0.03056154638667792	0.05334870312028498	Replication and repair	Enoyl-CoA hydratase/carnithine racemase (CaiD) (PDB:1DCI)	Enoyl-CoA hydratase/isomerase;Enoyl-CoA hydratase/isomerase	enoyl-CoA hydratase [EC:4.2.1.17]	PF00378.21;PF16113.6
1692	-0.21729087224957	0.19459807330020723	-0.15068418590403712	0.5732410411478975	-0.37953844190011227	-0.16619393149109388	0.2042915516811012	0.10172951815091534	0.0526487618929633	NA	NA	NA	NA	NA
1693	0.03971952070519627	-0.030587699329967813	-0.5215320938023528	0.2989536458631449	-0.11716019027786415	-0.14019294590719125	0.1924937761172999	0.22930409179165398	0.030680271304936512	Lipid metabolism	Adenylylsulfate kinase or related kinase (CysC) (PDB:2GKS)!!!Nicotinamide mononucleotide adenylyltransferase (NadR) (PDB:1LW7)	NA	NA	NA
1698	0.23753819359055392	0.1660486441732551	-0.36055211259504244	0.29674200253101585	-0.029342192568888197	-0.1519145859094625	0.1870344037753238	0.11236856036186472	0.023383968846061164	RNA processing and modification	Methionine synthase I (cobalamin-dependent), methyltransferase domain (MetH1) (PDB:1LT7)	Homocysteine S-methyltransferase	betaine-homocysteine S-methyltransferase [EC:2.1.1.5]	PF02574.17
1703	-0.2827229074026193	0.05337200447852452	0.30059054219357456	0.15971670851013725	-0.215688876068894	0.04173581369261186	0.0106391681489196	-0.030428078771272276	0.042804266383626596	RNA processing and modification	Glycine cleavage system protein T (aminomethyltransferase) (GcvT) (PDB:2GAH) (PUBMED:25433025;25505271)	Aminomethyltransferase folate-binding domain	aminomethyltransferase [EC:2.1.2.10]	PF01571.22
1704	0.41192865926463174	0.15786986553284146	-0.2951731570985933	-0.16340461266704598	0.27666361929598005	0.026115470013792285	0.02264352177530781	0.16288769240174156	0.016298496829604117	NA	NA	NA	NA	NA
1705	0.08192975643313206	0.09064341928951396	-0.008695996120753084	-0.21267450689696146	0.10734461632308637	0.1061631752033274	0.04089114018501874	0.008734571829491436	0.07734217915732407	NA	NA	NA	NA	NA
1706	-0.13348386985231575	0.10655546785307819	0.2749757828763213	0.3205980362283597	-0.10637632594798666	0.0539985809354588	0.044483875978336446	-0.08206137263480918	0.1339949286458455	NA	NA	Protein of unknown function (DUF3726)	NA	PF12525.9
1707	0.02841727549770413	0.01607189611848047	-0.3649407507613053	-0.027304522563302853	-0.028619360153899098	-0.09686429084640863	0.06486920981145347	0.255717859897083	0.05757749152964765	NA	NA	NA	NA	NA
1708	-0.2022228924990785	0.030902632414318922	-0.18661009904054277	0.08921536906577263	-0.15485351162875366	-0.2108080923736302	-0.005808420358202248	0.2828849796126601	0.05696687867274859	Inorganic ion transport and metabolism	Zn-dependent dipeptidase, microsomal dipeptidase homolog (PDB:1ITQ) (PUBMED:14499931)	Membrane dipeptidase (Peptidase family M19)	membrane dipeptidase [EC:3.4.13.19]	PF01244.22
1709	0.2412588335291167	0.023907771030115255	-0.37353636123026174	-0.16592983819513604	0.2890670460790519	-0.03910419767743329	0.038824593080666644	0.18454302674313433	0.11230832010245508	Cell motility	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase (PurE) (PDB:1D7A)	AIR carboxylase	5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	PF00731.21
1710	-0.11602988445506186	-0.03607485548736779	0.11810383535509457	-0.062410151132863925	-0.05918855025935392	0.06600567210163098	-0.11163808154175534	0.057987923511644744	0.07934366873104622	Cell motility	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) (PurK) (PDB:1B6R)	ATP-grasp domain;Phosphoribosylaminoimidazole carboxylase C-terminal domain	5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]	PF02222.23;PF17769.2
1711	0.02283474481054687	0.1712017571315619	-0.14640493596590515	0.10642812412145773	-0.02492833098275503	0.037389294785386745	0.1854173505408727	0.03409193035172694	0.09167714291137788	RNA processing and modification	N-acetylglutamate synthase or related acetyltransferase, GNAT family (ArgA) (PDB:2R98)	Acetyltransferase (GNAT) family;Acetyltransferase (GNAT) domain	putative acetyltransferase [EC:2.3.1.-]	PF00583.26;PF13673.8
1712	0.08592860610421132	0.11479183594509731	0.49154102428605484	0.264445105099881	0.058151337334939227	0.1086280751190249	0.072548903557267	-0.42473585912087347	0.02092269594667865	Signal Transduction	Cold shock protein, CspA family (CspC) (PDB:1C9O)	'Cold-shock' DNA-binding domain;Ribonuclease B OB domain	cold shock protein	PF00313.23;PF08206.12
1713	0.12902561169824736	0.05532370161092599	-0.2150109783521072	0.03529167448788499	0.14766229833254868	0.020458803965039418	0.12019380784883764	0.14182941629821402	0.05835999444193278	Energy production and conversion	Amino acid racemase YgeA (RacX) (PDB:5ELL)	Asp/Glu/Hydantoin racemase	aspartate racemase [EC:5.1.1.13]	PF01177.23
1714	0.14350066077543014	-0.004040673425289811	-0.2544794663864358	-0.10531434009357807	0.11080145375305823	-0.18660849300906812	-0.005059875050549728	0.19905676787973345	0.07512532140163901	NA	NA	NA	NA	NA
1716	0.3065555081040029	0.08229211721249646	-0.0916453299832204	-0.28564206831417394	0.3553209720323157	0.056128016922607306	-0.05236703495489206	0.0490808960392821	0.0757003062999729	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	NA	PF00892.21
1717	-0.5062140628988476	-0.041543227433328125	0.1749265152090878	0.18831560354155835	-0.4306345635773709	-0.09541404319104621	-0.014620412554877196	0.04163774622194772	0.20478944497095036	NA	NA	Sarcosine oxidase, gamma subunit family	NA	PF04268.13
1718	0.4986182868833011	0.06606597559085604	-0.3885516296092577	-0.2857149314396614	0.38212319086495933	0.10710289590760085	0.09873955328300825	0.09485112610596462	0.044878588030883994	RNA processing and modification	Glycine cleavage system protein T (aminomethyltransferase) (GcvT) (PDB:2GAH) (PUBMED:25433025;25505271)!!!NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase (FadH2) (PDB:1VRQ)	FAD binding domain;FAD dependent oxidoreductase;2Fe-2S iron-sulfur cluster binding domain;Aminomethyltransferase folate-binding domain;Glycine cleavage T-protein C-terminal barrel domain;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Sarcosine oxidase A3 domain	methylglutamate dehydrogenase subunit C [EC:1.5.99.5]	PF00890.25;PF12831.8;PF13510.7;PF01571.22;PF08669.12;PF13450.7;PF07992.15;PF17806.2
1719	0.28636031764567854	0.053627306870059684	-0.46162308655739837	-0.10935155359247446	0.1904509422260969	-0.07974898640044775	0.09046059513604994	0.24943946791412747	0.025187622891025538	RNA processing and modification	Sarcosine oxidase delta subunit (SoxD) (PDB:2GAH)	Sarcosine oxidase, delta subunit family	sarcosine oxidase, subunit delta [EC:1.5.3.1]	PF04267.13
1720	0.07613998406123439	0.02655280797804156	-0.45047601543248683	0.08894704808902171	-0.12488787493588561	-0.18123327354372704	-0.050989372083548416	0.28533679853160043	0.021787643783633077	RNA processing and modification	Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;NAD(P)-binding Rossmann-like domain;Thi4 family;Tryptophan halogenase	methylglutamate dehydrogenase subunit A [EC:1.5.99.5];sarcosine oxidase, subunit beta [EC:1.5.3.1]	PF01266.25;PF13450.7;PF01946.18;PF04820.15
1723	-0.22559129936033673	0.10284962450965117	-0.1636391709076994	-0.035902463412266064	-0.18766657069603224	-0.037646693088067035	0.09292783506665991	0.234745017339035	0.08318095041895143	Amino Acid metabolis and transport	Alcohol dehydrogenase, class IV (EutG) (PDB:6AHC)	Iron-containing alcohol dehydrogenase;Iron-containing alcohol dehydrogenase	NA	PF00465.20;PF13685.7
1724	0.16462883849253007	0.04410805944806185	-0.19475220309263214	-0.16123464773419968	0.19565184796254212	0.0770552105786183	0.04375264108758341	0.15303608792620801	0.03608754135719008	Lipid metabolism	Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD (CzcO) (PDB:4USQ)	Flavin-binding monooxygenase-like;L-lysine 6-monooxygenase (NADPH-requiring);FAD-NAD(P)-binding;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase	trimethylamine monooxygenase [EC:1.14.13.148]	PF00743.20;PF13434.7;PF13454.7;PF07992.15;PF13738.7
1726	0.19076439799681252	-0.10301749090880388	0.01602021361666088	-0.10174606131793025	0.15126108526399504	0.19980001776368367	0.07293689063976819	-0.1239475535255793	0.06805201532780479	Amino Acid metabolis and transport	Glycerol kinase (GlpK) (PDB:2ZF5)	FGGY family of carbohydrate kinases, C-terminal domain;FGGY family of carbohydrate kinases, N-terminal domain	glycerol kinase [EC:2.7.1.30]	PF02782.17;PF00370.22
1727	0.2452960132942075	-2.9270249327458333e-4	-0.5715850453978811	0.1515342029368124	0.03001328020184334	-0.06249866725396845	0.24891192208238477	0.2239602601959579	0.024590649738373396	RNA processing and modification	ABC-type proline/glycine betaine transport system, permease component (ProW)	Binding-protein-dependent transport system inner membrane component	glycine betaine/proline transport system permease protein	PF00528.23
1728	-0.3811728534630461	-0.02066600322008252	-0.3824026540978189	0.2382687689856688	-0.4249145327333752	-0.24604792020282046	0.21414080418889886	0.24719829225589962	0.03296876810017315	RNA processing and modification	ABC-type proline/glycine betaine transport system, ATPase component (ProV)	AAA domain, putative AbiEii toxin, Type IV TA system;ABC transporter	glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9]	PF13304.7;PF00005.28
1729	0.352981098444456	0.16228133235970857	0.01122135252873448	0.10424549554416442	0.14389215881924272	0.14867949894556295	0.08392018500683739	-0.09776402179592966	0.05177989235224157	NA	NA	NA	NA	NA
1730	0.01790952802289627	0.21918549887813416	-0.02353660026182028	0.06952757688769745	0.053582936550935774	-0.004884615293445509	0.01761110634072752	0.0295727489091094	0.0903491315594446	NA	NA	MORN repeat	NA	PF02493.21
1735	0.4178335118418699	0.11325901752354024	-0.5402772186378693	-0.08830686545196727	0.2320998977063398	0.007291576307665969	0.08495777864597535	0.2482863539725598	0.025736056707084037	RNA processing and modification	Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;FAD-NAD(P)-binding;Pyridine nucleotide-disulphide oxidoreductase	NA	PF01266.25;PF13454.7;PF07992.15
1736	0.6128847323864031	0.02907723368378901	-0.4830141111190389	-0.05305431185199523	0.37061940086244033	0.10266296314019908	0.12943024776432446	0.019321368534425128	0.02226290645741835	RNA processing and modification	Glutamine synthetase (GlnA) (PDB:1F1H)	Glutamine synthetase, catalytic domain	glutamine synthetase [EC:6.3.1.2]	PF00120.25
1738	0.15169617116604514	0.14514731820745327	-0.28912244334114895	-0.057471167974987934	0.1152476793692959	-0.0038061619003889667	0.06742969994655416	0.17129251623590835	0.014351576255214427	RNA processing and modification	Glutamate synthase domain 3 (GltB3) (PDB:1EA0)	GXGXG motif	methylamine---glutamate N-methyltransferase subunit B [EC:2.1.1.21]	PF01493.20
1739	-0.3296295278386605	0.09866760553307205	0.1342028806164588	0.22272710361392972	-0.28879754688082093	-0.0160795967378075	0.11694532730174448	0.01866921507794348	0.01051844492476345	RNA processing and modification	Glutamate synthase domain 2 (GltB2) (PDB:1EA0)	FMN-dependent dehydrogenase;Conserved region in glutamate synthase;IMP dehydrogenase / GMP reductase domain	methylamine---glutamate N-methyltransferase subunit C [EC:2.1.1.21]	PF01070.19;PF01645.18;PF00478.26
1740	-0.3349995003259851	0.08990979720888408	-0.1631502282931417	0.23479883236452792	-0.3980917714837381	-0.0445896132347014	0.09887214304516219	0.19898893608081014	0.023972804314013	NA	NA	NA	NA	NA
1746	-0.14028530063339922	-0.07783234349662888	0.17366390833834952	0.05411248402517324	-0.187119572294189	0.06735204508823384	0.0812469065453291	-0.15125257455252966	0.07502862166834233	General Functional Prediction only	Deoxyribodipyrimidine photolyase (PhrB) (PDB:1TEZ)	DNA photolyase;FAD binding domain of DNA photolyase	deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]	PF00875.19;PF03441.15
1747	0.4879383530883447	-0.050597726112639393	-0.5493678448610756	-0.024131220215251013	0.2921340778534284	0.011862354378313745	0.2821878726300858	0.08394593397358437	0.0918516690378715	Energy production and conversion	Thiamin phosphate synthase YjbQ, UPF0047 family (YjbQ) (PDB:1VE0)	Uncharacterised protein family UPF0047	NA	PF01894.18
1748	0.4191868570479297	-0.030239394931019795	-0.42542908664782536	-0.03230415542971406	0.1782816875192851	0.1709263904024635	0.08048616716548809	0.06233461407779611	0.1474526823642083	Energy production and conversion	Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily (ZapE)	AFG1-like ATPase	cell division protein ZapE	PF03969.17
1749	0.3053546357454618	-0.11958283578638196	-0.3720818925157443	-0.09150699367760855	0.2549847822261767	0.06431671024324574	-0.015522977089286264	0.08729603433686674	0.044623668308988694	NA	NA	NA	NA	NA
1752	0.25331692324781674	-0.008863367337171657	-0.22296328233799934	0.27347033512957875	-0.03317669932098952	0.12100991890183992	0.11468770818474124	-0.049083031851569495	0.042253059492947345	Amino Acid metabolis and transport	Aconitase A (AcnA) (PDB:1ACO)	Aconitase family (aconitate hydratase);Aconitase C-terminal domain	aconitate hydratase [EC:4.2.1.3]	PF00330.21;PF00694.20
1756	-0.4980138774206366	-0.02310455727662113	0.3136325053201869	-0.04057852739288588	-0.4163194408808042	0.011921400932140192	-0.05700008416258642	-0.05947793889912689	0.05355867509051606	Replication and repair	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase (AdhE) (PDB:1A4S)	Aldehyde dehydrogenase family	NA	PF00171.23
1757	0.03363957811924139	-0.020612511968381306	-0.05682432491989452	-0.13004780988571746	0.054838333103196774	-0.02673529270683519	-0.029747040613371235	0.09527525051138169	0.018397003413315297	RNA processing and modification	Arginase/agmatinase family enzyme (SpeB) (PDB:1CEV)	Arginase family	agmatinase [EC:3.5.3.11]	PF00491.22
1766	-0.05214151257454455	0.23008548241461282	0.11525634250294924	0.03525919478973019	-0.004428807469162734	0.12819781517530673	0.05996713766967612	-0.013570976994053362	0.03821713343672373	RNA processing and modification	Xaa-Pro aminopeptidase (PepP) (PDB:1A16)	Creatinase/Prolidase N-terminal domain;Metallopeptidase family M24	ectoine hydrolase [EC:3.5.4.44]	PF01321.19;PF00557.25
1767	0.46838576060786247	0.2569765797293488	-0.25339054822713986	-0.0849387788044384	0.30273638367451405	0.06548787348504619	0.08521085437271889	0.09259450347139384	0.04371228263591119	Function Unknown	Maleate cis-trans isomerase (PDB:2DGD)	Arylmalonate decarboxylase	maleate isomerase [EC:5.2.1.1]	PF17645.2
1768	0.26865651617540864	-0.04950464482984239	0.11022488742120079	-0.21977151373257817	0.3320217083375942	0.030009003134189274	0.026417702713834056	-0.14552088405455832	0.046712553028552456	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family;Solute carrier family 35	O-acetylserine/cysteine efflux transporter	PF00892.21;PF06027.13
1769	0.21291831607247158	-0.11216006136422933	-0.3189345709531731	-0.01710466699861401	0.06949082536118102	-0.11966483768051923	0.07715905868445107	0.1288811628410699	0.06649290205386223	Replication and repair	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase (MmsB) (PDB:1I36)	NADP oxidoreductase coenzyme F420-dependent;NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase;NAD binding domain of 6-phosphogluconate dehydrogenase	3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]	PF03807.18;PF14833.7;PF03446.16
1770	0.0784855081223974	0.3814404745799301	-0.10103699155162783	0.04549487409558044	0.055516976455568315	-0.05008168262947809	-0.004263552128533161	0.17150431680831443	0.0428061329880397	Replication and repair	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase (AdhE) (PDB:1A4S)	Aldehyde dehydrogenase family	NA	PF00171.23
1778	-0.19678732711359978	0.14715736729878606	0.4390671451854638	0.1118151722648608	-0.1021719022638137	-0.044894848837735715	-0.08771106565364627	-0.14720067455012645	0.04281520134680488	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF849 family (PDB:3C6C)	beta-keto acid cleavage enzyme	3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]	PF05853.13
1787	0.06713722305514154	0.10909462049724845	-0.5306994971168532	0.08090805766077337	-0.005484097940883205	-0.1618779917315892	0.15002264092540954	0.3075029978425835	0.031287817240893676	NA	NA	Amino acid synthesis	NA	PF06684.12
1790	0.3612774339838123	-0.1553142026042353	-0.4708763024657349	0.15258975654867754	0.1360676123931501	-0.08271117792454741	0.4522190608460383	-0.035469829115215484	0.04889955063939232	RNA processing and modification	ABC-type branched-chain amino acid transport system, periplasmic component (LivK) (PDB:1USG)	Receptor family ligand binding region;Periplasmic binding protein	branched-chain amino acid transport system substrate-binding protein	PF01094.29;PF13458.7
1791	0.28989464879358867	0.07150433223084163	-0.12107017308306804	-0.21412017624142193	0.23854261302042729	0.21762445804970793	0.042995651979967825	-0.024908889821082535	0.07792058912882509	Energy production and conversion	Predicted arabinose efflux permease AraJ, MFS family (AraJ) (PDB:4LDS)	Major Facilitator Superfamily	NA	PF07690.17
1792	-0.03909796440892722	-0.03466907914772544	-0.38344474407520457	0.2880820432771018	-0.08897910113927375	-0.12330570227353846	0.11415513762079119	0.20567639566970414	0.020180942157742333	RNA processing and modification	ABC-type branched-chain amino acid transport system, permease component (LivM)	Branched-chain amino acid transport system / permease component	branched-chain amino acid transport system permease protein	PF02653.17
1793	0.15056526141503546	0.14862200155548308	-0.35687995368401587	0.014043930734952645	0.09873443555251356	-0.07646809171272907	-0.005824043934719681	0.24314225564535666	0.0214609698866649	RNA processing and modification	Branched-chain amino acid ABC-type transport system, permease component (LivH)	Branched-chain amino acid transport system / permease component	branched-chain amino acid transport system permease protein	PF02653.17
1794	0.14732059254151367	-0.15614254253408205	-0.15385111637514118	-0.10486138019813354	0.22101432035812302	0.06734342771874893	-0.0028176442820758494	0.043573215862682264	0.029205498156178573	RNA processing and modification	ABC-type branched-chain amino acid transport system, ATPase component LivF (LivF) (PDB:1JI0) (PUBMED:26527648;32250026)	AAA domain, putative AbiEii toxin, Type IV TA system;ABC transporter	branched-chain amino acid transport system ATP-binding protein;nonpolar-amino-acid-transporting ATPase [EC:7.4.2.2]	PF13304.7;PF00005.28
1795	-0.13441046137640064	-0.09915103988500786	-0.007468470208128816	0.25832441094046943	-0.19654479045668183	-0.023883069706958273	0.10845530286238397	-0.08852948042878434	0.022233236301936632	RNA processing and modification	ABC-type branched-chain amino acid transport system, ATPase component LivG (LivG) (PDB:1G9X) (PUBMED:29514851)	AAA domain, putative AbiEii toxin, Type IV TA system;ABC transporter;Branched-chain amino acid ATP-binding cassette transporter	branched-chain amino acid transport system ATP-binding protein;nonpolar-amino-acid-transporting ATPase [EC:7.4.2.2]	PF13304.7;PF00005.28;PF12399.9
1801	0.12525871166552888	0.1735593876019828	-0.22806008584314993	0.06095537278346441	-0.007331802382158341	-0.04840299313218503	0.24626288303724708	0.09361699489949402	0.03675776763291465	RNA processing and modification	ABC-type branched-chain amino acid transport system, ATPase component LivF (LivF) (PDB:1JI0) (PUBMED:26527648;32250026)	AAA domain, putative AbiEii toxin, Type IV TA system;ABC transporter	nonpolar-amino-acid-transporting ATPase [EC:7.4.2.2]	PF13304.7;PF00005.28
1805	0.19790086149218417	-0.10437531858466446	0.19831720078455503	-0.1701137263695646	0.1745754565288716	0.11921188335714017	0.11184612259237728	-0.23736133763846384	0.018663358248082133	RNA processing and modification	Branched-chain amino acid ABC-type transport system, permease component (LivH)	Branched-chain amino acid transport system / permease component	branched-chain amino acid transport system permease protein	PF02653.17
1806	-0.01697698001457727	-0.13328658460487613	0.26628552727162	-0.0038557136264908537	-0.03932248262626194	0.09921182530036994	-0.09262749172225153	-0.2056671892448877	0.10309109484088506	RNA processing and modification	ABC-type branched-chain amino acid transport system, periplasmic component (LivK) (PDB:1USG)	NA	NA	NA
1807	0.09765739189563763	0.053985470630262065	0.17391819491848817	-0.18774233430247353	0.07623508180289343	0.13432640457715678	-0.012061705048798855	-0.12732396862084033	0.05482684907018199	RNA processing and modification	Threonine/homoserine/homoserine lactone efflux protein (RhtB)	LysE type translocator	homoserine/homoserine lactone efflux protein	PF01810.19
1808	0.06775062702712385	-0.025877397730435202	-0.5793356409182726	0.27537873469274554	-0.10310379189601568	-0.15979558646905734	0.14146019128376305	0.2528719193250882	0.04198102436185247	NA	NA	Protein of unknown function (DUF2805)	NA	PF10985.9
1809	0.09893906641706712	0.05192633777781879	-0.3403453928818069	0.19845598290392386	0.038319291084189924	-0.1914091974530492	0.06974511688665262	0.2655503234274619	0.048127360114736374	Inorganic ion transport and metabolism	Glutaredoxin (GrxC) (PDB:1AAZ)	Glutaredoxin-like domain (DUF836);Glutaredoxin;SH3-binding, glutamic acid-rich protein	NA	PF05768.15;PF00462.25;PF04908.16
1811	-0.3484906962922729	-0.06852153519291475	-0.1658956220973823	0.08574054642488574	-0.34113710944046116	-0.24564181749033895	-0.04888125943753769	0.24421875423378595	0.05700122850574409	Inorganic ion transport and metabolism	Peptide methionine sulfoxide reductase MsrB (MsrB) (PDB:1L1D)	SelR domain	peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]	PF01641.19
1812	0.03754010159754681	-0.11976811539715297	-0.24879542655700815	0.41208228662155477	-0.05450892164904114	-0.31862025568077007	0.026409130637419537	0.12848542421077436	0.04642472991713813	Function Unknown	Acetoin utilization deacetylase AcuC or a related deacetylase (AcuC) (PDB:1C3P)	Histone deacetylase domain	histone deacetylase 11 [EC:3.5.1.98]	PF00850.20
1813	0.29486312955825944	0.06763935172905729	-0.26544064844647874	-0.2508134385949977	0.2696596137505567	0.07155475108831809	0.08695384844516268	0.08810265724505344	0.03736196465090015	Energy production and conversion	Phosphoglycerate dehydrogenase or related dehydrogenase (SerA) (PDB:3OET)	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain;D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	PF00389.31;PF02826.20
1814	0.28938377444576463	0.016841893659841924	-0.3140803215866702	-0.13002961470336918	0.3245589764085313	-0.03599257244166218	-0.05028574858453429	0.18880983438108495	0.04250016887858238	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	NA	PF00892.21
1815	0.13005421008880377	0.05680765404296023	-0.4114916724282823	-0.17147091223722472	0.16062212331656361	-0.054530363693064986	0.03707732741061167	0.2826425775835374	0.05002168782625801	RNA processing and modification	Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;NAD(P)-binding Rossmann-like domain	D-amino-acid dehydrogenase [EC:1.4.5.1];D-hydroxyproline dehydrogenase [EC:1.5.99.-]	PF01266.25;PF13450.7
1816	-0.1902868249773368	0.0601544150111304	-0.19691104564385892	0.1169788962028558	-0.0779788770711728	-0.07007776646295827	-0.04636169126275579	0.2526407947999222	0.05086579288186266	Energy production and conversion	Peptodoglycan polymerase FtsW/RodA/SpoVE (FtsW) (PDB:6BAR) (PUBMED:30692671)	Cell cycle protein	rod shape determining protein RodA	PF01098.20
1817	0.16013656460291928	-0.1045316224853114	-0.02191991486908985	-0.18985189729118074	-0.014706501580493652	0.11372887645901596	0.02063437952377322	-0.11106572217788208	0.05458444479387661	Energy production and conversion	Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) (FtsI) (PDB:6HZQ)	Penicillin-binding Protein dimerisation domain;Penicillin binding protein transpeptidase domain	penicillin-binding protein 2 [EC:3.4.16.4]	PF03717.16;PF00905.23
1818	0.07400830977039648	0.18599473008713732	0.05928487861608333	0.09266941293956801	0.05663635127620469	-0.016414532546827013	-0.17419153901880438	0.10010391244374538	0.07970164860239902	NA	NA	rod shape-determining protein MreD	rod shape-determining protein MreD	PF04093.13
1819	-0.09672907192878918	-0.051813173409245815	0.044566740296848185	0.10229585014184171	-0.029890371398961404	-0.08999590507140864	-0.0978703911543323	-0.021776293748382084	0.15133959563540775	Energy production and conversion	Cell shape-determining protein MreC (MreC) (PDB:2J5U)	rod shape-determining protein MreC	rod shape-determining protein MreC	PF04085.15
1820	-0.13592178927411036	-0.049503506916732797	-0.3615609292590193	0.14875426064478867	-0.2215778607769699	-0.032156856620646435	0.01661999756348614	0.1962771363596617	0.020424203837156266	Energy production and conversion	Cell shape-determining ATPase MreB, actin-like superfamily (MreB) (PDB:1JCE)	Actin;Cell division protein FtsA;Hsp70 protein;MreB/Mbl protein;Type IV pilus assembly protein PilM;	rod shape-determining protein MreB and related proteins	PF00022.20;PF14450.7;PF00012.21;PF06723.14;PF11104.9
1822	-0.1193048224779302	0.0496622682954071	0.3423888180996874	-0.08397601555143605	0.018760993444785393	0.0348625125528057	-0.06231084848534158	-0.039619981430934405	0.0542370041554359	Inorganic ion transport and metabolism	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain (GsiA)	ATPase family associated with various cellular activities (AAA);AAA domain, putative AbiEii toxin, Type IV TA system;AAA domain;P-loop containing region of AAA domain;ABC transporter;NB-ARC domain;Oligopeptide/dipeptide transporter, C-terminal region;Phosphoribulokinase / Uridine kinase family;RNA helicase;RecF/RecN/SMC N terminal domain;Bacterial TniB protein	peptide/nickel transport system ATP-binding protein;peptide/nickel transport system ATP-binding protein	PF00004.30;PF13304.7;PF13401.7;PF13555.7;PF00005.28;PF00931.23;PF08352.13;PF00485.19;PF00910.23;PF02463.20;PF05621.12
1823	0.11064420815057482	0.0207864544041379	-0.03557062853179948	0.048992420360501804	0.11681308176873198	-0.11038642102451884	-7.668692158742256e-4	0.044952389515438604	0.023062686458906866	RNA processing and modification	ABC-type dipeptide/oligopeptide/nickel transport system, permease component (DppC)	Binding-protein-dependent transport system inner membrane component;N-terminal TM domain of oligopeptide transport permease C	peptide/nickel transport system permease protein	PF00528.23;PF12911.8
1824	0.27278706688823956	0.07708008006611555	-0.13639317541488127	0.0097030618125502	0.20852880926361556	0.01810837146168609	0.1264320817902479	-9.657515070534181e-4	0.023446144336313677	RNA processing and modification	ABC-type dipeptide/oligopeptide/nickel transport system, permease component (DppB)	Binding-protein-dependent transport system inner membrane component	peptide/nickel transport system permease protein	PF00528.23
1825	0.3972239922551349	0.01095314075345495	-0.6572785233114188	0.02030748563523957	0.10882787264723484	-0.1300219719258515	0.16868749403559907	0.2533713388465706	0.03698376485907639	RNA processing and modification	ABC-type transport system, periplasmic component (DdpA) (PDB:3RQT)	Bacterial extracellular solute-binding proteins, family 5 Middle	peptide/nickel transport system substrate-binding protein	PF00496.23
1826	0.1102142414879495	0.09306999877371971	-0.4007858263436421	0.008316379315628352	0.05312451165099809	-0.1400674902316695	0.10636090016271584	0.27168099035835125	0.015916735549291117	RNA processing and modification	Ketol-acid reductoisomerase (IlvC) (PDB:1NP3)	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain;S-adenosyl-L-homocysteine hydrolase, NAD binding domain;NADP oxidoreductase coenzyme F420-dependent;Acetohydroxy acid isomeroreductase, catalytic domain;Acetohydroxy acid isomeroreductase, NADPH-binding domain	ketol-acid reductoisomerase [EC:1.1.1.86]	PF02826.20;PF00670.22;PF03807.18;PF01450.20;PF07991.13
1827	0.2762174568622047	0.010027839816804725	-0.021369305951431158	-0.1707579314904789	0.31003924764781676	-0.010124195675790603	-0.06037212335957375	-0.0025399091132585904	0.048812647326290023	RNA processing and modification	Acetolactate synthase, small subunit (IlvH) (PDB:2F1F)	ACT domain;ACT domain;Small subunit of acetolactate synthase	acetolactate synthase I/III small subunit [EC:2.2.1.6]	PF01842.26;PF13710.7;PF10369.10
1828	0.2455338387907605	0.09805422174203625	-0.42189428509095955	-0.025177550655138617	0.1540550713273422	-0.02717546148364673	0.032417247610288434	0.26112662514384155	0.0350099561045792	RNA processing and modification	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme (IlvB) (PDB:1BFD)	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;Thiamine pyrophosphate enzyme, central domain;Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	PF02775.22;PF00205.23;PF02776.19
1829	0.10638701189495052	-0.07810134654220478	-0.21942490373054552	-0.07250676458396786	0.060118788054157705	-0.01751610105246707	0.1253133699621314	0.06589394129535611	0.11986396698336202	Signal Transduction	tRNA A37 N6-isopentenylltransferase MiaA (MiaA) (PDB:2ZM5)	IPP transferase;Isopentenyl transferase	tRNA dimethylallyltransferase [EC:2.5.1.75]	PF01715.18;PF01745.17
1830	-0.04173456009938048	-0.24746279442458802	-0.1250671377714864	0.05844613950840959	8.304289061549532e-4	-0.09084636478186241	0.02486996871843382	0.036648707445826725	0.053845437905565	Inorganic ion transport and metabolism	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain (DegQ) (PDB:2HGA) (PUBMED:29686141)	GRASP55/65 PDZ-like domain;PDZ domain;PDZ domain;PDZ domain;Trypsin;Trypsin-like peptidase domain	serine protease Do [EC:3.4.21.107]	PF04495.15;PF00595.25;PF13180.7;PF17820.2;PF00089.27;PF13365.7
1831	-0.3518047332436972	-0.19704268227424504	0.06162407682785914	0.1924705466925071	-0.278385829828645	-0.07371062733030835	-0.06568981170941206	0.07431298163509492	0.10488449599615403	Nucleotide metabolism and transport	Uncharacterized conserved protein YjeT, DUF2065 family (yjeT)	Uncharacterized protein conserved in bacteria (DUF2065)	uncharacterized protein	PF09838.10
1832	0.041832003783272294	0.040101709113432804	-0.6103931564889954	0.08585805981452337	-0.096141241905685	-0.2667034784848868	0.09554077449590725	0.4065800781709486	0.02139536955593261	Inorganic ion transport and metabolism	Regulator of protease activity HflC, stomatin/prohibitin superfamily (HflC)	SPFH domain / Band 7 family	modulator of FtsH protease HflC	PF01145.26
1833	0.041909312862690694	0.08486428813949622	-0.48078915088040397	0.1328611222021267	-0.029069175382164962	-0.11819203145884509	0.17441759731467227	0.27908109914813	0.017952182626010685	Inorganic ion transport and metabolism	Regulator of protease activity HflC, stomatin/prohibitin superfamily (HflC)	SPFH domain / Band 7 family;Bacterial membrane protein N terminal	modulator of FtsH protease HflK	PF01145.26;PF12221.9
1834	0.10500158767304306	0.07399250096315577	0.1386100352931198	-0.05545068989114612	0.20473822512954568	-0.06245603367157686	-0.06839186641247821	-0.0036620555892606125	0.057302945981396736	Energy production and conversion	Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family (Mrp) (PDB:2PH1) (PUBMED:18616280;19114487;31709520)	AAA domain;CobQ/CobB/MinD/ParA nucleotide binding domain;4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family;ATPase MipZ;NUBPL iron-transfer P-loop NTPase	ATP-binding protein involved in chromosome partitioning	PF13614.7;PF01656.24;PF00142.19;PF09140.12;PF10609.10
1835	-0.034444262366334855	0.10756036384734584	-0.1802832388072169	0.0491010227360878	-0.029410370541096218	-0.11456897508012026	0.08963471655510054	0.17837221705496842	0.041815027173870235	Cell motility	Thymidylate synthase ThyX, FAD-dependent family (ThyX) (PDB:1KQ4)	Thymidylate synthase complementing protein	thymidylate synthase (FAD) [EC:2.1.1.148]	PF02511.16
1851	0.036652180474630036	0.06225321146882089	-0.04523214244276867	-0.037524925784334286	0.03942725554585793	-0.003585465440613356	0.034832796874493956	0.07806023356848366	0.05260852204150961	Energy production and conversion	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase (PpsA) (PDB:5HV6)	PEP-utilising enzyme, mobile domain;PEP-utilising enzyme, PEP-binding domain;Pyruvate phosphate dikinase, AMP/ATP-binding domain	pyruvate, orthophosphate dikinase [EC:2.7.9.1]	PF00391.24;PF02896.19;PF01326.20
1852	0.004593470534354815	0.05598922579217739	-0.3249294410095916	0.03360149263960634	-0.09143729596677307	-0.13195123481600948	0.09773215627885144	0.25493160126080505	0.08351957981778173	Signal Transduction	Glycyl-tRNA synthetase, beta subunit (GlyS)	DALR anticodon binding domain;Glycyl-tRNA synthetase beta subunit	glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	PF05746.16;PF02092.18
1853	0.32841912897924913	0.08454059796805376	-0.39953731991082625	-0.07132901678316703	0.23269642375243518	-0.0280699771534286	0.15656717393982741	0.16518084808432934	0.05059536879856144	Signal Transduction	Glycyl-tRNA synthetase, alpha subunit (GlyQ) (PDB:1J5W)	Glycyl-tRNA synthetase alpha subunit	glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	PF02091.16
1854	-0.22034411403620965	0.07794685838729637	-0.4397417636898207	0.33248098106133905	-0.23704340308647484	-0.2388966053601906	-0.0034630256375336346	0.3003956047433912	0.04658986421831213	Inorganic ion transport and metabolism	Periplasmic serine protease, ClpP class (SppA) (PDB:3BEZ)	Clp protease;Peptidase family S49;Serine dehydrogenase proteinase	protease IV [EC:3.4.21.-]	PF00574.24;PF01343.19;PF01972.17
1855	0.3615095360457616	0.037869793897643424	-0.6092891961623934	-0.05752342242443611	0.06280747755340584	0.014536039377252914	0.26539947887563764	0.1838794055963547	0.06234893760132938	Energy production and conversion	Geranylgeranyl pyrophosphate synthase (IspA) (PDB:2AZJ)	Polyprenyl synthetase	octaprenyl-diphosphate synthase [EC:2.5.1.90]	PF00348.18
1856	-0.07872301458454063	-0.03198430616318478	-0.1306655992030468	-0.05526452651589754	-0.09817996474135086	-0.07560566203371649	-0.03090543404439703	0.15539446086100564	0.10851404741065698	Energy production and conversion	Pyridoxine/pyridoxamine 5'-phosphate oxidase (PdxH) (PDB:1CI0)	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region;Pyridoxamine 5'-phosphate oxidase;Pyridoxamine 5'-phosphate oxidase	pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]	PF10590.10;PF01243.21;PF12766.8
1857	0.33015984475818394	0.0665457068904107	-0.39735416572301174	-0.051994875381588895	0.18966447658577665	-0.009936182725091076	0.14665137710321435	0.11160603274865255	0.04314768406619263	RNA processing and modification	Chorismate synthase (AroC) (PDB:1Q1L)	Chorismate synthase	chorismate synthase [EC:4.2.3.5]	PF01264.22
1858	-0.34877765157227464	-0.11731331222027681	0.08992813858652589	0.11059623020103886	-0.15389103916507738	-0.08670846870210519	-0.0769892770275861	0.03654080677250692	0.048845508052508736	Energy production and conversion	Deoxyxylulose-5-phosphate synthase (Dxs) (PDB:2O1S)	1-deoxy-D-xylulose-5-phosphate synthase;Dehydrogenase E1 component;Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;Transketolase, C-terminal domain;Transketolase, thiamine diphosphate binding domain;Transketolase, pyrimidine binding domain	1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	PF13292.7;PF00676.21;PF02775.22;PF02780.21;PF00456.22;PF02779.25
1859	0.34178420707746754	0.06949862979365748	-0.4095713020861746	-0.046498734790223976	0.23343339822323833	0.017206481199165825	0.18838189360062735	0.12504175777624388	0.07096617519215401	Energy production and conversion	Geranylgeranyl pyrophosphate synthase (IspA) (PDB:2AZJ)	Polyprenyl synthetase	NA	PF00348.18
1860	0.22379023357289754	0.1517414047949464	-0.3423863739109939	-0.12522970561588295	0.1084654471447066	-0.03038425219289485	0.05878850008478887	0.25630142343175294	0.11201523905101819	NA	NA	NA	NA	NA
1861	0.25172436319534097	0.10882526775411293	-0.46232681098980866	0.00567533851500493	0.09029433435527472	-0.015098698797718727	0.14418774922696537	0.2053399940102834	0.08219789157242569	Signal Transduction	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC (TsaC) (PDB:1HRU)	Putative GTP-binding controlling metal-binding;Telomere recombination	L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	PF03481.14;PF01300.19
1862	0.3040884058739267	0.10974480069214781	-0.2775476822176318	-0.06801293869290895	0.21408603911126278	0.10418216606600134	-0.011294221224395013	0.1288845653860367	0.06064268188081342	Cell cycle control and mitosis	ABC-type multidrug transport system, ATPase component (CcmA) (PDB:5DO7)	ATPase family associated with various cellular activities (AAA);AAA domain, putative AbiEii toxin, Type IV TA system;ABC transporter	NA	PF00004.30;PF13304.7;PF00005.28
1863	0.029643392631641757	0.0944536946238165	0.6177730156452662	-0.14554312304276676	0.3023238251700953	0.211030035506331	-0.2066704539667584	-0.25137141207000674	0.04306934233413874	Cell cycle control and mitosis	ABC-type multidrug transport system, permease component (YadH)	NA	poly(3-hydroxybutyrate) depolymerase [EC:3.1.1.75]	NA
1864	-0.3764495844385381	0.07921074785587355	-0.4427492199670461	0.33419928784276637	-0.5081373631700229	-0.3559939195290726	0.0931975856573871	0.36643417023475244	0.09545560804873887	Signal Transduction	Pseudouridine synthase RluA, 23S rRNA- or tRNA-specific (RluA) (PDB:2I82)	RNA pseudouridylate synthase;S4 domain	23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	PF00849.23;PF01479.26
1865	-0.19635336632396644	-0.0461594260313124	-0.2640984086973155	0.17181115626980709	-0.11542168421845732	-0.08285818121607808	-0.0352699240398847	0.21727765674056596	0.024114155411011733	Signal Transduction	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) (RpoD) (PDB:1SIG)	Sigma-70 factor, region 1.2;Sigma-70 region 2;Sigma-70, region 4	RNA polymerase sigma-32 factor	PF00140.21;PF04542.15;PF04545.17
1866	-0.3214050044614971	-0.04092075470617194	0.0030022001302310295	0.48342593316088256	-0.37650172221687295	-0.11546046509085206	0.14351970912785364	0.04975092857424762	0.04628453414208068	Cell motility	Adenylosuccinate synthase (PurA) (PDB:1ADE)	Adenylosuccinate synthetase	adenylosuccinate synthase [EC:6.3.4.4]	PF00709.22
1867	0.05493683115614228	0.083140199764018	-0.2715957087205042	0.13381751576541598	0.017392475280284377	-0.044448644271242704	0.2246575228991593	0.1296771500448044	0.10625596802316921	Energy production and conversion	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (ThiD) (PDB:1Y9X) (PUBMED:17351295)	pfkB family carbohydrate kinase;Phosphomethylpyrimidine kinase	hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	PF00294.25;PF08543.13
1868	0.09656583517436113	0.10258622513226807	0.05695692496536574	-0.027106944413032862	0.14789224208553742	0.10252813879250003	0.0718658242615107	0.001191546153469112	0.05784017354576049	Energy production and conversion	Phosphomannomutase (ManB) (PDB:6MNV)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I;Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II;Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III;Phosphoglucomutase/phosphomannomutase, C-terminal domain	phosphoglucosamine mutase [EC:5.4.2.10]	PF02878.17;PF02879.17;PF02880.17;PF00408.21
1869	-0.31687447129798124	-0.017793100343343988	0.20134406292309595	0.1209697475365817	-0.26429936745157107	-0.047163839378240105	0.020017425655564993	0.014382445698857547	0.14322397648064383	Energy production and conversion	Dihydropteroate synthase (FolP) (PDB:1AD1)	Pterin binding enzyme	dihydropteroate synthase [EC:2.5.1.15]	PF00809.23
1870	-0.4266295493247922	-6.90770505949967e-4	-0.17985511327413842	0.32720010690219115	-0.48213916552097624	-0.1734074742548532	0.1799458018389271	0.18000259538557456	0.018667709718872282	Inorganic ion transport and metabolism	ATP-dependent Zn proteases (HflB) (PDB:1LV7)	ATPase family associated with various cellular activities (AAA);AAA domain (dynein-related subfamily);AAA+ lid domain;FtsH Extracellular;Peptidase family M41;TIP49 P-loop domain	cell division protease FtsH [EC:3.4.24.-]	PF00004.30;PF07728.15;PF17862.2;PF06480.16;PF01434.19;PF06068.14
1871	0.10049384106554485	-0.002193555376286353	0.014131699777359666	-0.0902472827333012	0.1457702273413843	0.014931402525625413	-0.15161208204087118	-0.00892012546678267	0.1896709310650478	Signal Transduction	tRNA(Ile)-lysidine synthase TilS/MesJ (TilS) (PDB:1NI5) (PUBMED:21435031)	PP-loop family	tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	PF01171.21
1872	0.22123731971224758	-0.18065202209673897	0.1371757019341758	-0.1459138300885036	0.22087903333004907	0.2716630779291456	0.023370895793333766	-0.18342043322886098	0.0714871224543047	Energy production and conversion	Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction (CpoB) (PDB:2WZ7) (PUBMED:25951518)	Tetratricopeptide repeat	NA	PF13432.7
1873	0.030156979207327562	-0.08497516469802872	-0.3731940168723557	0.08104627536212207	0.03364446188915953	0.10407489879002992	-0.05803471684371253	0.20182091124769563	0.05408118771320028	Energy production and conversion	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins (OmpA) (PDB:1OAP)	OmpA family	peptidoglycan-associated lipoprotein	PF00691.21
1874	0.008679673339219133	0.1356948963113575	-0.4802529836010097	0.05022340381008676	-0.0011028440134333314	-0.18265259320434943	0.14026688653227712	0.3569148156998984	0.02564511574675554	Lipid metabolism	Periplasmic component TolB of the Tol biopolymer transport system (TolB) (PDB:1C5K)	Dipeptidyl peptidase IV (DPP IV) N-terminal region;WD40-like Beta Propeller Repeat;TolB amino-terminal domain	TolB protein	PF00930.22;PF07676.13;PF04052.14
1875	0.35938115433522266	0.09821735059670393	-0.31696443167822663	-0.03384679709522636	0.2495680195223077	-0.03324638090741538	0.21501836348821116	0.0383517750692927	0.03857463831716947	NA	NA	NA	NA	NA
1876	0.13329318312089725	-0.053312068084880246	-0.4811358924806087	0.16931210069571143	-0.022311848650893994	-0.20114797924849595	0.1281199925090776	0.23256716540014497	0.008163572264135149	Lipid metabolism	Biopolymer transport protein ExbD (ExbD) (PDB:2JWK)	Biopolymer transport protein ExbD/TolR	biopolymer transport protein TolR;biopolymer transport protein ExbD	PF02472.17
1877	0.14823393053036577	0.008251178819292576	-0.18500034516898797	-0.18353263639379255	0.0395256424099627	-0.053394805114382465	0.01006025307518072	0.06027603387235216	0.03274150029647636	Lipid metabolism	Biopolymer transport protein ExbB/TolQ (TolQ) (PDB:5SV0)	MotA/TolQ/ExbB proton channel family	biopolymer transport protein ExbB;biopolymer transport protein TolQ	PF01618.17
1878	0.3165180425359664	0.06189299129050317	-0.31993263199265193	-0.13842544106428514	0.2516397833146566	0.028837324684597616	0.14883635002450793	0.08274143938175675	0.037377985044815015	NA	NA	Lactococcus phage M3 protein	NA	PF07066.12
1879	-0.2820395174398201	-0.1555879546430901	0.5389282688773592	0.006389724267650191	-0.11467909465711698	0.005684616745474272	-0.22396409059534825	-0.198155693298636	0.07801687134738433	Signal Transduction	Transcriptional and/or translational regulatory protein YebC/TACO1 (TACO1) (PDB:1KON)	Transcriptional regulator	translational activator of cytochrome c oxidase 1	PF01709.21
1880	0.16124349689620557	0.07739126265640082	-0.24365958654236924	-0.011400937416484467	0.10551672702693604	-0.04168433125558036	0.013671347690384698	0.13681805108577766	0.06715951619528125	Function Unknown	2',3'- and 3',5'-cNMP phosphodiesterase YmdB, calcineurin family (YmdB) (PDB:2CV9) (PUBMED:24163345)	Calcineurin-like phosphoesterase;YmdB-like protein	uncharacterized protein	PF00149.29;PF13277.7
1881	-0.4833360306270491	-0.2543564558785178	-0.18873355802606268	0.2508846270826926	-0.55615940120753	-0.22601663091317803	0.0426570122936695	0.2179707605964179	0.2097759770556072	Energy production and conversion	5-formyltetrahydrofolate cyclo-ligase (FAU1) (PDB:1SBQ)	5-formyltetrahydrofolate cyclo-ligase family	5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	PF01812.21
1882	-0.05759405896590233	-0.059499753307643545	-0.33134148875704633	0.04756891285565949	-0.15624077224863162	-0.01879826852210866	-0.007059856830765174	0.2018077282025121	0.059701775940185844	Energy production and conversion	Cell division protein ZapA, inhibits GTPase activity of FtsZ (ZapA) (PDB:1T3U)	Cell division protein ZapA	cell division protein ZapA	PF05164.14
1883	0.29905365485497465	0.14859065319668163	-0.3964617321423767	-0.08263928098324953	0.20802879049676945	0.019801601407220096	-0.03261569474670704	0.2537192714851095	0.059106108756354706	NA	NA	NA	NA	NA
1884	-0.1843021021718422	0.02855973713528676	0.7043693553693289	-0.010099907248515807	0.06815236240373697	0.2204081164768551	-0.19593106995017548	-0.24745333283283993	0.08224475303225728	Energy production and conversion	Transketolase (TktA) (PDB:1AY0)	1-deoxy-D-xylulose-5-phosphate synthase;Dehydrogenase E1 component;Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;Transketolase, C-terminal domain;Transketolase, thiamine diphosphate binding domain;Transketolase, pyrimidine binding domain	transketolase [EC:2.2.1.1]	PF13292.7;PF00676.21;PF02775.22;PF02780.21;PF00456.22;PF02779.25
1885	-0.1571053028202047	0.07359870097663108	-0.12413244762600581	0.09245592822279741	-0.23830391321895175	-0.004739490470873129	0.10236162161654327	0.0894280353848122	0.09421375742375412	Energy production and conversion	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase (GapA) (PDB:3ZDF)	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain;Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	PF02800.21;PF00044.25
1886	-0.449200132808423	-0.12639558056407624	0.4992154626523404	0.24271386586081534	-0.23216447891654957	-0.049468582388065195	-0.03127648882601069	-0.13729189797155658	0.18887246615170514	Energy production and conversion	3-phosphoglycerate kinase (Pgk) (PDB:13PK)	Phosphoglycerate kinase	phosphoglycerate kinase [EC:2.7.2.3]	PF00162.20
1887	-0.2707258221331058	-0.1011266484624134	-0.004174615531943468	0.1901301692133873	-0.28884859637633564	0.08785645883996956	0.21294946126650827	-0.0899002357794926	0.10230780048311869	Energy production and conversion	Fructose-bisphosphate aldolase class 1 (Fba1)	Fructose-bisphosphate aldolase class-I	fructose-bisphosphate aldolase, class I [EC:4.1.2.13]	PF00274.20
1888	-0.03134630379104818	0.03629364822380356	-0.28195447419091235	-0.08165509521855371	0.01753302867492074	-0.07633023160512052	0.024381615909018366	0.20935613601281877	0.20979274134424303	Energy production and conversion	Thiamine monophosphate synthase (ThiE) (PDB:1G4T) (PUBMED:19060138)	Thiamine monophosphate synthase	thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	PF02581.18
1889	-0.30676195498067155	0.15185099556941123	0.39486516729033005	0.17472805092900268	-0.302564254496231	-0.05258227222979003	-0.05568989612971961	-0.07435940868460271	0.06474632118913243	Signal Transduction	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) (Efp) (PDB:1UEB)	Elongation factor P (EF-P) OB domain;Elongation factor P (EF-P) KOW-like domain;Elongation factor P, C-terminal	elongation factor P	PF01132.21;PF08207.13;PF09285.12
1890	-0.24656055656023806	-0.10895350739016539	0.00768183934913937	-0.040385051172385875	-0.11159142979528318	-0.04925369440646312	-0.19139957543601116	0.1924031736940287	0.06726098152628192	Energy production and conversion	Archaeal fructose-1,6-bisphosphatase or related enzyme, inositol monophosphatase family (SuhB) (PDB:1AWB)	Inositol monophosphatase family	myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]	PF00459.26
1891	-0.03314432618537085	-0.11727369089884455	-0.12903492621547405	0.18809693651115397	-0.2691072446105776	-0.1347548446151229	0.08029821794477565	0.014397387043172461	0.04453300668720669	Signal Transduction	Ribosomal protein L31 (RpmE) (PDB:1VS6)	Ribosomal protein L31	large subunit ribosomal protein L31	PF01197.19
1898	-0.07491667266661131	-0.17031681788848507	0.22596488980401086	0.010435764913968642	-0.07067890024926785	-0.06711899584277098	-0.13848932741880382	-0.14105654589868327	0.02583552632202661	Amino Acid metabolis and transport	NAD/NADP transhydrogenase alpha subunit (PntA) (PDB:1F8G)	4TM region of pyridine nucleotide transhydrogenase, mitoch	NA	PF12769.8
1922	0.24097759893456133	-0.04656045494574561	-0.14417359958344317	-0.08334230670042636	0.21824132574941982	0.07439443223598648	0.06181566280902747	0.003528073615643432	0.20853284287808	Signal Transduction	Methylase of polypeptide chain release factors (HemK) (PDB:1NV8)	Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methionine biosynthesis protein MetW;Methyltransferase small domain;N-6 DNA Methylase;Ribosomal protein L11 methyltransferase (PrmA);PrmC N-terminal domain;Putative RNA methylase family UPF0020	release factor glutamine methyltransferase [EC:2.1.1.297]	PF08241.13;PF13489.7;PF13649.7;PF13847.7;PF07021.13;PF05175.15;PF02384.17;PF06325.14;PF17827.2;PF01170.19
1923	-0.28261845555664034	-0.10155871315809574	0.13633693157839996	0.15259134855681064	-0.30143474502099277	0.0031488184010298923	-8.777101997538374e-5	-0.04234153802581851	0.04375314190268207	Signal Transduction	Protein chain release factor RF1 (PrfA) (PDB:1RQ0)	PCRF domain;RF-1 domain	peptide chain release factor 1	PF03462.19;PF00472.21
1925	0.05678739447666533	-0.18687865511332236	-0.16078896690483524	-0.0516859563112678	0.1302986871801389	-0.11407931972136756	0.039046247181879906	0.1219319176101105	0.06681719830228336	RNA processing and modification	Aspartate kinase (MetL1) (PDB:2CDQ)	Amino acid kinase family;ACT domain;ACT domain	aspartate kinase [EC:2.7.2.4]	PF00696.29;PF01842.26;PF13840.7
1926	0.02410111234291438	-0.20337455651290262	-0.2231267667853161	0.025699416182586744	0.13043748752239887	-0.1703906827261949	0.1009450603472156	0.04995022537640788	0.09291609217688236	Energy production and conversion	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase (UbiG) (PDB:1BHJ)	Mycolic acid cyclopropane synthetase;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;AdoMet dependent proline di-methyltransferase;Methyltransferase small domain;Nodulation protein S (NodS);Ribosomal protein L11 methyltransferase (PrmA);Tellurite resistance protein TehB;ubiE/COQ5 methyltransferase family	2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase [EC:2.1.1.222 2.1.1.64]	PF02353.21;PF08241.13;PF08242.13;PF13489.7;PF13649.7;PF13847.7;PF05891.13;PF05175.15;PF05401.12;PF06325.14;PF03848.15;PF01209.19
1927	0.2174399152534032	0.05361478379347833	-0.07794280351928864	-0.11535838593107782	0.2293422526758869	-0.010275040467893098	0.047023739388783105	0.04731495471054758	0.11155927194998357	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF1178 domain	Protein of unknown function (DUF1178)	NA	PF06676.12
1928	0.1355735873719532	0.07612031655619048	-0.20187462022783315	-0.1201223177980678	-0.0026985535622918127	-0.012202652221366276	0.045879080612722084	0.04099290642529494	0.07424523555705195	RNA processing and modification	Glutamate N-acetyltransferase (ornithine transacetylase) (ArgJ) (PDB:1VRA)	ArgJ family	glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]	PF01960.19
1929	0.09167549165442111	-0.1881157506338683	0.0797701930082079	-0.04270982931715664	0.08401753864093874	0.24311309483794544	-0.0560322563863697	-0.13518974483020543	0.06215101876009273	Lipid metabolism	Preprotein translocase subunit SecA (ATPase, RNA helicase) (SecA) (PDB:2FSF)	Helicase conserved C-terminal domain;SecA DEAD-like domain;SecA preprotein cross-linking domain;SecA Wing and Scaffold domain	preprotein translocase subunit SecA [EC:7.4.2.8]	PF00271.32;PF07517.15;PF01043.21;PF07516.14
1930	0.25030426463888467	0.025046312542382935	0.3310491191104907	0.0068889983183017	0.2033508930387191	0.2660137130114897	0.1095441914034194	-0.30202014798312893	0.060226828140539555	Replication and repair	Acetyl-CoA carboxylase alpha subunit (AccA) (PDB:2F9I)	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit;Carboxyl transferase domain	acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	PF03255.15;PF01039.23
1931	0.30953253981880746	0.043927444146843186	-0.1484278898301793	-0.23849894270892308	0.34931461460779734	0.10762475666581563	0.0329802495440648	0.01708977520302853	0.039350706638744126	Amino Acid metabolis and transport	Malate synthase (AceB) (PDB:1D8C)	Malate synthase	malate synthase [EC:2.3.3.9]	PF01274.23
1932	0.20621570110691165	0.1724373724316324	0.026043236925129828	-0.08061842406698543	0.23517018383262234	0.01227294127128357	-0.008247348190138662	-0.026447454380653435	0.021562193177301663	General Functional Prediction only	Recombinational DNA repair protein RecR (RecR) (PDB:2JGR) (PUBMED:26337406)	Toprim domain;Toprim domain	recombination protein RecR	PF01751.23;PF13662.7
1933	0.36145225136906134	-0.11746198110641601	0.07259748722871436	-0.2691725886507034	0.47815420795263885	0.10782288446637546	-0.006270527391823984	-0.07151215458072528	0.026273111585311752	Signal Transduction	DNA-binding nucleoid-associated protein YbaB/EfbC (YbaB) (PDB:1J8B) (PUBMED:19594923;22544270)	YbaB/EbfC DNA-binding family	uncharacterized protein	PF02575.17
1934	0.24637169897733913	-0.0387508774074277	0.19513459862354623	-0.19404846186226934	0.30111021154023376	0.14262763586013	-0.010723405267523757	-0.15705318496680704	0.08310244969667603	General Functional Prediction only	DNA polymerase III, gamma/tau subunits (DnaX) (PDB:1A5T)	ATPase family associated with various cellular activities (AAA);DNA polymerase III, delta subunit;DNA polymerase III subunits gamma and tau domain III;DNA polymerase III gamma and tau subunits C terminal;Holliday junction DNA helicase RuvB P-loop domain	DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	PF00004.30;PF13177.7;PF12169.9;PF12362.9;PF05496.13
1935	-0.048482013895071396	0.066809658824798	-0.20575690220635995	0.0846355083651211	-0.06673872399681216	-0.06641379039595781	0.09243256347131229	0.1815279106629133	0.04148353708764631	RNA processing and modification	Prephenate dehydratase (PheA2) (PDB:1PHZ)	Prephenate dehydratase	prephenate dehydratase [EC:4.2.1.51]	PF00800.19
1936	0.4759711966810318	-0.08028824302230808	0.03445704734651378	-0.13272439378572304	0.3481301473733956	0.2094267350302947	0.06449706733884787	-0.30945122489591925	0.11695350980195346	Energy production and conversion	CMP-2-keto-3-deoxyoctulosonic acid synthetase (KdsB) (PDB:1VH1)	Cytidylyltransferase;MobA-like NTP transferase domain	3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	PF02348.20;PF12804.8
1938	0.2060391084651655	-0.1584688525088415	0.30792982356629683	-0.2756710164894067	0.28807497836878404	0.3040652586824043	-0.2436446575831563	-0.30559369738950776	0.06464342949604832	RNA processing and modification	Ornithine carbamoyltransferase (ArgF) (PDB:1A1S)	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	ornithine carbamoyltransferase [EC:2.1.3.3]	PF00185.25;PF02729.22
1955	0.2918385543806108	-0.036367629715597094	-0.5019090456873256	-0.15118014711846367	0.24196294313629035	-0.03280623766561568	0.11194937846958952	0.22838064113968307	0.025376997771182908	Inorganic ion transport and metabolism	Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family (CnoX) (PDB:3QDN) (PUBMED:21498507;29754824)	Thioredoxin;Thioredoxin-like domain	thioredoxin 1	PF00085.21;PF13098.7
1956	0.08553241293573327	0.07620005873865297	-0.31812482017850013	-0.09118212817200887	0.10605684393248237	-0.11795581269964588	-0.013615089449295622	0.2577899567686069	0.019756717549093465	General Functional Prediction only	Exonuclease I (degrades ssDNA) (SbcB) (PDB:1FXX)	Exonuclease C-terminal;Exonuclease	exodeoxyribonuclease I [EC:3.1.11.1]	PF08411.11;PF00929.25
1957	0.24271734004873682	0.14490103755653921	-0.2658245390448597	-0.03552837409300741	0.1252086020345064	-0.06232761874953142	0.04967767199607662	0.1418695547213375	0.027546193824145124	NA	NA	NA	mitochondrial genome maintenance exonuclease 1 [EC:3.1.-.-]	NA
1958	0.05095006953274115	-0.16242423217066884	0.2595096222962018	-0.15964737091702702	0.12326484359039287	-0.060433302178502325	-0.17441103148877882	-0.08843647687815014	0.02988959485654487	General Functional Prediction only	DNA anti-recombination protein (rearrangement mutator) RmuC (RmuC)	RmuC family	DNA recombination protein RmuC	PF02646.17
1959	0.3477180331975259	-0.05018168119205932	0.12386268655447587	-0.19950537385349562	0.2986147800819698	0.19235741769414164	0.075154340746488	-0.2192749678785331	0.06070943516985868	RNA processing and modification	ATP phosphoribosyltransferase (HisG) (PDB:1H3D)	ATP phosphoribosyltransferase	ATP phosphoribosyltransferase [EC:2.4.2.17]	PF01634.19
1960	0.1296857029268413	0.13293078779533077	-0.1650262224711903	-0.03622509611789846	0.10810558004152186	-0.1514269513807206	0.03221990947817303	0.16255445835064875	0.04401316910896897	RNA processing and modification	ATP phosphoribosyltransferase regulatory subunit HisZ (HisZ) (PDB:3OD1) (PUBMED:9767141)	Histidyl-tRNA synthetase	NA	PF13393.7
1961	-0.32425236087440357	0.06275139966657246	-0.32267767762878385	0.10722988288590038	-0.26224777667332544	-0.2414054421280011	-0.10073657951500342	0.36825158208654796	0.06434007867101457	Signal Transduction	Histidyl-tRNA synthetase (HisS) (PDB:1KMM)	Anticodon binding domain;tRNA synthetase class II core domain (G, H, P, S and T);tRNA synthetases class II core domain (F);Histidyl-tRNA synthetase	histidyl-tRNA synthetase [EC:6.1.1.21]	PF03129.21;PF00587.26;PF01409.21;PF13393.7
1962	-0.17195546727012406	-0.10199549372927051	-0.7507146929813708	0.22142973135342997	-0.3161182022183919	-0.2791847491621827	-0.02012141155949281	0.5351248221056842	0.016512168961115653	Signal Transduction	Cold shock protein, CspA family (CspC) (PDB:1C9O)	'Cold-shock' DNA-binding domain;Ribonuclease B OB domain	cold shock protein	PF00313.23;PF08206.12
1963	0.10366047192651773	0.014453928611514996	-0.42914986436934444	-0.08560195813952819	0.024241149060865788	-0.13363140143317384	0.10089483762215548	0.30032671158356944	0.015568337407490944	Signal Transduction	Translation initiation factor IF-1 (InfA) (PDB:5FIM)	Translation initiation factor 1A / IF-1	translation initiation factor IF-1	PF01176.20
1964	-0.23911657996835137	-0.18879961142173995	0.5193736573600755	0.30416970423038414	-0.10201278363741756	0.003591361416147397	0.06270425704679962	-0.23304729831930948	0.0962677709395914	RNA processing and modification	Histidinol dehydrogenase (HisD) (PDB:1K75)	Histidinol dehydrogenase	histidinol dehydrogenase [EC:1.1.1.23]	PF00815.21
1965	0.22204444327144926	0.0551502740039327	-0.14602556969796765	0.053021117351192006	0.1669929449252995	0.07411087539370569	0.20489145742204556	-0.05434780543030178	0.08324233012209109	NA	NA	Protein of unknown function (DUF2948)	NA	PF11164.9
1966	-0.32721618903359273	-0.07226123869183658	0.21756359813662884	0.27256347830139793	-0.2645057563718883	-0.16126537089296802	-0.022509286263105773	0.013459623748963003	0.09137222437429271	Energy production and conversion	UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) (PDB:1A2N)	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	PF00275.21
1967	-0.02643541748879701	0.0831149815750391	-0.06789415335147722	0.12337704854434044	-0.07679933556707472	0.0010416485847841166	0.1655502904519868	0.08089219921776686	0.015697565910249987	Cell motility	dCTP deaminase (Dcd) (PDB:1XS1)	dUTPase	dCTP deaminase [EC:3.5.4.13]	PF00692.20
1968	0.10220688529516364	-0.2191832328324727	0.28967494535204114	-0.31759637874874513	0.15235891460505338	0.14708434323652528	-0.126497381599935	-0.19455119259712286	0.10838679703554915	NA	NA	NA	NA	NA
1969	0.33433774245131664	-0.010732054763101885	-0.03151226106801281	-0.25138781004640937	0.38874598104282526	0.18850101910513273	0.11757789159827181	-0.08560466000272246	0.09832653306695709	NA	NA	NA	NA	NA
1970	0.4743136178635125	0.00854196920067433	-0.142589809517779	-0.1067980417838889	0.4571757874605717	0.10996580535526462	0.09049553888672418	-0.06737984671604455	0.12348938266869793	Nucleotide metabolism and transport	Uncharacterized membrane protein YdjX, related to fungal oxalate transporter, TVP38/TMEM64 family (TVP38) (PUBMED:20889782)	SNARE associated Golgi protein	NA	PF09335.12
1971	-0.08062802561316704	-0.07600805376429556	0.27806517023753197	-0.05403474183656955	0.06316781327929627	0.14953519525737324	-0.14014027355215386	-0.0919739109651158	0.010466026235618917	Signal Transduction	Ribosomal protein L34 (RpmH) (PDB:6SPB)	Ribosomal protein L34	large subunit ribosomal protein L34	PF00468.18
1972	0.298651657907224	0.11644579663940002	-0.4815064286095618	-0.03532771409130745	0.12138931185779156	-0.03322549152252368	0.1325834551125451	0.20050621709341493	0.09595185160358924	Signal Transduction	RNase P protein component (RnpA) (PDB:1A6F)	Ribonuclease P	ribonuclease P protein component [EC:3.1.26.5]	PF00825.19
1973	-0.13720984452931653	0.12299785374022534	-0.26805959515687866	-0.018160073178123435	-0.15517407043174805	-0.06673187989623308	0.08532762645972247	0.22761068336360157	0.12882788065888237	Energy production and conversion	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ (YidD)	Putative membrane protein insertion efficiency factor	uncharacterized protein	PF01809.19
1974	0.20736908059860082	0.06605762229737862	-0.22958124018552523	-0.18843349012482094	0.19655659192804228	0.028969090824965845	0.1270371417831216	0.14042030177117157	0.04141671765983979	Energy production and conversion	Membrane protein insertase Oxa1/YidC/SpoIIIJ (YidC) (PDB:3WO6)	60Kd inner membrane protein;YidC periplasmic domain	YidC/Oxa1 family membrane protein insertase	PF02096.21;PF14849.7
1975	-0.16939413105644058	0.06149713608236316	0.2700759004331643	-0.067928379842963807	-0.016648082787019312	0.06965229361553489	-0.13490944980407166	-0.04235493968348362	0.07171779853230205	RNA processing and modification	N-acetylglutamate kinase (ArgB) (PDB:3S6G)	Amino acid kinase family	acetylglutamate kinase [EC:2.7.2.8]	PF00696.29
1976	0.20174870224428984	0.10753053124855044	-0.30397025362502295	0.10284026447832435	0.04045682396638529	-0.025223719401389736	0.26333119726006343	0.029471201580314275	0.058567191392796404	Energy production and conversion	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis) (YigB) (PDB:4JB3) (PUBMED:24123841)	Haloacid dehalogenase-like hydrolase;haloacid dehalogenase-like hydrolase	putative hydrolase of the HAD superfamily	PF13419.7;PF00702.27
1977	-0.0489909751470314	0.1753418725382908	-0.3131477239500873	0.07842705562375045	-0.1706217585044366	-0.17361438149501932	0.11501108595653443	0.23685779075342198	0.02951257870515689	RNA processing and modification	Tetrahydrodipicolinate N-succinyltransferase (DapD) (PDB:3BXY)	Bacterial transferase hexapeptide (six repeats);Hexapeptide repeat of succinyl-transferase;Tetrahydrodipicolinate N-succinyltransferase N-terminal	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	PF00132.25;PF14602.7;PF14805.7
1979	0.13243032286673442	0.1674911384023993	-0.3428713275741601	-0.010639252894146769	0.04761048881376735	-0.05887328003415509	0.1782140716106012	0.2121699501778704	0.08390169199730775	Function Unknown	Acetoin utilization deacetylase AcuC or a related deacetylase (AcuC) (PDB:1C3P)	Histone deacetylase domain	NA	PF00850.20
1980	0.020129295181283747	0.0947647486104475	-0.35334336145572853	0.017485741269228968	-0.11059058743786407	-0.018106412221100005	0.2906034207325397	0.19092876428928926	0.043475202707678726	Carbohydrate metabolism and transport	SET domain-containing protein (function unknown) (SET) (PDB:6BX3)	SET domain	uncharacterized protein	PF00856.29
1981	0.31237339107694384	0.02198154333554384	-0.42081116522399054	-0.07533545592142689	0.1652793762192498	0.016224483022052504	0.11239517994449813	0.14068646158099937	0.09649050691784065	Signal Transduction	tRNA U38,U39,U40 pseudouridine synthase TruA (TruA) (PDB:1DJ0)	tRNA pseudouridine synthase	tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	PF01416.21
1982	0.22527214250658592	0.013389775169977781	0.031109790524438408	-0.22639915560295543	0.30281586331959487	-0.014499918818261804	-0.06332761736301834	0.017113644461807843	0.07922019090253435	Signal Transduction	Methionyl-tRNA formyltransferase (Fmt) (PDB:1FMT)	Formyl transferase, C-terminal domain;Formyl transferase	methionyl-tRNA formyltransferase [EC:2.1.2.9]	PF02911.19;PF00551.20
1984	0.32078360991154026	0.03568460278335227	0.09480978672309459	-0.2436334845356433	0.3325644063710235	0.10001538341275597	0.04378009078540101	-0.1259447591511833	0.0947042116152522	NA	NA	NA	NA	NA
1985	-0.11649977316137755	-0.014829673245790556	-0.32223182226042957	0.02770786718812087	-0.1930155457709506	-0.40969643562894487	-0.06433591266543452	0.21687170189760907	0.14849042659716524	NA	NA	NA	NA	NA
1986	-0.4818028490720963	0.031862491069082365	0.44942177157597274	0.21258573979916545	-0.36094700779953953	-0.15565328899064287	-0.2280752064551065	-0.07107952398044934	0.12389729301167685	RNA processing and modification	Shikimate kinase (AroK) (PDB:1E6C)	Shikimate kinase	shikimate kinase [EC:2.7.1.71]	PF01202.23
1987	-0.07893630868569808	-0.044033067377469946	0.1198108756273968	-0.037322778551390205	-0.06938085952999318	0.08352331471982868	0.034320075532481543	-0.005858352417697026	0.14948347629225262	RNA processing and modification	3-dehydroquinate synthetase (AroB) (PDB:3ZOK)!!!Shikimate kinase (AroK) (PDB:1E6C)	3-dehydroquinate synthase;Iron-containing alcohol dehydrogenase;Iron-containing alcohol dehydrogenase	3-dehydroquinate synthase [EC:4.2.3.4]	PF01761.21;PF00465.20;PF13685.7
1988	0.34520582155170065	0.04915319665063999	-0.3746795210577003	-0.10472459904403077	0.2791007354375997	-0.08498093770169696	0.08039450715005438	0.16714340161271202	0.13665693293729256	Signal Transduction	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation (BolA) (PDB:2DHM) (PUBMED:19111750;2569159)	BolA-like protein	BolA family transcriptional regulator, general stress-responsive regulator	PF01722.19
1989	-0.3951544171782775	-0.02635177471743325	-0.43810872985525295	0.2830481186853081	-0.38895817579179426	-0.31406246404155075	0.0715792353273473	0.44856958567433247	0.05029616873455361	Inorganic ion transport and metabolism	DnaJ-class molecular chaperone with C-terminal Zn finger domain (DnaJ) (PDB:1BQ0)	DnaJ domain	NA	PF00226.32
1990	-0.14976809669242752	-0.006895723939471636	-0.4761830162848835	0.27176729614432316	-0.29532323522138804	-0.2228951027989174	0.09724405285402113	0.33383490415446276	0.0182171584956387	Carbohydrate metabolism and transport	MoxR-like ATPase (MoxR) (PDB:2R44)	AAA domain (dynein-related subfamily);Cobaltochelatase CobS subunit N terminal	cobaltochelatase CobS [EC:6.6.1.2]	PF07728.15;PF12556.9
1991	0.3372560802159479	0.04982861348118694	-0.08320882907217486	-0.06824730830885924	0.2952432957441436	0.025626147244510816	0.06933354920591529	-0.03338539028097845	0.03182082551426157	Energy production and conversion	Cobalamin biosynthesis cobaltochelatase CobT subunit (CobT2)	Cobalamin biosynthesis protein CobT;Cobalamin biosynthesis protein CobT VWA domain	cobaltochelatase CobT [EC:6.6.1.2]	PF06213.13;PF11775.9
1992	0.17514514144402313	-0.02351298844698081	-0.23123370691496414	-0.15801518366624037	0.22835034985605718	-0.08822961457108332	-0.01869427311383624	0.13483051528235246	0.0681279411532393	Function Unknown	Signal transduction histidine kinase (BaeS) (PDB:1JOY)	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	two-component system, sensor histidine kinase RegB [EC:2.7.13.3]	PF02518.27
1993	0.1398367273934829	0.07044530031474312	0.12345225459020025	-0.035655845396936094	0.1154392565948031	0.09724278850665129	-0.030737523734431803	-0.09368498241819377	0.03079041515932881	General Functional Prediction only	DNA gyrase/topoisomerase IV, subunit B (GyrB) (PDB:1EI1)	DNA gyrase B;DNA gyrase B subunit, carboxyl terminus;Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase;Toprim domain	DNA gyrase subunit B [EC:5.6.2.2]	PF00204.26;PF00986.22;PF02518.27;PF01751.23
1999	0.21098884259338	0.078812692326143	-0.36895839399195685	0.18492920649982153	0.06081906676769709	-0.07953632400791721	0.2668767534187666	0.12392516861359093	0.022952935934870536	Signal Transduction	Translation elongation factor EF-4, membrane-bound GTPase (LepA) (PDB:3DEG)	Elongation factor G C-terminus;Elongation Factor G, domain III;Elongation factor Tu GTP binding domain;Elongation factor Tu domain 2;GTP-binding protein LepA C-terminus	GTP-binding protein LepA	PF00679.25;PF14492.7;PF00009.28;PF03144.26;PF06421.13
2000	0.03228071977421006	-0.01440074301047367	-0.047663203586933704	-0.013098671694729577	0.08722200908852341	-0.008810182633448259	0.07910271016693718	0.08173247564726792	0.10079468091015048	Signal Transduction	Phenylalanyl-tRNA synthetase beta subunit (PheT) (PDB:3L4G)!!!tRNA-binding EMAP/Myf domain (EMAP) (PDB:1MKH)	B3/4 domain;tRNA synthetase B5 domain;Ferredoxin-fold anticodon binding domain;Putative tRNA binding domain;Phenylalanyl tRNA synthetase beta chain CLM domain	phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	PF03483.18;PF03484.16;PF03147.15;PF01588.21;PF17759.2
2001	0.3410231829774094	0.0828236792373634	-0.389356009657487	-0.04480938447174013	0.17254536180088778	-0.03854005584488739	0.10791257318207764	0.14821473769473423	0.048043661417353604	Signal Transduction	Phenylalanyl-tRNA synthetase alpha subunit (PheS) (PDB:3L4G)	Aminoacyl tRNA synthetase class II, N-terminal domain;tRNA synthetases class II core domain (F)	phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	PF02912.19;PF01409.21
2003	-0.025964284821964424	-0.04210718620705152	-0.5541907380671267	0.1195519595942944	-0.10159345230726206	-0.15927388574702925	0.09488051178831086	0.35098829122432096	0.011910705841911243	Signal Transduction	Ribosomal protein L35 (RpmI) (PDB:1VS6) (PUBMED:28373563)	Ribosomal protein L35	large subunit ribosomal protein L35	PF01632.20
2004	-0.07848921592403746	0.10278743866268737	-0.12726679189891724	0.00223451550399385	-0.05022001584768773	0.04837362160517964	0.0755453053166329	0.15302732729544635	0.01995713865467707	Signal Transduction	Translation initiation factor IF-3 (InfC) (PDB:2IFE)	Translation initiation factor IF-3, C-terminal domain;Translation initiation factor IF-3, N-terminal domain	translation initiation factor IF-3	PF00707.23;PF05198.17
2005	0.37394046280031606	0.05596767745134423	-0.13063240306622756	-0.1976999200707851	0.3784626161175324	0.05903972686449265	0.036206746024673685	0.010011015679563263	0.038202281457390116	Signal Transduction	Threonyl-tRNA synthetase (ThrS) (PDB:1NYQ)	Anticodon binding domain;TGS domain;tRNA synthetase class II core domain (G, H, P, S and T);Threonyl and Alanyl tRNA synthetase second additional domain	threonyl-tRNA synthetase [EC:6.1.1.3]	PF03129.21;PF02824.22;PF00587.26;PF07973.15
2006	0.21196344192432892	-0.012564155979428554	0.04403385938747046	-0.1348167238646507	0.2705959867174405	-0.03074422824628361	-0.057539579409491906	-0.01970788207643833	0.05973573229050282	Energy production and conversion	Glycosyltransferase involved in cell wall bisynthesis (RfaB) (PDB:2IV7)	Glycosyl transferases group 1;Glycosyltransferase Family 4;Glycosyl transferases group 1	NA	PF00534.21;PF13439.7;PF13692.7
2007	0.0033705185158700774	0.007924114784557653	-0.13454355523989	-0.015685536638859757	-0.058695383974503544	-0.07663023396039056	0.10248511471871956	0.12774107841117768	0.0920142006044967	Energy production and conversion	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold (MenH) (PDB:4MYS)	alpha/beta hydrolase fold;Phospholipase/Carboxylesterase;Serine aminopeptidase, S33	NA	PF00561.21;PF02230.17;PF12146.9
2011	-0.3609108952243711	0.18109370465481897	0.06464805822216799	0.31314144383658676	-0.3521950021833073	-0.013262301118801077	0.05055566465214516	0.10914468613212913	0.05441341349308353	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	NA	PF00892.21
2012	0.027026385256174373	0.07949207054235174	0.06658975999071223	-0.03296336267355349	0.041100989614634514	0.18346621123379422	0.14031103000643583	-0.04865214411757565	0.10973190915175303	Amino Acid metabolis and transport	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component (AceF) (PDB:1B5S)	2-oxoacid dehydrogenases acyltransferase (catalytic domain);Biotin-requiring enzyme;Biotin-lipoyl like;e3 binding domain;Pyrimidine nucleoside phosphorylase C-terminal domain	pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]	PF00198.24;PF00364.23;PF13533.7;PF02817.18;PF07831.14
2013	0.04593730450591088	0.036385294449057165	-0.2748550289111397	0.05209282910091696	-0.0329124550555901	0.025660989376192964	0.27680225830067906	0.1136053171808445	0.04433484203834615	Amino Acid metabolis and transport	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component (AceF) (PDB:1B5S)!!!Pyruvate dehydrogenase complex, dehydrogenase (E1) component (AceE) (PDB:1L8A)	Biotin-requiring enzyme;Biotin-lipoyl like;Pyruvate dehydrogenase E1 component middle domain;Pyrimidine nucleoside phosphorylase C-terminal domain;Transketolase, thiamine diphosphate binding domain	pyruvate dehydrogenase E1 component [EC:1.2.4.1]	PF00364.23;PF13533.7;PF17831.2;PF07831.14;PF00456.22
2014	-0.2836125533009539	0.15270107347381018	0.08445349550165102	0.11007764467212741	-0.2039410021117969	-0.03438761292785889	0.050537364087334294	0.08304404535839673	0.07554338343128184	Replication and repair	Acetyl-CoA acetyltransferase (PaaJ) (PDB:1AFW)	Thiolase, C-terminal domain;Thiolase, N-terminal domain	acetyl-CoA C-acetyltransferase [EC:2.3.1.9]	PF02803.19;PF00108.24
2015	0.5237023592964514	0.15517522451724522	-0.2019454445892559	-0.19193391166961027	0.4153001401851597	0.10697702614399122	0.08014706341834815	-0.04905844222253328	0.08386639241151826	Function Unknown	Acyl-CoA thioesterase PaaI, contains HGG motif (PaaI) (PDB:1PSU)	Thioesterase superfamily	NA	PF03061.23
2016	-0.1458246601718511	0.04550118545460786	0.4612615939819821	0.01006236522312252	-0.06684234204474564	0.06018175003542868	0.007926972834614857	-0.23263043175224982	0.1218358313884618	Replication and repair	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase (Acs) (PDB:4B2O) (PUBMED:14638756)	AMP-binding enzyme;AMP-binding enzyme C-terminal domain	acetoacetyl-CoA synthetase [EC:6.2.1.16]	PF00501.29;PF13193.7
2017	0.037958593374806594	-0.036797442318948305	-0.00808809686231358	0.0872988203779693	0.035792104471360185	-0.10445610881597699	0.03407595714264294	0.03158437162726621	0.060077632283059366	General Functional Prediction only	Superfamily II RNA helicase (Dob10) (PDB:4A4Z)	Helicase conserved C-terminal domain	ATP-dependent RNA helicase SUPV3L1/SUV3 [EC:3.6.4.13]	PF00271.32
2018	-0.3851511431211233	0.11772724977274401	0.12384512935949231	0.07962414660866882	-0.28294752586051314	-0.061978272122354745	-0.12746628009381347	0.12516118286014805	0.15285601767937318	Lipid metabolism	Tellurite resistance protein TerB (TerB2) (PDB:2JXU) (PUBMED:23044854)	Tellurite resistance protein TerB	NA	PF05099.14
2019	0.3474176546347869	0.03230888555687604	-0.16222664610655407	-0.18230245668333758	0.37710482789616545	0.018731237698020917	0.006071494727872595	0.07832776910855244	0.03692366107173673	Cell motility	NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit (PreA)	Domain of unknown function (DUF3470);4Fe-4S binding domain;4Fe-4S dicluster domain;4Fe-4S double cluster binding domain;4Fe-4S binding domain;4Fe-4S binding domain;4Fe-4S dicluster domain	ferredoxin	PF11953.9;PF00037.28;PF13237.7;PF13484.7;PF12800.8;PF12837.8;PF12838.8
2020	-0.17737034965438758	0.08210613926914317	0.14319463193537077	0.2603708473383342	-0.236360469427153	-0.12332093642599797	0.1791078980912422	-0.09768356367858134	0.1445952396437565	Signal Transduction	RNA polymerase-interacting regulator, CarD/CdnL/TRCF family (CdnL) (PDB:4ILU)	CarD-like/TRCF domain	CarD family transcriptional regulator	PF02559.17
2022	-0.38060695565890146	0.12088872983022243	0.22467579808793328	0.1957853855877723	-0.3328278434113842	-0.022639002899051297	-0.10545909861196509	0.04774884992374927	0.07730901516833473	Replication and repair	Long-chain acyl-CoA synthetase (AMP-forming) (FAA1)	AMP-binding enzyme	long-chain acyl-CoA synthetase [EC:6.2.1.3]	PF00501.29
2023	-0.4612358555246563	0.11941445742888156	-0.204828255391131	0.05084013858028225	-0.28444186119896014	-0.23237418600263063	-0.050585916441083977	0.3724292129941248	0.10080505258292406	Nucleotide metabolism and transport	Uncharacterized membrane protein YqaA, VTT domain (YgaA)	NA	NA	NA
2026	-0.37150416753445786	-0.0013480100942751955	0.0014307485848777004	0.306032422293373	-0.3948942124501551	-0.0981081772041697	0.004215057573825414	0.07680373048727342	0.0198668072970025	Cell cycle control and mitosis	5-methylcytosine-specific restriction endonuclease McrA (McrA)	HNH endonuclease;HNH endonuclease;HNH endonuclease	5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]	PF01844.24;PF13395.7;PF14279.7
2027	0.04749708452928126	-0.10314757754063594	-0.09862811678227751	-0.024577615507561046	0.11484053209754495	-0.21704038991871724	-0.09971513957360953	0.10367587477745933	0.1000204530768557	Carbohydrate metabolism and transport	Predicted esterase (YpfH)	alpha/beta hydrolase fold;Phospholipase/Carboxylesterase;Dienelactone hydrolase family;Serine hydrolase (FSH1);Prolyl oligopeptidase family	phospholipase/carboxylesterase	PF00561.21;PF02230.17;PF01738.19;PF03959.14;PF00326.22
2028	0.274966572294741	0.026847201313365505	0.15336103673080764	-0.17651138064463673	0.33567814153035624	0.034384112996256794	-0.10656721050934306	-0.10961452959444765	0.06596760711084464	NA	NA	Hypoxia induced protein conserved region	NA	PF04588.14
2029	-0.26190486795849643	-0.06700365938872875	-0.320054583246705	0.4152451380257662	-0.4017465945235204	-0.10663063725812554	0.12499519566878604	0.1836021643602805	0.2160590548717226	Inorganic ion transport and metabolism	Thiol-disulfide isomerase or thioredoxin (TrxA) (PDB:1XFL)	AhpC/TSA family;Redoxin;Thioredoxin;Thioredoxin-like domain;Thioredoxin-like	cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE	PF00578.22;PF08534.11;PF00085.21;PF13098.7;PF13905.7
2030	-0.007771178003784843	-0.12345092455705274	0.16758691478038287	-0.1985651455207006	0.12959125710213468	0.03300800739195623	0.015217443856191145	-0.06103828640067389	0.072609412298446	RNA processing and modification	Argininosuccinate lyase (ArgH) (PDB:1AOS)	Argininosuccinate lyase C-terminal;Lyase	argininosuccinate lyase [EC:4.3.2.1]	PF14698.7;PF00206.21
2031	-0.13202173608605186	-0.06373084782559696	0.24331975148056886	-0.18822145052184852	-0.014036556600074229	-0.06274625985816303	-0.17604488421856526	-0.06094131312008795	0.5391173884630942	NA	NA	NA	NA	NA
2032	0.31375017878959416	0.009598683437830295	0.10389503515380627	-0.20761167464597935	0.4150611970006213	0.1339457948737651	-0.05545417483871932	-0.179958900077189	0.09746404585234421	RNA processing and modification	Diaminopimelate decarboxylase (LysA) (PDB:1D7K)	Pyridoxal-dependent decarboxylase, pyridoxal binding domain;Pyridoxal-dependent decarboxylase, C-terminal sheet domain	diaminopimelate decarboxylase [EC:4.1.1.20]	PF02784.17;PF00278.23
2033	0.22616065295659213	-0.04055295752927293	-0.01977570188898348	-0.26368334678088645	0.26028648504649843	0.07501823044541317	-0.020088765677463708	0.023586039754819866	0.13534565843025081	Replication and repair	1-acyl-sn-glycerol-3-phosphate acyltransferase (PlsC) (PDB:1IUQ)	Acyltransferase	1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	PF01553.22
2034	0.1834975298877403	0.026938349272738426	-0.1423696245340719	0.007239180050730255	0.1452202393526309	0.054013956440517125	0.19593696601605018	0.0528345338712798	0.03111496644603507	General Functional Prediction only	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog (DnaN) (PDB:1JQJ)	DNA polymerase III beta subunit, N-terminal domain;DNA polymerase III beta subunit, central domain;DNA polymerase III beta subunit, C-terminal domain	DNA polymerase III subunit beta [EC:2.7.7.7]	PF00712.20;PF02767.17;PF02768.16
2035	-0.3903239185862402	-0.034271514990258385	0.5723866834583902	0.16179308775065432	-0.18717409232918372	0.07371275228367659	-0.10777976240947655	-0.21036900099203418	0.05714507783899997	General Functional Prediction only	Chromosomal replication initiation ATPase DnaA (DnaA) (PDB:1L8Q)	ATPase family associated with various cellular activities (AAA);AFG1-like ATPase;Bacterial dnaA  protein;Bacterial dnaA protein helix-turn-helix;DnaA N-terminal domain;IstB-like ATP binding protein	chromosomal replication initiator protein	PF00004.30;PF03969.17;PF00308.19;PF08299.12;PF11638.9;PF01695.18
2036	0.22921237296081468	0.034895755082519415	-0.1857702418688342	-0.08573097590047746	0.23346459624213764	0.016427895301172724	0.07218272665126861	0.06143405666305739	0.04777685015689515	Signal Transduction	Ribosomal protein S20 (RpsT) (PDB:4V4H)	Ribosomal protein S20	small subunit ribosomal protein S20	PF01649.19
2037	0.028997382287916793	0.0770670516464762	-0.2046171975369146	0.07964796903655628	-0.09737673560332012	-0.12119748155805554	0.06563496647683023	0.17289938668740798	0.14079320140304477	General Functional Prediction only	Formamidopyrimidine-DNA glycosylase (Nei) (PDB:1EE8)	Formamidopyrimidine-DNA glycosylase N-terminal domain;Formamidopyrimidine-DNA glycosylase H2TH domain	formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]	PF01149.25;PF06831.15
2038	0.06681329581965384	0.05909262015304841	-0.2679323979172335	0.1648182738311019	0.007100073216290348	-0.062449395223375885	0.19603380755483693	0.15801538041836302	0.08669676066115986	Energy production and conversion	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG (UbiE) (PDB:4OBW)	Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase small domain;ubiE/COQ5 methyltransferase family	demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	PF08241.13;PF08242.13;PF13489.7;PF13649.7;PF13847.7;PF05175.15;PF01209.19
2039	0.21331632707080317	0.08059299656589142	-0.43092674825248195	-0.018194691838800292	0.12042477126246916	-0.11249640944895681	0.07941532917380519	0.2643969288577553	0.03172084838455451	Energy production and conversion	Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family (AarF) (PDB:4PED)	ABC1 family;RIO1 family	ubiquinone biosynthesis protein	PF03109.17;PF01163.23
2040	-0.5246929961420327	-0.07490044885871822	0.47104991095383497	0.18580288948429463	-0.332974599165261	-0.020617760811898988	-0.15198460900702168	-0.08769048815398965	0.11881123920274558	Energy production and conversion	Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC (CoaBC) (PDB:3QJG)	DNA / pantothenate metabolism flavoprotein;Flavoprotein	phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]	PF04127.16;PF02441.20
2041	0.4375123374716338	0.09050175805281203	-0.2594083214363767	-0.24051426596431447	0.42748365894931645	0.11989128949133984	0.060696340000060724	0.043532731622377294	0.06857315761053082	Cell motility	dUTP pyrophosphatase (dUTPase) (Dut) (PDB:1DUC)	dUTPase	dUTP pyrophosphatase [EC:3.6.1.23]	PF00692.20
2042	-0.36433444690264927	-0.06854688180335353	0.40077455288587094	0.04321499296240377	-0.20009302301883752	-0.14237151155660044	-0.09019735784800412	-0.06309079770539212	0.10182651567298256	Energy production and conversion	Molybdopterin or thiamine biosynthesis adenylyltransferase (ThiF) (PDB:1ZUD) (PUBMED:32239579)	ThiF family	NA	PF00899.22
2043	0.24972042910449424	-0.030689796128249364	0.23574082734757765	-0.23777090948829482	0.31968048190173537	0.051315552877149055	-0.1218183670377404	-0.14471351827959394	0.09113639797366495	Nucleotide metabolism and transport	SH3-like domain (SH3)	Bacterial SH3 domain;Bacterial SH3 domain	NA	PF08239.12;PF06347.14
2048	0.2905215121263212	0.09321173913539316	-0.4842080603045348	-0.08949419274773962	0.13972956151907112	0.03740032179830782	0.14743524893019475	0.2072085093222351	0.06561826155714633	Replication and repair	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase (FabA) (PDB:1MKA)	FabA-like domain	3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:4.2.1.59 5.3.3.14]	PF07977.14
2049	0.13308546107738836	0.05897293220728562	-0.3453983343930378	-0.040475359760226495	0.08144807836213003	-0.0445715778520748	0.1592976772011138	0.17172428477942117	0.03149839829916312	Replication and repair	3-oxoacyl-(acyl-carrier-protein) synthase (FabB) (PDB:2UV8) (PUBMED:21652641)	Beta-ketoacyl synthase, N-terminal domain;Beta-ketoacyl synthase, C-terminal domain	3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41]	PF00109.27;PF02801.23
2052	0.23231544753470948	0.15091476813271884	-0.5122075519744592	0.05607006780446424	0.03936815078643122	-0.07486626186175288	0.1063471281600119	0.2845640779696221	0.02617405928843489	Signal Transduction	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (Pnp) (PDB:1E3P)	KH domain;Polyribonucleotide nucleotidyltransferase, RNA binding domain;3' exoribonuclease family, domain 1;3' exoribonuclease family, domain 2;S1 RNA binding domain	polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	PF00013.30;PF03726.15;PF01138.22;PF03725.16;PF00575.24
2054	0.21350610704753983	-0.04734896700289632	-0.4850335792602567	0.01985864844642522	0.12256481628347814	-0.009618690608296636	0.05130303741972167	0.19249484435102363	0.034621214750391774	Signal Transduction	Ribosome-binding factor RbfA (RbfA) (PDB:1JOS)	Ribosome-binding factor A	ribosome-binding factor A	PF02033.19
2055	0.19049039037551393	-0.16063425585612617	-0.08833300514391619	-0.0466206307129222	0.10003259005232726	0.12385624830785952	0.09865524897895335	-0.0012647803249316032	0.04367454052992362	Signal Transduction	Translation initiation factor IF-2, a GTPase (InfB) (PDB:5ME0)	ADP-ribosylation factor family;Ferrous iron transport protein B;Elongation factor Tu GTP binding domain;Translation-initiation factor 2;Translation initiation factor IF-2, N-terminal region;50S ribosome-binding GTPase;Ras family;Signal recognition particle receptor beta subunit	translation initiation factor IF-2	PF00025.22;PF02421.19;PF00009.28;PF11987.9;PF04760.16;PF01926.24;PF00071.23;PF09439.11
2056	0.23627078188082468	-0.001912911311728415	-0.09630654548086892	-0.07731858980251705	0.19662488815098114	0.10179573604640783	0.04443130076249975	0.019373169391697326	0.02531401128401449	Signal Transduction	Transcription antitermination factor NusA, contains S1 and KH domains (NusA) (PDB:1HH2)	Helix-hairpin-helix domain;KH domain;NusA-like KH domain;NusA N-terminal domain;S1 RNA binding domain	transcription termination/antitermination protein NusA	PF14520.7;PF07650.18;PF13184.7;PF08529.12;PF00575.24
2057	0.3194728382226088	-3.389047324415826e-4	-0.29830615934403937	-0.141591304547715	0.2708137937250256	-0.013660548116805447	0.06605445324406006	0.11412050670634481	0.036627990448588235	Energy production and conversion	S-adenosylmethionine synthetase (MetK) (PDB:1FUG)	S-adenosylmethionine synthetase, C-terminal domain;S-adenosylmethionine synthetase, central domain;S-adenosylmethionine synthetase, N-terminal domain	S-adenosylmethionine synthetase [EC:2.5.1.6]	PF02773.17;PF02772.17;PF00438.21
2058	0.3507031850281218	0.08152261653768456	-0.03735034412039843	-0.12669433649903558	0.34572505290418976	-0.001553295330768464	0.11371845513366095	-0.09838734828659684	0.14402179030919104	Energy production and conversion	Apolipoprotein N-acyltransferase (Lnt) (PDB:6NWR)	Carbon-nitrogen hydrolase	apolipoprotein N-acyltransferase [EC:2.3.1.269]	PF00795.23
2059	-0.1289116030031677	0.06649154589067224	0.05408824732821666	0.15891179342025316	-0.1686706802763328	0.012284841740974358	-0.15193889664470864	0.01902460233452948	0.13760856894167525	Signal Transduction	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme (YbeY) (PDB:1XM5) (PUBMED:17407324;23543739)	Uncharacterized protein family UPF0054	probable rRNA maturation factor	PF02130.18
2060	0.27509653659794286	0.08654412946115515	-0.3766607013317057	-0.06961090881062895	0.22622279482311292	-0.01337091618511369	0.07373298994315834	0.15247191311230812	0.024282222010593244	Function Unknown	Phosphate starvation-inducible protein PhoH, predicted ATPase (PhoH) (PDB:3B85) (PUBMED:8444794;12762842)	AAA domain;AAA domain;PhoH-like protein	phosphate starvation-inducible protein PhoH and related proteins	PF13245.7;PF13604.7;PF02562.17
2061	0.3113374868571054	0.11044102718903732	-0.20230916117070943	-0.03354088388199014	0.23716037633829326	2.3955559421784143e-4	0.02604913850569132	0.0799257209689028	0.0976526766492676	Signal Transduction	tRNA A37 methylthiotransferase MiaB (MiaB) (PDB:4JC0) (PUBMED:17407324;20472640;20584901)	Radical SAM superfamily;TRAM domain;TRAM domain;Uncharacterized protein family UPF0004	tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	PF04055.22;PF01938.21;PF18693.2;PF00919.21
2063	0.2830887686148578	0.06159874547368443	-0.17991941870290645	0.010533147663711832	0.1766988461186829	-0.07729442405879165	-0.026735099923403602	0.07208685309736647	0.12510097653273108	NA	NA	NA	NA	NA
2064	0.18287544122463267	-0.12950157115408803	0.18849235959201274	-0.02243802355773786	0.20074276717636474	0.29129135337343803	0.14324472768420712	-0.28281713161394295	0.11236027863363776	Energy production and conversion	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family (CDA1) (PDB:1NY1)	Polysaccharide deacetylase	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase [EC:3.5.1.-]	PF01522.22
2066	-0.027410759594472728	0.14365322000993955	0.2474670166777532	0.07906653157580949	-0.044207113816744456	0.10517530341384096	0.045914240785827384	-0.1287370551897987	0.08712088792831157	Inorganic ion transport and metabolism	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain (NifU) (PDB:2Z51)	Scaffold protein Nfu/NifU N terminal;NifU-like domain	NFU1 iron-sulfur cluster scaffold homolog, mitochondrial	PF08712.12;PF01106.18
2067	-0.49328169927793186	-0.009595981553560751	0.31313448528117216	0.28204083352775794	-0.4307300871662804	-0.16304664581826783	-0.17441591769561426	0.06736550449181838	0.06200025662754392	Signal Transduction	Tryptophanyl-tRNA synthetase (TrpS) (PDB:3N9I)	tRNA synthetases class I (W and Y)	tryptophanyl-tRNA synthetase [EC:6.1.1.2]	PF00579.26
2068	0.19672973473304695	0.16144021816114315	0.050376317142476035	-0.29219912459222896	0.3897449944074946	0.11505668433597166	-0.07929905847357456	0.025557503189399852	0.05929306907453895	Energy production and conversion	Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) (MurJ) (PDB:5T77) (PUBMED:25013077)	MatE;Lipid II flippase MurJ;Polysaccharide biosynthesis C-terminal domain	putative peptidoglycan lipid II flippase	PF01554.19;PF03023.15;PF14667.7
2069	0.07645271145111938	0.03263683708136063	-0.34198208463345553	0.040430213315930136	0.08565626746752483	-0.10257975476886051	0.07774225523207264	0.20610317180135895	0.03602628970440424	Amino Acid metabolis and transport	Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) (Pta) (PDB:1QZT) (PUBMED:28754323)!!!Malic enzyme (SfcA) (PDB:1DO8)	Malic enzyme, N-terminal domain;Malic enzyme, NAD binding domain;Phosphate acetyl/butaryl transferase	malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38];malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]	PF00390.20;PF03949.16;PF01515.20
2071	0.1571403215006372	0.0030095227256518873	-0.14619776813328636	0.0027964770662000913	0.05224562494659176	-0.08896577391370136	0.14293776214801635	-1.6164196866164316e-4	0.13723295657067044	Signal Transduction	16S rRNA C1402 (ribose-2'-O) methylase RsmI (RsmI) (PDB:3KWP) (PUBMED:24078611)	Tetrapyrrole (Corrin/Porphyrin) Methylases	16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]	PF00590.21
2072	-0.3681679947105162	-0.017090020155556045	0.06749919940467049	0.027826391738693317	-0.25720436711809763	0.018654410546659554	-0.01484640883070175	-0.010442338109307833	0.08872380406491953	RNA processing and modification	ABC-type branched-chain amino acid transport system, periplasmic component (LivK) (PDB:1USG)	NA	NA	NA
2073	0.025677786525462314	-0.20748160598789336	0.028047713240150946	-0.14075889021227983	0.02058883496846555	0.08240499424529579	0.144491930038786	-0.05725218240750323	0.10338101665204297	Cell motility	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family (RdgB) (PDB:1B78)	Ham1 family	XTP/dITP diphosphohydrolase [EC:3.6.1.66]	PF01725.17
2074	0.3286718470456122	-0.1297970016871399	0.11136982613632254	-0.004276065439922489	0.2683147383552948	0.12123169936152495	0.07084256434511846	-0.36858322021501483	0.07505992011438667	Inorganic ion transport and metabolism	Molecular chaperone GrpE (heat shock protein HSP-70) (GrpE) (PDB:1DKG)	GrpE	molecular chaperone GrpE	PF01025.20
2075	0.23338922132098708	0.05332610885430982	-0.5912211013378144	0.09073183537586985	0.08933763488996671	-0.100854233198086	0.2691368344576984	0.23836094602342825	0.022694992787118794	Inorganic ion transport and metabolism	Molecular chaperone DnaK (HSP70) (DnaK) (PDB:3I33)	Hsp70 protein;MreB/Mbl protein	molecular chaperone DnaK	PF00012.21;PF06723.14
2076	0.05641924587163557	0.10603268336785057	-0.4873737005881201	0.045971451091764766	0.013907924114740861	-0.17254680975732212	0.09041610444803934	0.3477547536608722	0.022252937894731175	Inorganic ion transport and metabolism	DnaJ-class molecular chaperone with C-terminal Zn finger domain (DnaJ) (PDB:1BQ0)	DnaJ domain;DnaJ C terminal domain;DnaJ central domain	molecular chaperone DnaJ	PF00226.32;PF01556.19;PF00684.20
2080	-0.016477485272703055	0.04058657540335761	-0.47119243495503205	0.024310267389891352	-0.09942826361102339	-0.1539544114414428	-0.095341938484768	0.3754013697881414	0.07843750502135516	Energy production and conversion	Sugar or nucleoside kinase, ribokinase family (RbsK) (PDB:2QCV)	pfkB family carbohydrate kinase	adenosine kinase [EC:2.7.1.20]	PF00294.25
2081	0.23201623034977467	-0.03568874870096825	-0.34235145094412955	-0.1597651732939666	0.2019730617014357	-0.038688480997644846	-0.0012731073252136794	0.19494290555755303	0.0681216013470577	NA	NA	NA	NA	NA
2110	0.18866062637730233	0.0702435587441869	-0.4001597242587248	0.06735888381507828	0.0228465249498496	-0.023400158811237345	0.3055068169505037	0.13193720119478883	0.034312481039264105	Inorganic ion transport and metabolism	ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU (HslU) (PDB:1DO0)	ATPase family associated with various cellular activities (AAA);AAA domain (Cdc48 subfamily);AAA domain (dynein-related subfamily);C-terminal, D2-small domain, of ClpB protein;Magnesium chelatase, subunit ChlI;Sigma-54 interaction domain	ATP-dependent HslUV protease ATP-binding subunit HslU	PF00004.30;PF07724.15;PF07728.15;PF10431.10;PF01078.22;PF00158.27
2111	-0.06354186899445018	-0.0481016636744939	-0.4739326924778972	0.2800877326166134	-0.18991562341672283	-0.1883208597813736	0.044820870637934725	0.26222178148747366	0.019308842939259496	Inorganic ion transport and metabolism	ATP-dependent protease HslVU (ClpYQ), peptidase subunit (HslV) (PDB:5JI3)	Proteasome subunit	ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]	PF00227.27
2113	-0.009482600640786909	0.16168330520737817	0.08516062153739856	-0.17505735525302993	0.06810552458099284	-0.07824657053348022	-0.08822132605596986	0.06674032158688513	0.016317232408936934	RNA processing and modification	Imidazoleglycerol phosphate dehydratase HisB (HisB2) (PDB:1RHY)	Imidazoleglycerol-phosphate dehydratase	imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]	PF00475.19
2114	0.2808652039445901	0.1260934343147634	0.321247442203767	0.04427682849481763	0.2935028013281794	0.1504571853885198	-0.06300137830316421	-0.23120048035474677	0.0691707721396771	RNA processing and modification	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH (HisH) (PDB:1OX4)	Glutamine amidotransferase class-I;Peptidase C26;SNO glutamine amidotransferase family	imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10]	PF00117.29;PF07722.14;PF01174.20
2115	0.19386315084595884	-0.033333911423420015	-0.12697659539541192	0.04976231525088582	0.05064295437579003	-0.014551287961730767	0.11989958411734998	-0.07881933058767353	0.06979760722007596	RNA processing and modification	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) (PDB:4U28)	Dihydrouridine synthase (Dus);Histidine biosynthesis protein	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]	PF01207.18;PF00977.22
2116	0.01369479826661566	0.044883288425095966	0.2513200074873927	0.0033154357165697144	0.01886754033643482	0.11461764939591339	-0.09201679544468382	-0.06100709291382736	0.04441095931604233	RNA processing and modification	Imidazole glycerol phosphate synthase subunit HisF (HisF) (PDB:1OX4)	Dihydroorotate dehydrogenase;Dihydrouridine synthase (Dus);Histidine biosynthesis protein;Nitronate monooxygenase;Thiazole biosynthesis protein ThiG	imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10]	PF01180.22;PF01207.18;PF00977.22;PF03060.16;PF05690.15
2118	0.3098239296599665	0.044278566540135504	-0.3821671132390119	0.05914645639819668	0.19714709032813107	-0.10129611398904885	0.09377241792974618	0.10177573537946533	0.038403373792065265	Cell motility	Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family (HinT) (PDB:1AV5) (PUBMED:20934431)	Scavenger mRNA decapping enzyme C-term binding;HIT domain	histidine triad (HIT) family protein	PF11969.9;PF01230.24
2125	-0.06747281579319006	0.018107165507708016	-0.2841338772044568	-0.06388611185770228	0.03284168472920051	-0.1490516116898333	0.01576671114641101	0.3007362265422513	0.10256278556884801	Energy production and conversion	Pterin-4a-carbinolamine dehydratase (PhhB) (PDB:1DCH)	Pterin 4 alpha carbinolamine dehydratase	4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]	PF01329.20
2126	0.2320015295433402	0.09492980640748483	-0.04662962505202683	-0.10315887820079797	0.26487617670625785	2.0026249822728038e-4	0.14487949706249328	-0.003681745915466835	0.10699274233120096	Cell motility	AICAR transformylase/IMP cyclohydrolase PurH (PurH) (PDB:1G8M)	AICARFT/IMPCHase bienzyme;MGS-like domain	phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	PF01808.19;PF02142.23
2127	0.15600332890791535	-0.04227532444173838	0.25918706981025696	-0.3261290433042315	0.2819832797226361	0.16489189287385883	-0.2596153933236726	-0.10473823612592054	0.10856394336432051	Carbohydrate metabolism and transport	Uncharacterized conserved protein, heparinase superfamily	Heparinase II/III-like protein	NA	PF07940.14
2128	0.21842489909781507	0.023777909368870344	-0.22970050609991607	-0.06937470155941496	0.21330374840481803	-0.04946797899965635	0.07936994690327477	0.15870410050006048	0.05896382475435406	Energy production and conversion	Pentose-5-phosphate-3-epimerase (Rpe) (PDB:1H1Y)	Ribulose-phosphate 3 epimerase family	ribulose-phosphate 3-epimerase [EC:5.1.3.1]	PF00834.20
2129	0.1053179116853107	-0.02129014146994505	-0.3595763085708602	-0.011854455343940506	0.060445513502889237	-0.09061826822397387	-0.055503143157053784	0.23406206186512407	0.014281275112857665	NA	NA	NA	NA	NA
2132	0.07090353562199611	-0.026915782624724566	0.07156560241120424	0.007318346216980209	0.03737671500420168	-0.010162780820707457	-0.10762623744580266	-0.11867584709868542	0.07427060809749711	NA	NA	NA	NA	NA
2133	0.30380480686458766	-0.16006605768054502	-0.3952403669210185	-0.0811366199687755	0.23720759682602288	0.08928134761772924	-0.011862456701795641	0.030789527929339405	0.02863246320641816	Replication and repair	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase (Acs) (PDB:4B2O) (PUBMED:14638756)	Acetyl-coenzyme A synthetase N-terminus;AMP-binding enzyme;AMP-binding enzyme C-terminal domain	acetyl-CoA synthetase [EC:6.2.1.1]	PF16177.6;PF00501.29;PF13193.7
2137	0.09168700826581447	-0.1368080024532399	-0.03261372806823671	-0.12115049633723296	0.2024158446232759	0.20097685320502132	-0.16438187976548477	-0.054753815555041274	0.06481345175964728	Signal Transduction	tRNA A37 threonylcarbamoyltransferase TsaD (TsaD) (PDB:3ENO) (PUBMED:23072323;21285948;32385138)	Carbamoyltransferase N-terminus;tRNA N6-adenosine threonylcarbamoyltransferase	N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	PF02543.16;PF00814.26
2138	0.1947373182146452	0.026056165501203488	0.015059709973606793	-0.17794766463087122	0.22635502782400604	0.030673132477642768	-0.013618375627704992	0.0033167738199589023	0.11118367640228155	Energy production and conversion	Porphobilinogen deaminase (HemC) (PDB:1AH5)	Porphobilinogen deaminase, dipyromethane cofactor binding domain;Porphobilinogen deaminase, C-terminal domain	hydroxymethylbilane synthase [EC:2.5.1.61]	PF01379.21;PF03900.16
2139	0.3658105148785502	0.05899858631988008	0.31376960394034764	-0.2513224517913463	0.42767920755407146	0.14281764978040978	-0.0963062229399353	-0.26609189943774875	0.09211823529227942	Energy production and conversion	Uroporphyrinogen-III synthase (HemD) (PDB:1JR2)	Uroporphyrinogen-III synthase HemD	uroporphyrinogen-III synthase [EC:4.2.1.75]	PF02602.16
2140	0.382070714533101	0.14283989285199442	-0.31859708682941423	-0.07333284727978713	0.2774362637417822	0.039296807610998116	0.014984978225443512	0.12801513768292988	0.022739560970745355	Energy production and conversion	Small-conductance mechanosensitive channel (MscS) (PDB:2OAU)	Mechanosensitive ion channel	MscS family membrane protein	PF00924.19
2141	0.21114385676680825	0.025819476980223608	-0.43095093648728183	-5.685268692515016e-4	0.07505682858903054	-0.19145138074181778	0.12861754249397378	0.24078394203450681	0.012219877105121152	Inorganic ion transport and metabolism	Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family (Ycf19)	YGGT family	YggT family protein	PF02325.18
2142	0.19942156637443256	-0.01630409131853636	-0.35836497742729506	-0.09856779502647178	0.08399068713620211	-0.17888881409336865	0.06068303942633404	0.21230900237023545	0.037208579518394125	Energy production and conversion	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase (FolD) (PDB:1A4I)	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	PF00763.24;PF02882.20
2145	0.04357370258155648	0.08277781080043828	0.04114033244960649	-0.12409389405028731	0.09716632188952129	-0.0020528947824436285	-0.04359723958140906	0.06378455266211192	0.07681202718677951	Energy production and conversion	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold (MenH) (PDB:4MYS)	alpha/beta hydrolase fold;Alpha/beta hydrolase family;Serine aminopeptidase, S33	haloacetate dehalogenase [EC:3.8.1.3]	PF00561.21;PF12697.8;PF12146.9
2146	-0.10095758706295224	0.20663748207673907	-0.11541281353206417	0.0025042802615495015	-0.07035927341804497	0.04675741167060005	0.12182234803911994	0.15832310637062932	0.0928730485790833	Function Unknown	Taurine dioxygenase, alpha-ketoglutarate-dependent (TauD) (PDB:1DRT)	Taurine catabolism dioxygenase TauD, TfdA family	NA	PF02668.17
2147	0.30900877540102445	0.11915256113137383	-0.3671625153890506	-0.07823486746385243	0.14425672981257168	0.07711296124599662	0.16417911134787408	0.11993555471969068	0.06181951974233061	NA	NA	Membrane transport protein	NA	PF03547.19
2148	-0.15281979303909507	0.05494081625711606	-0.14192632232766889	0.26316507117518595	-0.2104336929831636	-0.03692280141951049	0.00827448864313471	0.23003301196083334	0.07806462699136903	Energy production and conversion	L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily (UlaG) (PDB:2WYM)	Beta-lactamase superfamily domain;Beta-lactamase superfamily domain	N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D [EC:3.1.4.54]	PF12706.8;PF13483.7
2149	-0.2544540952370799	0.059261301944641104	-0.11387318701404436	-0.028025358772839546	-0.3468274373088879	0.10456808319038968	-0.07175644881136489	0.13596968598945658	0.12307278119741007	Energy production and conversion	Glucose/arabinose dehydrogenase, beta-propeller fold (YliI) (PDB:1C9U)	Glucose / Sorbosone dehydrogenase	aldose sugar dehydrogenase [EC:1.1.5.-]	PF07995.12
2150	0.2736756010347383	0.1042632178588087	-0.31758886268650255	-0.12134207236860714	0.13956259086556327	0.06848973136977618	0.049749004254065865	0.16424058824382787	0.0640047327746935	Replication and repair	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family (FabG) (PDB:6L1H)	short chain dehydrogenase;Enoyl-(Acyl carrier protein) reductase;KR domain;Polysaccharide biosynthesis protein	NA	PF00106.26;PF13561.7;PF08659.11;PF02719.16
2151	0.30528279625246596	0.036552849758536586	-0.14329782466076443	-0.19257813124176212	0.2733535035894903	0.012954893094682084	-0.09330717463209302	0.09476600991321749	0.05761852116410787	Carbohydrate metabolism and transport	Uncharacterized conserved protein related to deoxyribodipyrimidine photolyase (PDB:3ZXS)	Deoxyribodipyrimidine photo-lyase-related protein;FAD binding domain of DNA photolyase	deoxyribodipyrimidine photolyase-related protein	PF04244.14;PF03441.15
2153	0.3645103798894421	0.04416029802152171	-0.04155303341084605	-0.22816101076392079	0.34220968291834586	0.05946354752718274	-0.014708254989299212	-0.06126346577240317	0.059129643724325	Cell motility	GMP synthase, glutamine amidotransferase domain (GuaA1) (PDB:4WIM)	Glutamine amidotransferase class-I;Peptidase C26	GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	PF00117.29;PF07722.14
2155	-0.15534148498431308	-0.266789719787793	-0.27936963588883645	0.29001570793790815	-0.2656602349567745	-0.11704058807441783	0.252154772016234	0.03111060910354907	0.13012592635130496	General Functional Prediction only	Deoxyribodipyrimidine photolyase (PhrB) (PDB:1TEZ)	FAD binding domain of DNA photolyase	NA	PF03441.15
2157	-0.2340536652087279	0.08722285082179022	-0.23477963332844273	0.15846002359502506	-0.20121732640315387	-0.017458749488768018	-0.04331350154751685	0.2604226140778699	0.033090509090018094	NA	NA	NA	NA	NA
2158	0.007456919509677561	0.13804705736133668	-0.5050742839955272	0.036126348595797254	-0.10674291188429583	-0.09336278031133559	0.16712612996785753	0.32023165593064773	0.03829441884996922	RNA processing and modification	Argininosuccinate synthase (ArgG) (PDB:1J1Z)	Arginosuccinate synthase	argininosuccinate synthase [EC:6.3.4.5]	PF00764.20
2159	0.2012387143034483	-0.05209112848224903	-0.40792531014478106	-0.13110229481328425	0.16815571856027028	0.0252779458896765	-0.00890950266922026	0.22436842948313043	0.058522199759759704	Carbohydrate metabolism and transport	Invasion protein IalB, involved in pathogenesis (IalB) (PDB:3DTD)	NA	NA	NA
2160	-0.16997425942841413	0.0584360932820728	0.215454744841209	0.12991644341574599	-0.08996815022124251	0.03653209930542246	0.09877923843440119	-0.03316381692181532	0.05455204816860702	Energy production and conversion	Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family (PdxI) (PDB:1LQA) (PUBMED:32253339)	Aldo/keto reductase family	1-deoxyxylulose-5-phosphate synthase [EC:1.1.-.-]	PF00248.22
2161	0.27773002745119774	0.16393228132910465	-0.37722701553834576	-0.012636834568540081	0.14909198862776668	0.0399775695725739	0.11235517166297342	0.17622904751015206	0.03282143595125737	Lipid metabolism	Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family (YbhL) (PDB:4PGR) (PUBMED:28064000)	Inhibitor of apoptosis-promoting Bax1	uncharacterized protein	PF01027.21
2162	0.015559800539894628	0.16300244075265394	-0.2836740318009304	0.02503305861331182	-0.10212626009718388	-0.10262904208540316	-0.046158882533174905	0.2634845656360751	0.0515062521412323	NA	NA	Protein of unknown function (DUF2794)	NA	PF10984.9
2163	0.39503497202241356	0.1251370692558612	-0.21436851661331005	-0.242607465084966	0.3315005191392125	0.04133502399650413	0.030253616905546562	0.0649129813555425	0.061861584473689	Energy production and conversion	Intracellular septation protein A (YciB)	Intracellular septation protein A	intracellular septation protein	PF04279.16
2164	-0.0024088819823819027	0.10744300811289566	-0.07312059818562863	0.008616807114935282	-0.08296728672499176	0.04466826176691616	0.11878801276975685	0.07527971242625446	0.01923451446484046	Inorganic ion transport and metabolism	Heat shock protein HspQ (HspQ) (PDB:5YCQ)	Hemimethylated DNA-binding protein YccV like	heat shock protein HspQ	PF08755.12
2165	0.32978845291782516	0.17615055786093486	-0.19832878861341363	-0.09727547307608134	0.24009203805357895	0.07858628528810434	0.010129231474354837	0.09617001114573528	0.035909736151969816	Inorganic ion transport and metabolism	ABC-type transport system involved in cytochrome c biogenesis, permease component (CcmC)	Cytochrome C assembly protein	heme exporter protein C	PF01578.21
2166	0.20149003769940727	0.1529885842109932	-0.11799525554926449	-0.12088207180904342	0.2158460039754042	0.011476469110247385	-0.014265622784818388	0.1224480990067576	0.14626479510757734	NA	NA	NA	heme exporter protein D	NA
2167	0.4513873833872652	0.11272743847316019	0.13049297770640328	-0.05959371548885562	0.3459938075839304	0.1998043877961894	0.05444229420864972	-0.24750164722165063	0.10012359876758949	Amino Acid metabolis and transport	Cytochrome c biogenesis protein CcmE (CcmE) (PDB:1J6Q)	CcmE	cytochrome c-type biogenesis protein CcmE	PF03100.16
2168	-0.40701206155606456	-0.14368708508971795	0.3577582374378628	0.07143958342778975	-0.24685496924663614	0.06261717449417466	-0.06110260286008192	-0.11556350420824793	0.08105015968437873	Amino Acid metabolis and transport	Cytochrome c biogenesis protein CcmF (CcmF)	Cytochrome c-type biogenesis protein CcmF C-terminal;Cytochrome C assembly protein	cytochrome c-type biogenesis protein CcmF	PF16327.6;PF01578.21
2169	0.3542978841351108	5.719491061243221e-4	-0.15010617968672357	-0.2763623176666678	0.34312018099055613	0.0830824316195834	0.06470567934012487	0.035053018992285426	0.17469662665746666	Inorganic ion transport and metabolism	Thiol-disulfide isomerase or thioredoxin (TrxA) (PDB:1XFL)	Redoxin;Thioredoxin	cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE	PF08534.11;PF00085.21
2181	0.3401727230664369	-0.0036556205123667636	-0.4839329491775091	-0.09982828148809672	0.2315124090918679	-0.07108960874313582	-0.0060108643417994346	0.2612173414913041	0.03527443373902144	Energy production and conversion	ABC-type glycerol-3-phosphate transport system, periplasmic component (UgpB) (PDB:2Z8D)	Bacterial extracellular solute-binding protein;Bacterial extracellular solute-binding protein	multiple sugar transport system substrate-binding protein	PF01547.26;PF13416.7
2186	-0.21993545741855847	0.058907887475649984	0.37112887924332477	0.12448840986228503	-0.16704685388813317	-0.04760861938375828	0.05533554880538463	-0.11399204953716259	0.05039970712045311	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component (FcbT1) (PDB:2HZK)	Bacterial extracellular solute-binding protein, family 7	TRAP-type transport system periplasmic protein	PF03480.14
2191	-0.23670008119843164	-0.003625764373413714	-0.547334613876555	0.22868465740175334	-0.39157529587309126	-0.15575092477470134	0.14480731004136393	0.3313639794037965	0.027213303213473587	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component (FcbT1) (PDB:2HZK)	Bacterial extracellular solute-binding protein, family 7	TRAP-type transport system periplasmic protein	PF03480.14
2192	-0.2096406139204914	0.026600485260973004	-0.21692094101667686	0.1343841094489665	-0.31012522497052225	-0.005114327241836658	0.09481980361215918	0.14990940094299435	0.05653675426463194	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, small permease component (FcbT2)	Tripartite ATP-independent periplasmic transporters, DctQ component	NA	PF04290.13
2193	-0.11897686287548917	-0.01613365174856202	-0.016861730936669747	0.009800860551841508	0.05199924736606144	-0.18438667908073905	-0.061880721813376685	0.1798936191948615	0.03993880886739144	Function Unknown	TRAP-type mannitol/chloroaromatic compound transport system, large permease component (FcbT3)	Tripartite ATP-independent periplasmic transporter, DctM component	C4-dicarboxylate transporter, DctM subunit	PF06808.13
2194	-0.14132416196913355	0.012787649708365245	-0.5136822438619721	0.10610968571792696	-0.14467050402601161	-0.18730081452091105	0.06931255293978915	0.4134715403423077	0.06254723222591997	Energy production and conversion	Predicted arabinose efflux permease AraJ, MFS family (AraJ) (PDB:4LDS)	Major Facilitator Superfamily	NA	PF07690.17
2195	0.2383179488966225	0.12677229600865572	-0.408682444581394	0.042214585842743936	0.10787889952587446	0.14337788324835704	0.04712002208055574	0.16136554337931291	0.08180349828648521	Function Unknown	Fermentation-respiration switch esterase FrsA, DUF1100 family (FrsA)	Phospholipase/Carboxylesterase;Serine aminopeptidase, S33;Prolyl oligopeptidase family	NA	PF02230.17;PF12146.9;PF00326.22
2196	0.3697942526062189	-0.28657745073378726	-0.3503621643718781	-0.08780948403582658	0.22867759854271397	0.026037320394851977	0.14922980502512004	-0.029758751539970617	0.09321489255972476	NA	NA	NA	NA	NA
2197	-0.035454090746229606	0.13219608528909524	0.09054241910159483	0.05584535813065021	0.00996935294218057	-0.1183292335234083	0.18815069566427917	-0.04314266913245448	0.03202720048499504	Lipid metabolism	Signal recognition particle GTPase FtsY (FtsY) (PDB:4AK9)	Uncharacterized conserved protein (DUF2075);SRP54-type protein, GTPase domain;SRP54-type protein, helical bundle domain	fused signal recognition particle receptor	PF09848.10;PF00448.23;PF02881.20
2198	0.3573696605732213	0.04447934520305045	-0.01622765646617035	-0.1912548226296335	0.3453333623082269	0.01733753766377709	0.03431923948336277	-0.07970246818245445	0.09825786965040031	RNA processing and modification	Diaminopimelate epimerase (DapF) (PDB:1BWZ)	Diaminopimelate epimerase	diaminopimelate epimerase [EC:5.1.1.7]	PF01678.20
2199	-0.42953107325449424	0.03254454536251577	-0.03774187121542673	0.4072895589795232	-0.3976405619219896	-0.19114901050788582	0.22054814144664198	0.10417311722841455	0.027783430342090513	Lipid metabolism	Signal recognition particle GTPase (Ffh) (PDB:2V3C)	CobQ/CobB/MinD/ParA nucleotide binding domain;SRP54-type protein, GTPase domain;SRP54-type protein, helical bundle domain;Signal peptide binding domain	signal recognition particle subunit SRP54 [EC:3.6.5.4]	PF01656.24;PF00448.23;PF02881.20;PF02978.20
2200	-0.5058793108434109	0.01273010219814808	0.12175520557849512	0.2126604251695494	-0.4758841243405121	-0.0953311379117114	0.025693107933037522	0.08477067872076928	0.10732206100641739	Signal Transduction	Ribosomal protein S16 (RpsP) (PDB:4V4H)	Ribosomal protein S16	small subunit ribosomal protein S16	PF00886.20
2201	0.1097001333078521	0.11355282611570995	-0.5459149109367996	0.015075936406345613	-0.028988094088427705	-0.00992392014339157	-0.024091770869864738	0.2916031645352097	0.06279968877122655	Signal Transduction	tRNA G37 N-methylase TrmD (TrmD) (PDB:1P9P)	tRNA (Guanine-1)-methyltransferase	tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	PF01746.22
2202	-0.08297554573485824	0.026001654975114516	-0.2342152723200378	0.05632831156536342	-0.20552853367206075	0.04902533140473325	0.19022620805107904	0.09007315462184567	0.08113971614841013	Signal Transduction	Ribosomal protein L19 (RplS) (PDB:1VS6) (PUBMED:27941785)	Ribosomal protein L19	large subunit ribosomal protein L19	PF01245.21
2205	-0.12375340217050054	-1.4458282402554507e-4	-0.03543264327545322	0.018315690120746856	-0.08826875255970872	-0.1939033361966839	0.07057274171058305	0.028535987405649145	0.025424670617587516	Amino Acid metabolis and transport	Isocitrate/isopropylmalate dehydrogenase (LeuB) (PDB:1GC9)	Isocitrate/isopropylmalate dehydrogenase	3-isopropylmalate dehydrogenase [EC:1.1.1.85]	PF00180.21
2206	0.03743457332276984	0.003160330581365185	-0.14375617029409749	0.006693571185950541	0.0069986105144400875	-0.06252244075079491	-0.07190392390601426	0.13757962147163014	0.03892872184831975	Replication and repair	Acyl-CoA dehydrogenase related to the alkylation response protein AidB (CaiA) (PDB:1BUC)	Acyl-CoA dehydrogenase, C-terminal domain;Acyl-CoA dehydrogenase, C-terminal domain;Acetyl-CoA dehydrogenase C-terminal like;Acyl-CoA dehydrogenase, middle domain;Acyl-CoA dehydrogenase, N-terminal domain	3-(methylthio)propanoyl-CoA dehydrogenase [EC:1.3.8.-]	PF00441.25;PF08028.12;PF12806.8;PF02770.20;PF02771.17
2207	-0.02755946443027344	-0.010236168760081142	-0.15566423770331111	0.11467654039734793	-0.0876354613829588	-0.21447799931825376	0.09780746518276107	0.1384831571901959	0.03807637980283641	Replication and repair	O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) (MenE/FadK) (PDB:5EY9) (PUBMED:25151136;27455459)	AMP-binding enzyme;AMP-binding enzyme C-terminal domain	fatty-acyl-CoA synthase [EC:6.2.1.-]	PF00501.29;PF13193.7
2211	-0.332873796883348	0.027745837634084735	0.0060193513176816866	0.2297882048508012	-0.3539068460486157	-0.14876379173045656	0.05978681422187176	0.11528977503266359	0.1042536304431869	Amino Acid metabolis and transport	Succinate dehydrogenase/fumarate reductase, cytochrome b subunit (SdhC) (PDB:2WU2) (PUBMED:18511537)	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	succinate dehydrogenase / fumarate reductase, cytochrome b subunit	PF01127.23
2213	-0.1899061380209611	-0.03129743867787481	-0.38697008057406734	0.2782227223395872	-0.32808998849125404	-0.15732403149375646	0.3505564052820255	0.16340247638631164	0.028166132341914733	Amino Acid metabolis and transport	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit (SdhA) (PDB:1KF6)	FAD binding domain;Fumarate reductase flavoprotein C-term	succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	PF00890.25;PF02910.21
2214	0.39808760264745385	0.10086468649296891	-0.2859792605157624	-0.1571008799691971	0.3398520961223369	0.04548988702299814	0.07300944955695927	0.12730139298629348	0.032667164770853255	Amino Acid metabolis and transport	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit (SdhB/FrdB) (PDB:6LUM)	2Fe-2S iron-sulfur cluster binding domain;4Fe-4S dicluster domain;4Fe-4S dicluster domain;4Fe-4S dicluster domain	succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4]	PF13085.7;PF13237.7;PF13534.7;PF13183.7
2215	0.06422626748876509	0.018216434076368363	-0.2538407360827143	0.16778715857386717	0.08671806424000897	-0.028148341156941703	0.1933683512474278	0.15983770482743662	0.02961013058250969	Replication and repair	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase (AdhE) (PDB:1A4S)	Aldehyde dehydrogenase family	malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]	PF00171.23
2216	0.35945051612096945	0.1937023346900302	-0.08005178440665868	-0.23221987388177798	0.3238847078333735	0.25220144067621525	0.07555867172662517	0.004354421933293989	0.04991869113312822	Amino Acid metabolis and transport	Malate/lactate dehydrogenase (Mdh) (PDB:4WLO)	lactate/malate dehydrogenase, alpha/beta C-terminal domain;lactate/malate dehydrogenase, NAD binding domain	malate dehydrogenase [EC:1.1.1.37]	PF02866.19;PF00056.24
2217	-0.1380414532233298	-0.06184750109570063	0.2586380013323629	0.04715616833742701	0.029801502072159924	-0.025714515815027646	-0.1455189744095236	-0.05538918617163916	0.07103356554208233	Amino Acid metabolis and transport	Succinyl-CoA synthetase, beta subunit (SucC) (PDB:1SCU)	ATP-grasp domain;ATP-grasp domain;CoA-ligase	succinyl-CoA synthetase beta subunit [EC:6.2.1.5]	PF08442.11;PF13549.7;PF00549.20
2218	0.23573176453681233	-0.1310689808225166	-0.27931424196877924	0.11986944217171287	0.13363558536873715	0.1450242695158081	0.32552317776635653	-0.042739047142711095	0.058829743352301136	Amino Acid metabolis and transport	Succinyl-CoA synthetase, alpha subunit (SucD) (PDB:1CQI)	CoA binding domain;CoA-ligase;Succinyl-CoA ligase like flavodoxin domain	succinyl-CoA synthetase alpha subunit [EC:6.2.1.5]	PF02629.20;PF00549.20;PF13607.7
2219	0.2510621128701611	-0.0991153672010404	-0.2181916625980295	0.04587485744313561	0.23089175014244695	0.039429711935776574	0.17067822173824954	0.04677053776010459	0.03961738880656031	Amino Acid metabolis and transport	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes (SucA) (PDB:2JGD)	2-oxoglutarate dehydrogenase N-terminus;Dehydrogenase E1 component;2-oxoglutarate dehydrogenase C-terminal;Transketolase, pyrimidine binding domain	2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]	PF16078.6;PF00676.21;PF16870.6;PF02779.25
2220	0.4764081848125098	-0.14594704067830253	0.22056894604129093	-0.2632491312031265	0.45338436033034507	0.3086128391486714	-0.007268024032484175	-0.38437516145701	0.07264066595567034	Amino Acid metabolis and transport	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component (AceF) (PDB:1B5S)	2-oxoacid dehydrogenases acyltransferase (catalytic domain);Biotin-requiring enzyme;e3 binding domain	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]	PF00198.24;PF00364.23;PF02817.18
2221	0.27800905115053826	0.06036981209380789	-0.21802448929298285	-0.23792977565443665	0.24662597482973558	0.0608683904781144	0.055674680732649154	0.06417288979284407	0.0449098509085659	Amino Acid metabolis and transport	Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase (Lpd) (PDB:6QKG)	FAD binding domain;FAD binding domain;FAD dependent oxidoreductase;Glucose inhibited division protein A;HI0933-like protein;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	dihydrolipoamide dehydrogenase [EC:1.8.1.4]	PF00890.25;PF01494.20;PF12831.8;PF01134.23;PF03486.15;PF13450.7;PF00070.28;PF07992.15;PF13738.7;PF02852.23
2225	0.0794154576821293	0.10287635577289948	-0.037412731007767534	-0.10292297662629381	0.038347005835100284	-0.0351680819543012	0.021633802405488324	0.08146710327762341	0.05808029334162272	General Functional Prediction only	Primosomal protein N' (replication factor Y) - superfamily II helicase (PriA) (PDB:6DCR)	DEAD/DEAH box helicase;Helicase conserved C-terminal domain;3'DNA-binding domain (3'BD);Primosomal protein N C-terminal domain;PriA DNA helicase Cys-rich region (CRR) domain;Type III restriction enzyme, res subunit	primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	PF00270.30;PF00271.32;PF17764.2;PF18074.2;PF18319.2;PF04851.16
2230	0.1290144790234882	0.11550917380060333	-0.14858857901275824	-0.11159668953138623	0.1411891547416812	-0.04331473256860289	0.0428945520991398	0.16601075318966824	0.036196759323233796	Amino Acid metabolis and transport	FoF1-type ATP synthase, epsilon subunit (AtpC) (PDB:3OAA) (PUBMED:29149348;30304218)	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	F-type H+-transporting ATPase subunit epsilon	PF02823.17
2231	0.3335045405136685	0.1333109195656224	-0.2633322993648017	-0.15326554007809945	0.26336494220778395	0.06868311311059828	0.06718601550950533	0.06698307686135727	0.07051022343292777	Cell cycle control and mitosis	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family (MutT) (PDB:4V14)	NUDIX domain	putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]	PF00293.29
2232	-0.06440690707045808	0.016103664349136758	-0.25834579272147523	-0.026672732304951888	-0.06038584294703523	0.015758529927346682	0.03533134083735055	0.22858297546507417	0.06032251693873809	Inorganic ion transport and metabolism	C-terminal processing protease CtpA/Prc, contains a PDZ domain (CtpA) (PDB:6IQU)	PDZ domain;PDZ domain;PDZ domain;Peptidase family S41	carboxyl-terminal processing protease [EC:3.4.21.102]	PF00595.25;PF13180.7;PF17820.2;PF03572.19
2233	0.09689766528013719	0.15012062008576563	-0.06265240324159141	-0.05194872117613699	0.08187103831183386	-0.015460000484574337	0.15108410142207995	0.05613399131827528	0.03129116741426719	Signal Transduction	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits (RsfS) (PDB:6SJ6)	Ribosomal silencing factor during starvation	ribosome-associated protein	PF02410.16
2234	-0.39737565656772444	-0.1262047451265991	0.4594533634139741	0.11409085344836407	-0.24083438621891942	0.02313021073953494	-0.14720728831075264	-0.15593601608970123	0.14258722116207007	Energy production and conversion	Nicotinate-nucleotide adenylyltransferase NadD (NadD) (PDB:1YUM)	Cytidylyltransferase-like	nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	PF01467.27
2235	-0.34671651776234946	0.08783931958001853	0.21343844526893405	0.022275860765708033	-0.18878926054200673	0.030797244946396532	-0.054538904610276086	0.0175772183329093	0.1011376569576632	RNA processing and modification	Gamma-glutamyl phosphate reductase (ProA) (PDB:4GHK)	Aldehyde dehydrogenase family	glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	PF00171.23
2236	-0.23583100412225672	-0.0197548853768453	0.3365821574882802	-0.005987531074724486	-0.04492995043142606	-0.15863689583127186	-0.21289347510536225	0.0353536487230773	0.061463285298319716	RNA processing and modification	Glutamate 5-kinase (ProB) (PDB:2W21)	Amino acid kinase family;PUA domain	glutamate 5-kinase [EC:2.7.2.11]	PF00696.29;PF01472.21
2237	0.016536873086693795	-0.055320258805843514	-0.3262852596943384	0.026129840361399672	0.002479207163180189	-0.24857829488714014	0.03879842364477893	0.27990123772545866	0.05587555626843467	Energy production and conversion	GTPase involved in cell partioning and DNA repair (Obg) (PDB:1LNZ)	Ferrous iron transport protein B;GTP1/OBG;50S ribosome-binding GTPase	GTPase [EC:3.6.5.-]	PF02421.19;PF01018.23;PF01926.24
2240	0.169565538190515	-0.026921688273198824	-0.1162581069814532	-0.08753928818387041	0.19983697710200024	-0.11478090620301781	-5.838826336108578e-4	0.07352929580930953	0.09805153756671076	Carbohydrate metabolism and transport	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II (GloB) (PDB:1QH3) (PUBMED:25670698)	Hydroxyacylglutathione hydrolase C-terminus;Metallo-beta-lactamase superfamily	hydroxyacylglutathione hydrolase [EC:3.1.2.6]	PF16123.6;PF00753.28
2242	0.5690203694283595	0.043876992424106545	-0.07443848190057971	-0.2890933958426353	0.5661402361559265	0.21685169632365525	-0.02379903315004256	-0.10681702234129221	0.05980483860090274	RNA processing and modification	Homoserine O-acetyltransferase (MET2) (PDB:2VAT)	alpha/beta hydrolase fold	homoserine O-acetyltransferase/O-succinyltransferase [EC:2.3.1.31 2.3.1.46]	PF00561.21
2243	-0.15092512529261418	0.04617225246239048	0.41484419448244986	0.10731938701262343	0.02163638579493507	-0.007469838113810933	-0.15136605510417755	-0.11343097428437739	0.1014855352457769	RNA processing and modification	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase (HisC) (PDB:4R2N)	Aminotransferase class I and II;Aminotransferase class-V;Cys/Met metabolism PLP-dependent enzyme;DegT/DnrJ/EryC1/StrS aminotransferase family	histidinol-phosphate aminotransferase [EC:2.6.1.9]	PF00155.22;PF00266.20;PF01053.21;PF01041.18
2245	-0.27614203588820296	-0.1878381815056724	0.1723726802692565	0.07464798903956009	-0.25813798112324465	-0.07819115871909	-0.11101447412890318	-0.021627146058875876	0.25610647044715273	Energy production and conversion	Cell wall-associated hydrolase, NlpC_P60 family (NlpC) (PDB:2EVR)	NlpC/P60 family;Bacterial dipeptidyl-peptidase Sh3 domain;Bacterial SH3 domain	gamma-D-glutamyl-L-lysine dipeptidyl-peptidase [EC:3.4.14.13]	PF00877.20;PF18348.2;PF08239.12
2246	0.36443625641865207	0.03716044826100388	-0.26722311136272414	-0.2154224986201937	0.31690166284069565	0.07861057200730008	-0.05845059749854733	0.16151602476809487	0.044497547935602615	Energy production and conversion	Predicted arabinose efflux permease AraJ, MFS family (AraJ) (PDB:4LDS)	Major Facilitator Superfamily	MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG	PF07690.17
2247	0.027971932207377526	-0.06948216728888329	-0.12038207378104608	-0.0020124258298507415	0.03199179486385252	-0.0835543077493617	0.0647147129572317	0.12492150216298051	0.059445470464129874	Lipid metabolism	Trk-type K+ transport system, membrane component (TrkG) (PDB:3PJZ)	Cation transport protein	trk system potassium uptake protein	PF02386.17
2248	0.287078190516013	0.10670914347561226	-0.1152169373477612	-0.127293122760157	0.24813379588707193	0.008960663479177518	0.05388290026132484	0.03775520596487784	0.04118236445660897	Signal Transduction	Lysyl-tRNA synthetase, class I (LysS) (PDB:1IRX)	tRNA synthetases class I (W and Y);tRNA synthetases class I (K)	lysyl-tRNA synthetase, class I [EC:6.1.1.6]	PF00579.26;PF01921.19
2249	0.25936880569889625	0.09369357246470758	0.009762303043964908	-0.11482334241596316	0.27070978886040503	0.07899083668748427	0.11272711437645169	-0.0653063823133397	0.07174142889083966	Cell motility	Dihydroorotate dehydrogenase (PyrD) (PDB:1GT8)	Dihydroorotate dehydrogenase	dihydroorotate dehydrogenase [EC:1.3.5.2]	PF01180.22
2250	0.11554331650889685	0.08601161572287104	-0.37494856079342587	-0.09801226077469384	0.1099626014076056	-0.05956864955932652	-0.007675963618828802	0.25212121701637524	0.018939203743255913	Signal Transduction	Ribosomal protein L28 (RpmB) (PDB:2JZ6)	Ribosomal L28 family	large subunit ribosomal protein L28	PF00830.20
2251	0.016261404660745105	0.004794125548107057	-0.35094722350160806	-0.07332780492241825	0.09875524042138137	-0.12282462937141982	-0.058388540704119654	0.2644878743224001	0.0479392723086329	Signal Transduction	Queuosine precursor transporter YhhQ, DUF165 family (YhhQ) (PUBMED:31481610)	Putative vitamin uptake transporter	queuosine precursor transporter	PF02592.16
2252	0.2883963816951055	0.006932040055971956	-0.13508732024372322	-0.1586710231147869	0.3028586513088352	-0.06511996361777059	-0.00280762132110787	0.062122294591823946	0.028355212215440344	RNA processing and modification	Arginase/agmatinase family enzyme (SpeB) (PDB:1CEV)	Arginase family	agmatinase [EC:3.5.3.11]	PF00491.22
2253	0.37900476321078336	0.028676692705615243	-0.35044999111726854	-0.10256742420786333	0.24577505921483106	0.004890635444930389	0.1945608724191225	0.08798397780252301	0.03859459776782355	Inorganic ion transport and metabolism	Deoxyhypusine synthase (DYS1) (PDB:1DHS)	Deoxyhypusine synthase	deoxyhypusine synthase [EC:2.5.1.46]	PF01916.18
2254	0.26831341261946307	0.04648272094886468	-0.060400632981056614	-0.15609747819482966	0.2604321110846503	0.04349585925175693	0.11594802551282335	-0.03108339184379978	0.059654773735767316	RNA processing and modification	Diaminopimelate decarboxylase (LysA) (PDB:1D7K)	Pyridoxal-dependent decarboxylase, pyridoxal binding domain;Pyridoxal-dependent decarboxylase, C-terminal sheet domain	ornithine decarboxylase [EC:4.1.1.17]	PF02784.17;PF00278.23
2255	0.33171267605540955	0.02315413822515554	-0.3679054131368501	0.1578487485202958	0.2223402975312469	0.004755865223871636	0.31703135708385216	0.08234738158050632	0.022692170551352035	Function Unknown	DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains (PDB:3RQI)	Response regulator receiver domain	two-component system, response regulator RegA	PF00072.25
2256	0.2594048238806987	0.11084428680261135	-0.2711397210276925	-0.07978604193511879	0.17292361328212916	-0.028856427879171247	0.09891683527275308	0.1217519410321501	0.08156524949977324	Energy production and conversion	Biotin transporter BioY (BioY) (PDB:4DVE)	BioY family	biotin transport system substrate-specific component	PF02632.15
2257	0.12478479654915829	0.1429956381044053	-0.2049882662296602	-0.057919531338237885	0.08943688956777861	0.026716324549849492	-0.008604418634821073	0.16402022530985982	0.04049617721003544	General Functional Prediction only	5'-3' exonuclease Xni/ExoIX (flap endonuclease) (ExoIX) (PDB:3ZDA) (PUBMED:19000038;23821668)!!!DNA polymerase I, 3'-5' exonuclease and polymerase domains (PolA) (PDB:1D8Y)	5'-3' exonuclease, C-terminal SAM fold;5'-3' exonuclease, N-terminal resolvase-like domain;DNA polymerase family A;3'-5' exonuclease	DNA polymerase I [EC:2.7.7.7]	PF01367.21;PF02739.17;PF00476.21;PF01612.21
2258	0.049511980218533855	0.008124345564925951	-0.38097337297088774	0.13653810412328063	0.012804694152602988	-0.15995582534121983	0.2567935417366493	0.22636556680790132	0.007947323916086393	Function Unknown	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain (OmpR) (PDB:1XHF)	Response regulator receiver domain;Transcriptional regulatory protein, C terminal	two-component system, OmpR family, response regulator ChvI	PF00072.25;PF00486.29
2259	-0.019030312089329895	0.032387450384692665	0.15011031707519099	0.1515699018538562	-0.08567266307870669	-0.0961039675222849	-0.015542784143600639	-0.1141316391375856	0.07295174330056722	Function Unknown	Signal transduction histidine kinase (BaeS) (PDB:1JOY)	HAMP domain;Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase;His Kinase A (phospho-acceptor) domain	two-component system, OmpR family, sensor histidine kinase ChvG [EC:2.7.13.3]	PF00672.26;PF02518.27;PF00512.26
2260	0.2153102853283865	0.04230845515940039	-0.2188698267516847	-0.00828943752892098	0.1729107339719031	-0.035057561775648755	0.08952008930183426	0.07044778128272165	0.020486646770533398	Energy production and conversion	S-adenosylhomocysteine hydrolase (SAM1) (PDB:1A7A)	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain;S-adenosyl-L-homocysteine hydrolase;S-adenosyl-L-homocysteine hydrolase, NAD binding domain;Acetohydroxy acid isomeroreductase, NADPH-binding domain;Putative NAD(P)-binding	adenosylhomocysteinase [EC:3.3.1.1]	PF02826.20;PF05221.18;PF00670.22;PF07991.13;PF13241.7
2261	0.13897279079589148	0.10124503919791494	-0.03822893023539048	0.11126471269513731	-0.031124816250123213	-0.11987850959854246	-0.06581057130769304	0.0806004675643268	0.1482745742118886	Signal Transduction	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE (TsaE) (PDB:1FL9)!!!Predicted phosphotransferase, aminoglycoside/choline kinase (APH/ChoK) family	Threonylcarbamoyl adenosine biosynthesis protein TsaE	tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	PF02367.18
2262	-0.011448422116581094	-0.07899986435060576	0.06355373975960657	0.04002975325810703	0.18139080768658958	-0.05037543806235118	-0.10383176651281238	0.026817408202950203	0.19607926155521346	Carbohydrate metabolism and transport	Predicted phosphotransferase, aminoglycoside/choline kinase (APH/ChoK) family	Phosphotransferase enzyme family	N-acetylmuramate 1-kinase [EC:2.7.1.221]	PF01636.24
2263	0.4508475970964676	-0.03975666253407742	-0.08388082263204226	-0.22399102786044947	0.433044934772788	0.10800509374928088	-0.02378319495555434	-0.13063675905674496	0.15534790143384306	Signal Transduction	NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis protein s (GCD1) (PDB:6JQ8)	Nucleotidyl transferase;MobA-like NTP transferase domain	N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase [EC:2.7.7.99]	PF00483.24;PF12804.8
2264	0.18412850513599818	0.0873833909746274	-0.004574814431934377	0.06395694971692882	0.09842352322414526	0.06785264389552231	0.06550263013844901	0.0010684694479641487	0.12952862325311434	Energy production and conversion	Phosphoglycerate mutase (BPG-dependent) (GpmA) (PDB:1E58)	Histidine phosphatase superfamily (branch 1)	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	PF00300.23
2266	0.10534398975352105	-0.13011420834397183	0.11466422867535342	-0.060889868266251854	0.11551233164242349	0.07389949730343115	-0.24904412417139912	-0.0559969306906922	0.0806720104058596	Carbohydrate metabolism and transport	Predicted transglycosylase, contains SLT domain (SLT)	NA	NA	NA
2269	-0.23816037475711593	-0.14865698434741637	0.11296949382169699	0.09836610935092352	-0.24904788683903906	-0.005989979149500838	-0.12327485010347076	-0.0866235413439452	0.14160930660566404	Lipid metabolism	3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains (SseA) (PDB:1BOH)	Rhodanese-like domain	thiosulfate/3-mercaptopyruvate sulfurtransferase [EC:2.8.1.1 2.8.1.2]	PF00581.21
2270	0.33478830925193725	-0.05816187207007533	-0.27128468769365277	-0.2878549504190992	0.3518082483252603	0.05547768272540231	0.1170001176410616	0.04503850514557296	0.08224895240731407	Inorganic ion transport and metabolism	Peptide methionine sulfoxide reductase MsrA (MsrA) (PDB:1FF3)	Peptide methionine sulfoxide reductase	peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]	PF01625.22
2271	0.19305530310957833	0.0361355868538524	-0.18899128493283898	0.07993392587096128	0.14242282471283785	-0.11953539420640998	-0.013819706697826785	0.09443982531964812	0.039450219900799235	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	S-adenosylmethionine uptake transporter	PF00892.21
2272	0.09841048461745458	0.017002875568269737	-0.22467974076549316	-0.07037268556116619	0.1488084522328398	-0.11611116069076818	0.01987159553506745	0.16785709001302854	0.05470510592852308	General Functional Prediction only	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase (AlkA) (PDB:1DIZ)	HhH-GPD superfamily base excision DNA repair protein	DNA-3-methyladenine glycosylase II [EC:3.2.2.21]	PF00730.26
2274	-0.02405345469507887	0.09626649595369025	-0.10929705856428817	0.13100612848203297	-0.10204594688385149	-0.06990577825693066	0.03636024680416519	0.12531394672783353	0.04988915605620669	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF1330 family	Domain of unknown function (DUF1330)	NA	PF07045.12
2275	-0.3344864969139901	-0.019319433907342434	0.11459164715363342	0.3696623353066294	-0.3725273949407543	-0.09885959029943159	0.013746139550027776	0.028017088258385503	0.13902630868988647	Amino Acid metabolis and transport	Cytochrome c, mono- and diheme variants (CccA) (PDB:1A2S)	Cytochrome C oxidase, cbb3-type, subunit III;Cytochrome c	NA	PF13442.7;PF00034.22
2276	0.010089814159581318	0.08227596586104495	0.03203872004191336	0.00972337618036404	0.008042187143585445	-0.039913200885225264	-0.0662303042645948	0.05759233289767518	0.0538063487718744	Energy production and conversion	Peptidoglycan/xylan/chitin deacetylase, PgdA/NodB/CDA1 family (CDA1) (PDB:1NY1)	Polysaccharide deacetylase	allantoinase [EC:3.5.2.5]	PF01522.22
2277	0.4682343029648944	0.07476531808683662	-0.10626462493858098	-0.2746649089418685	0.4173720351087951	0.17424829715638485	0.0030594356435947696	-0.047318803474309	0.13328284335292429	Cell motility	Ureidoglycolate hydrolase (allantoin degradation) (AllA) (PDB:1XSQ)	Ureidoglycolate lyase	ureidoglycolate lyase [EC:4.3.2.3]	PF04115.13
2278	0.4038101551779753	0.08615322963943094	-0.4300788376064035	-0.12502509426450747	0.2920071471987415	-0.03201569855607628	0.061139441203680686	0.14028770487063383	0.0844740543941094	Cell motility	Allantoicase (Alc) (PDB:1O59)	Allantoicase repeat	allantoicase [EC:3.5.3.4]	PF03561.16
2280	-0.35337493440336565	0.03942270159811702	0.32469478913928346	0.12227834550764781	-0.22605306202460382	0.06545282843466375	-0.09917230129503084	-0.028928778328367273	0.12894198568063908	Cell motility	5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family (HiuH) (PDB:2IGL)	HIUase/Transthyretin family	5-hydroxyisourate hydrolase [EC:3.5.2.17]	PF00576.22
2283	-0.0013020762938289947	0.12758135414342545	-0.04202316112234684	0.11652089056731015	-0.061118739098650045	-0.010207898513701618	-0.04609757063785636	0.08309197429141452	0.06045761739841204	Signal Transduction	tRNA(Arg) A34 adenosine deaminase TadA (TadA) (PDB:2A8N)	Cytidine and deoxycytidylate deaminase zinc-binding region;MafB19-like deaminase	NA	PF00383.24;PF14437.7
2284	-0.05362220916826417	-0.05222387986314945	-0.3391268627761455	0.006616793922803912	0.011666672108366445	-0.005344471362207849	0.03232331741917624	0.2201667685829127	0.04455901325517379	Nucleotide metabolism and transport	Uncharacterized membrane protein	Urate oxidase N-terminal	NA	PF06181.12
2286	-0.09641379731114733	0.084885393240028445	-0.12341941747515846	0.10261250463269236	-0.18553486780690726	-0.13338593024060172	0.11876821669989035	0.08626668882538527	0.04450316419579737	Function Unknown	Lipoprotein Med, regulator of KinD/Spo0A, PBP1-ABC superfamily, includes NupN (Med) (PDB:2FQW) (PUBMED:21622736)	ABC transporter substrate-binding protein PnrA-like;Periplasmic binding protein	basic membrane protein A and related proteins	PF02608.15;PF13458.7
2287	0.12595968662525409	-0.04598721265200299	-0.2583045524361526	-0.0345886026980694	0.11141708907153766	-0.16661769803066415	0.04052685874137858	0.11472773685301108	0.03295593206503207	Cell motility	ABC-type guanosine uptake system NupNOPQ, permease subunit NupQ (NupQ) (PUBMED:21926227)	Branched-chain amino acid transport system / permease component	general nucleoside transport system permease protein	PF02653.17
2288	0.32069407633293195	0.11327072540521474	0.054840854766388315	-0.09631975776929738	0.3354045137640551	0.13698475856847986	0.0037799626093415885	-0.10321356558027332	0.026706122705342374	Cell motility	ABC-type guanosine uptake system NupNOPQ, permease component NupP (NupP) (PUBMED:21926227)	Branched-chain amino acid transport system / permease component	general nucleoside transport system permease protein	PF02653.17
2289	-0.15612737563749093	0.06205822186019315	-0.1268942683802355	0.07389031899740443	-0.1241968945248706	0.028255793928811914	0.01754187836092883	0.17585007857459672	0.04637696403020755	Cell motility	ABC-type guanosine uptake system NupNOPQ, ATPase component NupO (NupO) (PUBMED:21926227)	ABC transporter	general nucleoside transport system ATP-binding protein	PF00005.28
2290	-0.30952533738678917	0.06413019626542855	0.22600894700877777	0.1434786954771815	-0.300125372120264	-0.15068387378539835	-0.11825394688415561	-0.005988538326969555	0.14345682737050003	Signal Transduction	tRNA(Arg) A34 adenosine deaminase TadA (TadA) (PDB:2A8N)	Cytidine and deoxycytidylate deaminase zinc-binding region;MafB19-like deaminase	NA	PF00383.24;PF14437.7
2294	-0.1775305808912261	-0.0468309120508176	-0.23888846438890024	0.1710233253254516	-0.11913732930353828	-0.10974966058040221	0.29175343413644045	0.16221549465225996	0.06204612090486689	RNA processing and modification	Protease II (PtrB) (PDB:4BP9)	Prolyl oligopeptidase family;Prolyl oligopeptidase, N-terminal beta-propeller domain	oligopeptidase B [EC:3.4.21.83]	PF00326.22;PF02897.16
2295	0.2107304890181291	-0.03209112429720476	-0.23179152507098622	-0.0073400727850140264	0.1684853289460446	-0.05678814867965287	0.015343673694269845	0.08575540550733265	0.045339490043123015	NA	NA	NA	NA	NA
2296	0.39312690516767146	-0.4000632643999058	0.016096324077718438	-0.2813456026988369	0.39297690796985324	0.1538013213090124	-0.06734753069902978	-0.15941367098047518	0.15030004900860228	Energy production and conversion	ADP-heptose:LPS heptosyltransferase (RfaF) (PDB:1PSW)	Glycosyltransferase family 9 (heptosyltransferase)	NA	PF01075.18
2297	0.2717859785751733	0.05397735108628368	-0.0981420968773134	-0.2369521545839582	0.26587696543492767	0.0348124352223322	0.18081257335361192	-0.013688881438939187	0.08166157683827893	RNA processing and modification	4-hydroxy-tetrahydrodipicolinate synthase/N-acetylneuraminate lyase (DapA) (PDB:2R91) (PUBMED:27574185)	Dihydrodipicolinate synthetase family	NA	PF00701.23
2298	0.2333302377260506	0.0923112601608826	-0.23924070376115214	-0.08661528368218409	0.19258242942255424	-0.05376557697145215	0.12991246692011058	0.09743641306034859	0.039226364209350294	Replication and repair	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases (Cfa) (PDB:5Z9O)	Mycolic acid cyclopropane synthetase;Histone methylation protein DOT1;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Putative methyltransferase;Methionine biosynthesis protein MetW;Met-10+ like-protein;Methyltransferase small domain;Ribosomal protein L11 methyltransferase (PrmA);Ribosomal RNA adenine dimethylase;ubiE/COQ5 methyltransferase family	cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]	PF02353.21;PF08123.14;PF08241.13;PF08242.13;PF13489.7;PF13649.7;PF13847.7;PF02390.18;PF07021.13;PF02475.17;PF05175.15;PF06325.14;PF00398.21;PF01209.19
2299	0.14018083175329704	-0.06461139747056271	0.21565840720054044	-0.19763337873051423	0.16401579889498827	0.21621000008408608	-0.054278604670769566	-0.22042363557628142	0.09612984156471502	NA	NA	NA	NA	NA
2301	0.33219936975027003	0.011710737619136113	-0.09378308728117621	-0.3613886656587329	0.39585638793923456	0.04960043677140241	-0.03556025402653803	-0.06011260654141336	0.05660203951100735	Carbohydrate metabolism and transport	Predicted thiol-disulfide oxidoreductase YuxK, DCC family (YuxK) (PUBMED:15236740)	Protein of unknown function, DUF393	NA	PF04134.13
2302	0.171583145900253	-0.03589130480991662	0.02493638892668971	-0.17941631526574675	0.26828843320301143	-0.04030587049830735	-0.07935241617228196	0.025232942283722824	0.036342933363811634	Carbohydrate metabolism and transport	Zn-dependent protease PmbA/TldA or its inactivated homolog (TldD) (PDB:3TV9) (PUBMED:12029038)	Putative modulator of DNA gyrase	TldD protein	PF01523.17
2303	-0.32407194786800825	-0.04752939250708844	-0.058903384454542344	0.19151654505662144	-0.3564299853815711	-0.0029769229564508273	0.002422104901886483	0.12984813639959913	0.09725751631306598	Carbohydrate metabolism and transport	Zn-dependent protease PmbA/TldA or its inactivated homolog (TldD) (PDB:3TV9) (PUBMED:12029038)	Putative modulator of DNA gyrase	PmbA protein	PF01523.17
2304	-0.4369654677799967	-0.04381789343367098	0.26077741930551573	0.13316521110528537	-0.36289819699652437	-0.04826427533668087	-0.055191193934403776	0.004936532263387927	0.10538210458340194	Carbohydrate metabolism and transport	Predicted NAD/FAD-dependent oxidoreductase (PDB:4ZCC)	NAD(P)-binding Rossmann-like domain	renalase [EC:1.6.3.5]	PF13450.7
2305	0.3857466519964707	-0.10703681656564494	-0.3744272152654757	-0.1447621271964339	0.36315084453845864	-0.0156957348300392	0.05802543747912208	0.09677956940301102	0.13708516031735915	NA	NA	NA	NA	NA
2306	0.18054920031273508	-0.01618835764417642	-0.5283939702496686	0.04746152608851087	0.1239336718608812	-0.15728568243426577	0.13107405529193525	0.24563833030695764	0.054006271622496146	Nucleotide metabolism and transport	Uncharacterized membrane protein YczE (YczE)	NA	uncharacterized protein	NA
2307	0.14504022567210242	0.10388669059789017	-0.28743094231132893	0.03453005158027925	0.027955492050530887	-0.06733642754803146	0.09846778677630953	0.15273295751642316	0.027944667330200193	Function Unknown	Predicted membrane GTPase TypA/BipA involved in stress response (TypA) (PDB:5A9V)	Elongation factor G C-terminus;Elongation factor Tu GTP binding domain;50S ribosome-binding GTPase	GTP-binding protein	PF00679.25;PF00009.28;PF01926.24
2308	0.06458013124227395	0.1270052361460492	-0.4024473156936227	0.08065946943662498	0.008303227346759616	-0.12777134352869318	0.06300651394599556	0.26775552927604046	0.018757488839196507	Inorganic ion transport and metabolism	Chaperonin GroEL (HSP60 family) (GroEL) (PDB:1AON)	TCP-1/cpn60 chaperonin family	chaperonin GroEL	PF00118.25
2309	0.13181739327627595	-0.04461242464769697	-0.3393214667086147	0.17866238376711224	0.042346740217775805	-0.12717659186086855	0.04794082614391054	0.11204125119501385	0.05051503387402299	Inorganic ion transport and metabolism	Co-chaperonin GroES (HSP10) (GroES)	Chaperonin 10 Kd subunit	chaperonin GroES	PF00166.22
2310	0.4119330619118859	0.11338660363484755	-0.009251003701547212	-0.17949826373832073	0.3373325137166548	0.11703527457475324	0.08075882347153185	-0.15352819189461522	0.09055954988991607	Cell motility	Ribonucleotide monophosphatase NagD, HAD superfamily (NagD) (PDB:1PW5)	Haloacid dehalogenase-like hydrolase;Haloacid dehalogenase-like hydrolase;HAD-hyrolase-like	NA	PF13419.7;PF13344.7;PF13242.7
2311	-0.07266857404082777	0.13537373666629454	0.23139462573012023	-0.05998849268118263	-0.06791604567842817	-0.0391932881126604	-0.12297831579368354	0.03257728127772371	0.11282608942357793	Energy production and conversion	FAD synthase (RibF) (PDB:1MRZ)	FAD synthetase;Riboflavin kinase	riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	PF06574.13;PF01687.18
2312	-0.0729574613665103	-0.21681619754029346	0.3390187949742161	-0.00993905380308121	-0.012956048821462248	0.0964530270978376	0.00998465003624408	-0.2768953958496534	0.06415601782658345	Signal Transduction	Isoleucyl-tRNA synthetase (IleS) (PDB:1FFY)	Anticodon-binding domain of tRNA ligase;tRNA synthetases class I (I, L, M and V);tRNA synthetases class I (C) catalytic domain;tRNA synthetases class I (M)	isoleucyl-tRNA synthetase [EC:6.1.1.5]	PF08264.14;PF00133.23;PF01406.20;PF09334.12
2324	0.22792875294096665	-0.04752105197586796	-0.16202495561411703	-0.2748019101554527	0.3533608443562233	0.0017626585547250303	-0.06707181342126943	0.10250420967204846	0.019633468721214832	NA	NA	Protein of unknown function (DUF2721)	NA	PF11026.9
2325	0.31338098692277633	0.04170154341261039	-0.033680433052877184	-0.1721854480240913	0.3385340102917151	-0.009943426219825763	0.005607183028433217	-0.03620156176367635	0.05300504352641773	Amino Acid metabolis and transport	NADPH:quinone reductase or related Zn-dependent oxidoreductase (Qor) (PDB:2VCY)	Alcohol dehydrogenase GroES-like domain;Zinc-binding dehydrogenase;Zinc-binding dehydrogenase	NADPH:quinone reductase [EC:1.6.5.5]	PF08240.13;PF00107.27;PF13602.7
2326	0.41727442366258505	0.019486982593008437	-0.3376049719315172	0.10411934482875794	0.24040275328364674	0.0862423304083368	0.48296290606768927	-0.09578137881758746	0.043553174039795535	Carbohydrate metabolism and transport	Redox-sensitive bicupin YhaK, pirin superfamily (YhaK) (PDB:1J1L) (PUBMED:18561187)	Pirin;Pirin C-terminal cupin domain	quercetin 2,3-dioxygenase [EC:1.13.11.24]	PF02678.17;PF05726.14
2331	0.02462902474163639	0.140019576155942	0.24141742513406741	-0.06449793273462336	0.15142323131108346	-0.0027575592394361854	-0.042631973772527365	-0.062341164624979704	0.09964658874280223	Signal Transduction	16S rRNA U1498 N3-methylase RsmE (RsmE) (PDB:1NXZ)	RNA methyltransferase	16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	PF04452.15
2332	0.22407836695875188	-0.023276217959803412	-0.0929980932683517	-0.19561873060129176	0.3518886612372898	-0.06636721563266378	-0.049069790988408385	0.08111647173589213	0.044259401176726235	Amino Acid metabolis and transport	Heme/copper-type cytochrome/quinol oxidase, subunit 2 (CyoA) (PDB:1CYW)	Cytochrome C oxidase subunit II, periplasmic domain;Cytochrome C oxidase subunit II, transmembrane domain	cytochrome c oxidase subunit II [EC:7.1.1.9]	PF00116.21;PF02790.16
2333	0.18833774075589227	0.07018258620820961	-0.2610792759344682	-0.1339876088398435	0.2255089436793952	-0.1088143549421553	-0.11778728746915776	0.2429979376648608	0.01038733432653669	Amino Acid metabolis and transport	Heme/copper-type cytochrome/quinol oxidase, subunit 1 (CyoB) (PDB:1AR1)	Cytochrome C and Quinol oxidase polypeptide I	cytochrome c oxidase subunit I [EC:7.1.1.9]	PF00115.21
2336	0.32032313910929594	0.0015675192772799157	-0.15328199537937026	-0.19184882618266785	0.3580683889826967	-0.017213089814595125	-0.05269305942316268	0.08925673428137333	0.015325503198383151	Amino Acid metabolis and transport	Heme/copper-type cytochrome/quinol oxidase, subunit 3 (CyoC) (PDB:1QLE)	Cytochrome c oxidase subunit III	cytochrome c oxidase subunit III [EC:7.1.1.9]	PF00510.19
2337	-0.2439644918554814	0.05330736525050484	-0.14043507785083353	0.20169379185514832	-0.3133375999710989	-0.028284961494840846	0.1022750552219186	0.16131368649768058	0.0955040581635628	Inorganic ion transport and metabolism	Cytochrome oxidase assembly protein ShyY1 (Shy1)	SURF1 family	surfeit locus 1 family protein	PF02104.16
2344	0.44184916022103987	-0.02108970543741313	-0.34243581816199203	-0.3012351368759725	0.38883677613398304	0.06830497600081538	-0.044007351999407876	0.10644418126440573	0.09595744486970872	Amino Acid metabolis and transport	Dehydrogenase (flavoprotein) (FixC) (PDB:4OPU)	Lycopene cyclase protein	lycopene beta-cyclase [EC:5.5.1.19]	PF05834.13
2345	-0.11478875010118345	-0.1050703101255561	0.4187185717781568	-0.11790206958386638	0.19753325225294222	0.18307581407204027	-0.30476398671889504	-0.12887411141216812	0.14363500778910732	Replication and repair	Phytoene/squalene synthetase (ERG9) (PDB:3WEK)	Squalene/phytoene synthase	NA	PF00494.20
2346	0.39538770535107426	0.04982532361353096	-0.19744854716128585	-0.16433990175450033	0.35001748909840036	-0.004762020760973384	0.0904165946955577	0.011147421861090811	0.055407021505600465	Function Unknown	Phytoene dehydrogenase-related protein (PDB:4REP)	Flavin containing amine oxidoreductase;FAD dependent oxidoreductase;FAD binding domain;FAD dependent oxidoreductase;Glucose inhibited division protein A;HI0933-like protein;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase	phytoene desaturase [EC:1.3.99.26 1.3.99.28 1.3.99.29 1.3.99.31]	PF01593.25;PF01266.25;PF00890.25;PF12831.8;PF01134.23;PF03486.15;PF13450.7;PF00070.28;PF07992.15
2347	0.10538876299444502	0.10828333550265956	-0.10982688994759429	0.014369776739733473	0.09689781166281615	-0.08025796737511157	0.040612273040800666	0.13873048866695398	0.06939412908914247	Amino Acid metabolis and transport	FoF1-type ATP synthase, membrane subunit b or b' (AtpF) (PDB:1B9U)	ATP synthase B/B' CF(0);Mitochondrial ATP synthase B chain precursor (ATP-synt_B)	F-type H+-transporting ATPase subunit b	PF00430.19;PF05405.15
2348	-0.18817101971071787	0.11733236475216682	-0.11005990856140123	0.05312284205478536	-0.1959998219017777	-0.20894181298645365	-0.042409750640668334	0.27346440226228347	0.10161914687369945	Amino Acid metabolis and transport	FoF1-type ATP synthase, membrane subunit b or b' (AtpF) (PDB:1B9U)	ATP synthase protein 8;ATP synthase B/B' CF(0);Fungal ATP synthase protein 8 (A6L);Plant ATP synthase F0	F-type H+-transporting ATPase subunit b	PF00895.21;PF00430.19;PF05933.14;PF02326.16
2350	0.1894924496256611	-0.017277408580042175	-0.2964300837066949	0.051310850198803847	0.04980014355196748	0.034677353585692246	0.19270745463348032	0.06091428243523464	0.02422013471450779	Amino Acid metabolis and transport	FoF1-type ATP synthase, membrane subunit a (AtpB) (PUBMED:22931285)	ATP synthase A chain	F-type H+-transporting ATPase subunit a	PF00119.21
2351	0.14096429887957965	0.14770189969580783	-0.40336580255024734	0.025606297996527274	0.028952713723655342	0.048710708305671015	0.026663903710079526	0.2553125539568667	0.05986194470379703	Amino Acid metabolis and transport	FoF1-type ATP synthase AtpZ/Atp1/AtpQ subunit, putative Ca2+/Mg2+ transporter (AtpZ) (PUBMED:12917488;23123906)	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	ATP synthase protein I	PF09527.11
2352	0.10589220460737706	0.13767283280596437	-0.18438242527616214	0.004773209787149866	0.054602628301781884	-0.02254610882341035	0.0621928023238136	0.16073951963578847	0.033243196493231646	General Functional Prediction only	DNA repair ATPase RecN (RecN) (PDB:4AD8)!!!Chromosome segregation ATPase Smc (Smc) (PDB:5XG3)	AAA ATPase domain;AAA domain, putative AbiEii toxin, Type IV TA system;AAA domain;RecF/RecN/SMC N terminal domain	chromosome segregation protein	PF13175.7;PF13304.7;PF13476.7;PF02463.20
2353	0.26537074096962343	0.009327541834229857	-0.22611795090485173	-0.03835616387466857	0.20278967516042168	0.08250170006140911	0.12846469246975328	0.02187240663918061	0.10036081388343261	Inorganic ion transport and metabolism	Protein thiol-disulfide isomerase DsbC (DsbG) (PDB:2HI7)	Thioredoxin	NA	PF13462.7
2357	0.3460669285560363	0.09566793666938216	-0.13293570388155038	-0.22281252051430556	0.3462419909343597	0.07079505536102317	0.0576936053728329	0.0063251473059967155	0.04159199194107287	General Functional Prediction only	DNA modification methylase (YhdJ) (PDB:1BOO)	N-6 DNA Methylase;DNA methylase;Restriction Enzyme Adenine Methylase Associated	site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72];modification methylase [EC:2.1.1.72]	PF02384.17;PF01555.19;PF18755.2
2358	0.374331046614455	-0.02620253128105733	-0.32578689178569376	-0.16332442023909077	0.2189043406015885	0.013383952378432	0.19642914003298562	0.04298744785079527	0.09051851632853193	General Functional Prediction only	Ribonuclease HII (RnhB) (PDB:1EKE)	Ribonuclease HII	ribonuclease HII [EC:3.1.26.4]	PF01351.19
2359	0.22854533408103064	-0.011620881357685216	-0.14532464206529358	-0.2921969568200435	0.24539518351464998	-0.037062205567052205	-0.04684411063823693	0.12188902426330207	0.12049014632368538	General Functional Prediction only	Uracil-DNA glycosylase (Udg4) (PDB:3IKB)	Uracil DNA glycosylase superfamily	uracil-DNA glycosylase [EC:3.2.2.27]	PF03167.20
2360	0.40644268173345505	0.059406706027827966	-0.23431825084537475	-0.14007546359248466	0.33183099443682806	0.018402994517807223	0.1019056949384432	0.01167710201712193	0.06915247043552633	Lipid metabolism	Flp pilus assembly protein TadD, contains TPR repeats (TadD) (PDB:3WXX)	Tetratricopeptide repeat;Tetratricopeptide repeat;Tetratricopeptide repeat;Tetratricopeptide repeat;Tetratricopeptide repeat;Tetratricopeptide repeat;Tetratricopeptide repeat	NA	PF00515.29;PF13424.7;PF13428.7;PF14559.7;PF07719.18;PF13176.7;PF13181.7
2361	0.12050280890837617	0.11181097015687744	0.0429397355700145	-0.025719922247788296	0.10993561110103228	0.06969973518800208	0.041113308098593745	-0.08684838418765034	0.11688982106480955	Replication and repair	4-diphosphocytidyl-2C-methyl-D-erythritol kinase (IspE) (PDB:1OJ4)	NA	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	NA
2362	-0.15247339896417844	0.03568617343721665	-0.37953981436821865	-0.004816512560236911	-0.08253924748153664	-0.17881244286674927	0.07472787809896511	0.39145232486573034	0.10080732039242767	Signal Transduction	tRNA nucleotidyltransferase/poly(A) polymerase (PcnB) (PDB:3WFR)	Poly A polymerase head domain;Probable RNA and SrmB- binding site of polymerase A	tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	PF01743.21;PF12627.8
2363	0.12100414573943497	0.114496168432212	-0.21173502900634117	-0.15911524526173831	0.10988558976514289	0.09434981310538704	0.032666229326744	0.1838964007840703	0.028981521559780354	Signal Transduction	Transcription elongation factor, GreA/GreB family (GreA) (PDB:1GRJ)	Transcription elongation factor, GreA/GreB, C-term;Transcription elongation factor, N-terminal	transcription elongation factor GreA	PF01272.20;PF03449.16
2364	-0.2543968581435169	0.009798632868473794	0.1785475154487298	-0.024069473160518495	-0.17841722231961105	0.11611391672580439	-0.17646996692951272	0.05829859384826515	0.0827503854100007	Energy production and conversion	Coproporphyrinogen-III oxidase HemH, oxygen-dependent (HemF) (PDB:3E8J)	Coproporphyrinogen III oxidase	coproporphyrinogen III oxidase [EC:1.3.3.3]	PF01218.19
2365	0.22904742804321898	0.11187155096587806	-0.01605622057211558	-0.16803980489760229	0.26782252037609544	0.08017983679411748	0.01976979260632342	-0.0112471849401672	0.07175812938471485	Signal Transduction	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain (TrmL) (PDB:4JAK)	SpoU rRNA Methylase family	tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]	PF00588.20
2366	-0.23252489757354217	-0.012981631513843893	0.11463731875138577	0.15754992777926674	-0.17445107096062484	-0.11231461820091078	-4.897783928625864e-4	0.057998984361835045	0.03173291194370592	Amino Acid metabolis and transport	Rieske Fe-S protein (QcrA/PetC) (PDB:5CXM) (PUBMED:27663073)	Rieske [2Fe-2S] domain;Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal	ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]	PF00355.27;PF10399.10
2367	0.21790005351794706	0.006992528636100049	0.015176233786242591	-0.10770194711553316	0.22795778966996252	-0.044365273172224294	0.048256651832596364	-0.0067823136356709645	0.010831825368306014	Amino Acid metabolis and transport	Cytochrome b subunit of the bc complex (QcrB/PetB) (PDB:1VF5)	Cytochrome b/b6/petB;Cytochrome b(C-terminal)/b6/petD;Cytochrome b(N-terminal)/b6/petB	ubiquinol-cytochrome c reductase cytochrome b subunit	PF00033.20;PF00032.18;PF13631.7
2369	0.05086827522150531	0.018861968546803404	0.09602664065233066	-0.09150695660764682	0.04654151256939075	-0.012785319140108217	-0.02298053761508987	-0.0037865190489064075	0.043681362441738494	Signal Transduction	Ribosome-binding ATPase YchF, GTP1/OBG family (GTP1) (PDB:2DWQ) (PUBMED:21527254)	Ferrous iron transport protein B;50S ribosome-binding GTPase;Protein of unknown function (DUF933)	NA	PF02421.19;PF01926.24;PF06071.14
2370	0.07441579722592784	-0.05453380388281286	-0.46493482454527446	0.28172252073055826	-0.18362179287161678	-0.2768144808065045	-0.029456784014354302	0.2250278576677375	0.04154389812256208	Signal Transduction	Peptidyl-tRNA hydrolase (Pth) (PDB:1RYB) (PUBMED:11835511)	Peptidyl-tRNA hydrolase	peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	PF01195.20
2371	0.08414044881409387	0.112581348978745	-0.11043405291378092	-0.09626880595003894	0.08636169753912794	0.026204092286751433	0.045846148175985604	0.07847367449712843	0.06612360571876809	Signal Transduction	Ribosomal protein L25 (general stress protein Ctc) (RplY) (PDB:1B75)	Ribosomal L25p family;Ribosomal protein TL5, C-terminal domain	large subunit ribosomal protein L25	PF01386.20;PF14693.7
2372	0.1323808039028672	0.12657398696210975	0.10646680990838348	-0.016785239869693113	0.12580280019749468	0.1229727432029015	0.03302818228584708	-0.05450731547294917	0.031905428639856015	Cell motility	Phosphoribosylpyrophosphate synthetase (PrsA) (PDB:1DKR)	Phosphoribosyl transferase domain;N-terminal domain of ribose phosphate pyrophosphokinase;Phosphoribosyl synthetase-associated domain;Uracil phosphoribosyltransferase	ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	PF00156.28;PF13793.7;PF14572.7;PF14681.7
2373	0.024400838351372658	-0.011992604241593806	-0.22404905608820638	0.15691799025587197	0.007933063247558408	-0.10569881861990885	0.03923572618874662	0.1461837191338168	0.15678372639133362	Lipid metabolism	Copper oxidase (laccase) domain (YfiH) (PDB:1RV9)	Multi-copper polyphenol oxidoreductase laccase	polyphenol oxidase [EC:1.10.3.-]	PF02578.16
2374	0.005746241857231652	0.07567111437064503	-0.15283197958604555	0.12172138009180053	-0.009336157414725835	0.05189949892152343	0.13870088656529753	0.09344903165348256	0.14757012540264672	Carbohydrate metabolism and transport	SAM-dependent methyltransferase, MidA family (MidA) (PDB:1ZKD)	Putative S-adenosyl-L-methionine-dependent methyltransferase	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 7	PF02636.18
2375	0.327196634705339	0.05179002954536943	-0.19270985940989016	-0.19739827162830345	0.2935179337433969	0.02979307590555337	0.08012881974627577	0.05055165442592616	0.12120576480374638	Energy production and conversion	Prolipoprotein diacylglyceryltransferase (Lgt) (PDB:5AZB)	Prolipoprotein diacylglyceryl transferase	phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]	PF01790.19
2376	-0.35570640233391626	-0.10845825436756878	0.19752816668803885	-0.026036794353967652	-0.14880732145602946	0.023873799830786198	-0.07723975935601991	-0.052214400957447366	0.08142366136474508	NA	NA	NA	NA	NA
2377	0.08976974414128631	0.040505445003834135	-0.38246000491869825	0.13419865545938917	0.012794255747050775	0.06384748081245797	0.12319254420547639	0.13618711276568407	0.06809017167050319	Function Unknown	K+-sensing histidine kinase KdpD (KdpD) (PDB:2KSF)	HAMP domain;Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase;Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase;His Kinase A (phospho-acceptor) domain	two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]	PF00672.26;PF02518.27;PF13589.7;PF00512.26
2378	-0.16199641593025493	-0.005915586726257506	0.4119272469903991	-0.037828441480301025	0.015150136659616483	-2.132068518302528e-5	-0.2078765723033932	-0.11901621066908637	0.056470966955369795	Function Unknown	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain (OmpR) (PDB:1XHF)	Response regulator receiver domain;Transcriptional regulatory protein, C terminal	NA	PF00072.25;PF00486.29
2379	0.3304986117607921	-0.041621069183770634	-0.5278129424721463	-0.08719265245648164	0.12838728804161903	0.11637966835617168	0.20975373814708237	0.12115280034762889	0.05901540407110337	Signal Transduction	DNA-binding transcriptional regulator, MarR family (MarR) (PDB:1JGS)	MarR family;MarR family	NA	PF01047.23;PF12802.8
2380	0.29145223666347997	0.13076213054649244	-0.23853956433910672	-0.09363236293329932	0.2330293873487192	0.051986219062221756	0.09057468530625155	0.10149419071153419	0.023096382592550164	RNA processing and modification	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase (IlvE) (PDB:1A3G)	Amino-transferase class IV	branched-chain amino acid aminotransferase [EC:2.6.1.42]	PF01063.20
2381	0.3920029216153522	0.08647187072410943	-0.5316093325228658	-0.057001623999604456	0.23052159829014465	0.07520419035114487	0.11180099087679075	0.18846041442546077	0.023572882103503848	Replication and repair	Phosphatidylglycerophosphate synthase (PgsA) (PDB:4MND)	CDP-alcohol phosphatidyltransferase	cardiolipin synthase (CMP-forming) [EC:2.7.8.41];CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	PF01066.22
2385	0.20094024878165417	-0.004993149642997954	-0.20186230209457603	-0.016550433266021194	0.21208390489238907	-0.13515439398760015	0.08686754003123016	0.09255858790739667	0.016820674078896015	General Functional Prediction only	Excinuclease UvrABC helicase subunit UvrB (UvrB) (PDB:1C4O)	Helicase conserved C-terminal domain;Type III restriction enzyme, res subunit;UvrB/uvrC motif;Ultra-violet resistance protein B;UvrB interaction domain	excinuclease ABC subunit B	PF00271.32;PF04851.16;PF02151.20;PF12344.9;PF17757.2
2435	-0.02933279901644731	0.09541002134469034	-0.21199145696092367	0.05116776394090104	-0.04479952850388166	-0.17440861009560393	-5.350061337066154e-4	0.23174823118338778	0.02901065681175858	RNA processing and modification	Carbamoylphosphate synthase large subunit (CarB) (PDB:1C30)	ATP-grasp domain;ATP-grasp domain;ATP-grasp in the biosynthetic pathway with Ter operon;Carbamoyl-phosphate synthase L chain, ATP binding domain;Carbamoyl-phosphate synthetase large chain, oligomerisation domain;D-ala D-ala ligase C-terminus;MGS-like domain;RimK-like ATP-grasp domain	carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	PF02222.23;PF02655.15;PF15632.7;PF02786.18;PF02787.20;PF07478.14;PF02142.23;PF08443.12
2436	0.11416048931440924	-0.02104656254689809	0.007371191463597389	-0.23635663867671688	0.31374517957356185	-0.07753588219233194	-0.0053590725708374445	0.07723919253027091	0.06119062558226314	RNA processing and modification	Carbamoylphosphate synthase small subunit (CarA) (PDB:1C30)	Carbamoyl-phosphate synthase small chain, CPSase domain;Glutamine amidotransferase class-I;Peptidase C26	carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	PF00988.23;PF00117.29;PF07722.14
2437	0.250506911842817	0.07347375819792401	-0.3304098105999515	-0.18032648682370078	0.26706775402047417	0.0035902850791353176	0.003941500431477209	0.197176000017017	0.048385965587283176	Carbohydrate metabolism and transport	Uncharacterized conserved protein YqeY, may have tRNA amino acid amidase activity (YqeY) (PDB:1NG6)	Yqey-like protein	uncharacterized protein	PF09424.11
2438	0.20852641682133471	-0.19812502327699255	-0.1315038579376016	-0.08409655050578861	0.09218970808504044	0.06711537210694142	0.05289318625519478	-0.05980222523010728	0.054067715225984005	General Functional Prediction only	DNA primase (bacterial type) (DnaG) (PDB:3B39) (PUBMED:28128549)	Toprim domain;Toprim-like;Toprim domain;DNA primase catalytic core, N-terminal domain;CHC2 zinc finger	DNA primase [EC:2.7.7.101]	PF01751.23;PF13155.7;PF13662.7;PF08275.12;PF01807.21
2445	0.2058286770943248	0.09237061270198055	-0.4315381583198072	-0.06026014435937709	0.12828024415607486	-0.09143109816450197	0.050062356530526604	0.24500277082597433	0.049002981591198515	Signal Transduction	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity (MraZ) (PDB:1N0E)	MraZ protein, putative antitoxin-like	MraZ protein	PF02381.19
2446	0.35758330708996416	-0.10201357375330829	0.13845710437257264	-0.20805828581779875	0.3683525833492294	0.11963586720567562	-0.07426131647357517	-0.20895409705796955	0.041114132925617566	Energy production and conversion	Cell division GTPase FtsZ (FtsZ) (PDB:1FSZ)	FtsZ family, C-terminal domain;Tubulin/FtsZ family, GTPase domain	cell division protein FtsZ	PF12327.9;PF00091.26
2447	0.2655638886853694	-0.026633139341510965	0.08460223464822188	-0.2610045091260357	0.2556784118689452	0.12436857210917998	-0.032630950823362086	-0.2301962262512589	0.1275568773785824	Signal Transduction	16S rRNA C1402 N4-methylase RsmH (RmsH) (PDB:1M6Y)	MraW methylase family	16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	PF01795.20
2448	-0.3446804604273053	0.02725979680444097	0.24490331477759092	0.17893892393393224	-0.33600296521653944	-0.007133431561367326	-0.14858471992368294	-0.016140088274259095	0.21588926947991416	NA	NA	NA	NA	NA
2449	0.2747914917667061	0.006928172386243422	0.042125766982325674	-0.27436234915532676	0.31706792881613527	0.22485405557867633	0.011640622341078263	-0.1393041513608567	0.09966258972894702	Energy production and conversion	Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) (FtsI) (PDB:6HZQ)	Penicillin-binding Protein dimerisation domain;Penicillin binding protein transpeptidase domain	cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	PF03717.16;PF00905.23
2450	-0.027404527050248068	-0.09628441232022647	0.17515865573660777	0.056409118428756184	-0.039002133692596246	0.14398636241912435	0.031873407127364375	-0.10780753780217628	0.1608152526102537	Energy production and conversion	UDP-N-acetylmuramyl tripeptide synthase (MurE) (PDB:1E8C)!!!UDP-N-acetylmuramyl pentapeptide synthase (MurF) (PDB:4CVK)	Mur ligase family, catalytic domain;Mur ligase family, glutamate ligase domain;Mur ligase middle domain	MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10];UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10];UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]	PF01225.26;PF02875.22;PF08245.13
2451	-0.4204323192685147	-0.0814909669273312	0.06237855598924061	0.167466182229232	-0.3189764855579942	-0.0388311431407791	-0.014042661290730582	0.10046693860107468	0.04652373540196917	Energy production and conversion	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase (Rfe) (PDB:4J72)	Glycosyl transferase family 4	phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	PF00953.22
2452	0.15203790421806346	0.18837812602579834	-0.22916543892728125	-0.006254509210039647	0.140310276348753	-0.11143481045638594	0.041223577631627095	0.17704032805044315	0.1403797629845361	Energy production and conversion	UDP-N-acetylmuramoylalanine-D-glutamate ligase (MurD) (PDB:1E0D)	Mur ligase middle domain	UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]	PF08245.13
2453	-0.08104678192590942	0.12574202059535666	0.3137109579683305	-0.036175151966326265	0.0063412336707509955	0.17331842890386706	-0.13020856566789854	-0.1780704301643738	0.1188659862691972	Energy production and conversion	Peptodoglycan polymerase FtsW/RodA/SpoVE (FtsW) (PDB:6BAR) (PUBMED:30692671)	Cell cycle protein	cell division protein FtsW	PF01098.20
2454	0.1812981996902999	-0.006571063748261211	-0.05106322601160229	-0.1846257097876483	0.19995990611905962	-0.01031532548717599	-0.08442603464145262	0.042971990386565566	0.15335062165333638	Energy production and conversion	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase (MurG) (PDB:1F0K)	Glycosyltransferase family 28 N-terminal domain;Glycosyl transferase family 1;Glycosyltransferase family 28 C-terminal domain	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	PF03033.21;PF13528.7;PF04101.17
2455	-0.04010355205564163	-0.11446958490457138	-0.18047831843069334	0.05571751413580803	-0.030646775015806527	-0.15397921450683308	-0.013257203647965912	0.1776125873094094	0.06702301350711214	Energy production and conversion	UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family (MurC)	Mur ligase family, catalytic domain;Mur ligase family, glutamate ligase domain;Mur ligase middle domain	UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]	PF01225.26;PF02875.22;PF08245.13
2456	0.1674177303497584	-0.18348435535939556	0.275225692213957	-0.09955799442405186	0.16415208826012367	0.17240095332776792	-0.14254036661872813	-0.24710099603520572	0.101659515610545	Energy production and conversion	UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) (PDB:2MBR)	FAD binding domain;UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	PF01565.24;PF02873.17
2464	-0.21589555986136105	0.023480671817853183	0.15072724728637832	0.03663482992668219	-0.1440447214174649	0.052788972383722245	-0.025283945096595765	0.043159733620448275	0.04517604020734055	General Functional Prediction only	Superfamily I DNA or RNA helicase (UvrD) (PDB:6PPR)	AAA domain;AAA domain;UvrD/REP helicase N-terminal domain;UvrD-like helicase C-terminal domain;UvrD-like helicase C-terminal domain;Viral (Superfamily 1) RNA helicase	DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	PF13245.7;PF13604.7;PF00580.22;PF13361.7;PF13538.7;PF01443.19
2466	0.11584917315143099	0.18570991028658965	-0.29488877753183673	0.048208503485054593	0.14004457271242496	-0.05081118365266095	0.07036729681048907	0.25293639775737936	0.028514797301956562	Amino Acid metabolis and transport	Fumarate hydratase class II (FumC) (PDB:1KQ7)	Fumarase C C-terminus;Lyase	fumarate hydratase, class II [EC:4.2.1.2]	PF10415.10;PF00206.21
2467	0.12140128783064025	0.04207025284159804	-0.061041960951417736	-0.12951374192574405	0.12546109863535856	-0.08700377785848204	-0.03220530418040526	0.09832842864844617	0.026678639978633897	Cell motility	NTP pyrophosphatase, MazG superfamily (MazG2) (PDB:3NL9)	Phosphoribosyl-ATP pyrophosphohydrolase	NA	PF01503.18
2468	-0.0011247563256690054	-0.24308825047176072	0.19853336566993882	0.012193088248517442	-0.08957551377557627	0.21702759618414902	-0.03423662589519738	-0.25633251026639214	0.0924082950646075	Energy production and conversion	Nicotinate-nucleotide pyrophosphorylase (NadC) (PDB:1O4U)	Quinolinate phosphoribosyl transferase, C-terminal domain;Quinolinate phosphoribosyl transferase, N-terminal domain	nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	PF01729.20;PF02749.17
2470	0.329689089239996	0.006736874798831705	-0.12909288553544615	-0.028232047269694357	0.2080896950055458	-0.08816471455800824	-0.10073131747136137	3.468679885771206e-4	0.20620359798474433	NA	NA	NA	NA	NA
2471	0.4137246304675805	-0.1169479569099909	-0.2724896719949301	-0.20378786864484835	0.3014685273919291	0.0769276053539289	0.011784447350979336	-0.04622403916749273	0.08109367857337604	Inorganic ion transport and metabolism	Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters (YgfZ) (PDB:1NRK) (PUBMED:27941785;22081392)	Aminomethyltransferase folate-binding domain	tRNA-modifying protein YgfZ	PF01571.22
2472	0.13244069173861	-0.0010807511646841455	-0.28461991215350296	0.09456995823239174	0.03426771134900818	-0.08162624558747829	0.02705524512202034	0.15333959625502172	0.030710289345741774	Cell motility	Dihydroorotase or related cyclic amidohydrolase (AllB) (PDB:1J79)	Amidohydrolase family;Amidohydrolase family	dihydroorotase [EC:3.5.2.3]	PF01979.21;PF07969.12
2474	0.09026140095814561	-0.2408318445995802	0.21609980236691437	-0.10599832570366155	0.18870331070109478	0.07627972891679427	0.012539431602032707	-0.1733997682309157	0.027438203631963816	Replication and repair	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase (Acs) (PDB:4B2O) (PUBMED:14638756)	Acetyl-coenzyme A synthetase N-terminus;AMP-binding enzyme;AMP-binding enzyme C-terminal domain	propionyl-CoA synthetase [EC:6.2.1.17]	PF16177.6;PF00501.29;PF13193.7
2481	0.07650568394673077	0.145844040937119	-0.3710566332319699	-0.035642321288152354	0.0947310125945376	-0.11102207936396212	-0.038886549798954624	0.3082584468178963	0.0665811524422515	Signal Transduction	RNA polymerase-binding transcription factor DksA (DksA) (PDB:1TJL)	Prokaryotic dksA/traR C4-type zinc finger	DnaK suppressor protein	PF01258.18
2486	0.09681755125652489	0.0711365479044365	-0.5195017628121438	-0.023646809173939364	0.060202749788521484	-0.12666967082163416	0.1434235424281188	0.31484480957006	0.02020552528700162	Cell motility	IMP dehydrogenase/GMP reductase (GuaB) (PDB:1B3O)	IMP dehydrogenase / GMP reductase domain	GMP reductase [EC:1.7.1.7]	PF00478.26
2487	-0.2890693904843867	-0.24430125065093003	0.18502862219711796	0.11111687552669539	-0.16143317359505943	-0.11670402753920399	-0.08731130109054655	-0.06450484157557383	0.05270591961209169	Energy production and conversion	Hypoxanthine phosphoribosyltransferase (Hpt1) (PDB:2JKZ)	Phosphoribosyl transferase domain	uncharacterized protein	PF00156.28
2492	0.05906397796219319	-2.205268610972734e-4	-0.2818842426948964	0.01409286154105559	0.1547217849197045	-0.08479847911300269	-0.1679245262612952	0.2643407803403718	0.056431782541950304	Nucleotide metabolism and transport	Uncharacterized conserved protein (PDB:1X6M)	Glutathione-dependent formaldehyde-activating enzyme	NA	PF04828.15
2493	0.2503585709507576	-0.01052996451557412	-0.3859797745029961	-0.1706659187316611	0.17449845755432147	-0.0761559014275854	0.04774035502217999	0.19266832479705728	0.07052976622293067	Carbohydrate metabolism and transport	Pantothenate kinase-related protein Tda10 (topoisomerase I damage affected protein) (Tda10) (PDB:1ODF)	NA	D-glycerate 3-kinase [EC:2.7.1.31]	NA
2496	-6.7061668928086e-4	-0.10806947970488863	-0.5034016281487511	0.09252484987697275	-0.0461064541743267	-0.17110851578078404	0.10654630264538496	0.28078045468352725	0.03393605636638646	Signal Transduction	Alanyl-tRNA synthetase (AlaS) (PDB:2ZZE)	DHHA1 domain;tRNA synthetases class II (A);Threonyl and Alanyl tRNA synthetase second additional domain	alanyl-tRNA synthetase [EC:6.1.1.7]	PF02272.20;PF01411.20;PF07973.15
2497	0.11554518422959342	0.03562087923709547	-0.4900546813096927	0.22102441961480276	0.06780750912683269	0.1027405865491786	0.14762221687117044	0.2169557891560258	0.01986422314523354	Amino Acid metabolis and transport	Isocitrate dehydrogenase (Icd) (PDB:1IDD)	Isocitrate/isopropylmalate dehydrogenase	isocitrate dehydrogenase [EC:1.1.1.42]	PF00180.21
2498	0.1761093630648466	0.16426049351827113	-0.43684536903939114	0.09257798068523913	0.045318889884975185	-0.09603738243705134	0.08971809746326721	0.24048850590415521	0.026963595846665852	Replication and repair	Phosphatidylserine decarboxylase (Psd) (PDB:6L06)	Phosphatidylserine decarboxylase	phosphatidylserine decarboxylase [EC:4.1.1.65]	PF02666.16
2501	0.3238982551329385	-0.03648298463647264	-0.022433587784172676	-0.3038703813240304	0.41051496476775523	0.11641697618223032	0.05998377981342524	-0.052943711775783706	0.05282404862883393	Signal Transduction	23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ (RlmE) (PDB:1EIZ) (PUBMED:10769117)	FtsJ-like methyltransferase	23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166]	PF01728.20
2502	0.3598545531903532	0.09578761794759544	-0.11174707095211149	-0.05383379057334796	0.31369614286119335	0.09555422556005241	0.11075367002139462	-0.03788141635009766	0.060006445462798215	Cell motility	IMP dehydrogenase/GMP reductase (GuaB) (PDB:1B3O)	FMN-dependent dehydrogenase;Conserved region in glutamate synthase;IMP dehydrogenase / GMP reductase domain;Putative N-acetylmannosamine-6-phosphate epimerase;Nitronate monooxygenase	IMP dehydrogenase [EC:1.1.1.205]	PF01070.19;PF01645.18;PF00478.26;PF04131.15;PF03060.16
2503	0.25469248060227867	0.06149757096691563	0.09081797542216966	-0.2549102458063627	0.3745277717438272	-0.003560949222307751	-0.05420410458942304	-0.023690367620321368	0.1135891302280704	NA	NA	NA	NA	NA
2504	0.19097240900407758	0.005078396700537469	0.03985415480726868	-0.13756444515970637	0.2732069099271671	0.011173117856800877	-0.03496394609920867	-0.007816971420036298	0.03560429864058262	Cell motility	GMP synthase, glutamine amidotransferase domain (GuaA1) (PDB:4WIM)!!!GMP synthase, PP-ATPase domain/subunit (GuaA2) (PDB:4WIM)	Asparagine synthase;PP-loop family;Glutamine amidotransferase class-I;GMP synthase C terminal domain;NAD synthase;Phosphoadenosine phosphosulfate reductase family;Peptidase C26;Queuosine biosynthesis protein QueC;tRNA methyl transferase	GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	PF00733.22;PF01171.21;PF00117.29;PF00958.23;PF02540.18;PF01507.20;PF07722.14;PF06508.14;PF03054.17
2507	-0.025900612189322315	0.10047644491481901	-0.019224959775204	-0.11597904322567033	0.03704329439450717	-0.05066175816130208	-0.016715861157856324	0.02661310823788627	0.10180103783416514	Energy production and conversion	Ketopantoate hydroxymethyltransferase (PanB) (PDB:3VAV)	Ketopantoate hydroxymethyltransferase	3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]	PF02548.16
2508	0.3818177197684322	-0.047035663342889666	-0.27159717152719903	-0.2057176100303948	0.4027518962894008	0.033902629365793316	0.040230479040373	0.10945258651903762	0.03739732376540301	Lipid metabolism	Tellurite resistance membrane protein TerC (TerC)	Integral membrane protein TerC family	NA	PF03741.17
2510	-0.22039928394767938	0.03640429716444977	-0.4323573720025702	0.21071816434264556	-0.23572841668527997	-0.16313165234036986	-0.016703023901049857	0.4243765043225084	0.06963341437965254	RNA processing and modification	5-oxoprolinase subunit A (PxpA) (PDB:1V6T) (PUBMED:28830929)	LamB/YcsF family	5-oxoprolinase (ATP-hydrolysing) subunit A [EC:3.5.2.9]	PF03746.17
2511	0.19150933246518792	0.11879857780873862	-0.22207587802502052	-0.11315392657811288	0.16361360771948918	0.03930532449699172	0.14765068899524336	0.09141318346216372	0.06650848965790433	RNA processing and modification	5-oxoprolinase subunit B/Allophanate hydrolase subunit 1 (PxpB) (PDB:2KWA) (PUBMED:28830929)	Carboxyltransferase domain, subdomain C and D	inhibitor of KinA	PF02682.17
2512	0.15259562439257562	0.028195045607338844	-0.2903889187877047	-0.02217788631602076	0.13714823166515014	-0.06260170946981874	0.08612038348368956	0.16035141926851068	0.07358581400157314	RNA processing and modification	5-oxoprolinase subunit C/Allophanate hydrolase subunit 2 (PxpC) (PDB:3MML) (PUBMED:28830929)	Carboxyltransferase domain, subdomain A and B	5-oxoprolinase (ATP-hydrolysing) subunit C [EC:3.5.2.9]	PF02626.16
2513	0.34549856405792795	0.02115776931266587	-0.29072511180531346	-0.15344689025676747	0.3482662790924434	0.11343600859325594	0.03459712670097373	0.06796507607786105	0.057285461484456394	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	NA	PF00892.21
2514	0.07422648772853646	0.1768996486746411	-0.242772784725434	-0.0720285586430305	0.07272839956361428	-0.06384027556170037	0.02564097072100156	0.21164180070860625	0.06283760734104614	RNA processing and modification	Glycine cleavage system protein T (aminomethyltransferase) (GcvT) (PDB:2GAH) (PUBMED:25433025;25505271)	Aminomethyltransferase folate-binding domain;Glycine cleavage T-protein C-terminal barrel domain	aminomethyltransferase [EC:2.1.2.10]	PF01571.22;PF08669.12
2515	-0.04905040638426032	0.11541608917312783	-0.27645924253387333	0.0813091390091823	-0.1079857299923074	-0.10720870797651708	0.07721975773597875	0.22543985323001536	0.029568865309909736	RNA processing and modification	Glycine cleavage system protein H (lipoate-binding) (GcvH) (PDB:1DXM)	Glycine cleavage H-protein	glycine cleavage system H protein	PF01597.20
2516	-6.107971299931758e-4	0.07780948294041444	-0.36717795343592535	0.03889818708808506	0.015301094431228917	-0.03144144711329094	-0.007329587155361894	0.30161229666026446	0.026624338800044077	RNA processing and modification	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain (GcvP1) (PDB:4LGL)!!!Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain (GcvP2) (PDB:4LGL)	Aminotransferase class-V;Beta-eliminating lyase;Glycine cleavage system P-protein	glycine dehydrogenase [EC:1.4.4.2]	PF00266.20;PF01212.22;PF02347.17
2517	-0.36424334474121	0.09917142265950543	-0.05093124638556517	0.23492405303295075	-0.3495075350274434	-0.08391927008741329	-0.03861663388401093	0.23036078336619575	0.06826496364717678	Carbohydrate metabolism and transport	Predicted flavin-containing amine oxidase (Ppro0129)	Flavin containing amine oxidoreductase;FAD dependent oxidoreductase;NAD(P)-binding Rossmann-like domain	uncharacterized protein	PF01593.25;PF01266.25;PF13450.7
2518	-0.07413772118112162	0.051336453291486187	-0.21390287338069758	0.12303954900818832	-0.09164760950091881	-0.058702223999321006	-0.04961649988768551	0.1978810132616108	0.08110930579122119	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF1365 family	Protein of unknown function (DUF1365)	uncharacterized protein	PF07103.12
2519	-0.035619269300078665	0.13222243796130415	-0.21844387710093757	0.06900682776192957	-0.08897511662972234	-0.004064062842908229	0.1653059711345373	0.13224403799867832	0.05223050206593685	Replication and repair	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases (Cfa) (PDB:5Z9O)	Mycolic acid cyclopropane synthetase;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain;Methyltransferase domain	cyclopropane-fatty-acyl-phospholipid synthase [EC:2.1.1.79]	PF02353.21;PF08241.13;PF08242.13;PF13489.7;PF13649.7
2520	-0.07376333182536907	0.11688789927013038	0.0839844079308819	0.07762520919999807	-0.05213844978152547	-0.0031350110837404604	0.005547962667619915	0.05392975027172042	0.0341647010864879	NA	NA	Protein of unknown function (DUF3833)	NA	PF12915.8
2521	0.08646045779709327	0.1358974501759534	0.14527850355204075	-0.1680242278506781	0.16192577009074308	0.004055068703112343	-0.07036229733756652	0.007216341763295726	0.05442094531610813	Carbohydrate metabolism and transport	Short-chain dehydrogenase (YqjQ)	short chain dehydrogenase;Enoyl-(Acyl carrier protein) reductase;KR domain	NA	PF00106.26;PF13561.7;PF08659.11
2522	0.16862275802684196	-4.845361055978767e-4	0.10416186632022573	-0.017528562348849468	0.1817951856802411	-0.04225770176176601	0.00880457499558426	-0.07294844340311872	0.12088934396308085	Function Unknown	Tryptophan-rich sensory protein TspO/CrtK (mitochondrial benzodiazepine receptor homolog) (TspO) (PDB:2MGY)	TspO/MBR family	translocator protein	PF03073.16
2523	0.22084736801359445	0.037487128965302936	-0.5308534337511804	0.05278666709257425	0.05817134659961201	-0.0369145852280813	0.19664495551853628	0.2548071221172549	0.027301140782606117	RNA processing and modification	Glycine/D-amino acid oxidase (deaminating) (DadA) (PDB:3AWI)	FAD dependent oxidoreductase;NAD(P)-binding Rossmann-like domain;Pyridine nucleotide-disulphide oxidoreductase;Pyridine nucleotide-disulphide oxidoreductase	FAD-dependent oxidoreductase domain-containing protein 1	PF01266.25;PF13450.7;PF00070.28;PF07992.15
2533	-0.2881935851228355	0.13540075818181438	0.07182701384994465	0.3986105777186308	-0.3093216461699139	-0.06920020143718839	-0.053986579526696325	0.12254432859837588	0.03818002523831906	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	NA	PF00892.21
2534	0.2608983571915122	0.048579720876951095	-0.12644970323360316	-0.06916907296791117	0.22818730084859407	0.015624005662256604	0.0986978659727538	0.03537243666114737	0.032240711512648464	RNA processing and modification	Xaa-Pro aminopeptidase (PepP) (PDB:1A16)	Creatinase/Prolidase N-terminal domain;Metallopeptidase family M24	creatinase [EC:3.5.3.3]	PF01321.19;PF00557.25
2535	0.2573792569874777	0.04283058531826282	-0.4473670915954779	-0.07011953953266883	0.15836034170232666	-0.055950654447227785	0.17365072469551135	0.21389007677664848	0.023616976017493845	RNA processing and modification	N-Dimethylarginine dimethylaminohydrolase (DdaH) (PDB:6LRH)	Amidinotransferase	glycine amidinotransferase [EC:2.1.4.1]	PF02274.18
2537	0.2786052891301827	-0.06862994099341846	-0.40967139110473055	0.028975503248589378	0.21420819377794587	-0.10326721903501324	0.11996734975007635	0.13786763141560074	0.04388981504239098	NA	NA	NA	NA	NA
2542	0.3040505025784128	0.09007368613795978	0.17837933524233998	-0.14055805928112328	0.36138465083350807	0.13653066124531216	0.037730915758005426	-0.1426459318780197	0.12826881628544484	NA	NA	NA	NA	NA
2546	-0.20311519059022456	-0.23947636522841206	0.2457010641544363	0.026712057617474937	-0.13451990867000752	0.13564273929367843	0.021769170922524513	-0.14060546413422045	0.0732021387959859	Function Unknown	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family (PhyH) (PDB:2A1X)	Phytanoyl-CoA dioxygenase (PhyH)	non-haem Fe2+, alpha-ketoglutarate-dependent halogenase	PF05721.14
2551	0.09675615559948697	0.01456735590396384	0.15853384114966385	-0.20839657011758686	0.24813654648620678	0.03221867144887925	-0.007419193653830092	-0.04154756369526945	0.11310406654834625	RNA processing and modification	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily (LysX) (PDB:1GLV)	Prokaryotic glutathione synthetase, ATP-grasp domain;Prokaryotic glutathione synthetase, N-terminal domain;RimK-like ATP-grasp domain	glutathione synthase [EC:6.3.2.3]	PF02955.17;PF02951.15;PF08443.12
2554	0.17395642382034973	0.11488196607720279	0.048436325954795814	-0.11671837169734624	0.2198077604266229	0.023672473597145995	0.024028413728016285	-0.009608306506294998	0.024564324779041632	Cell motility	Glutamine phosphoribosylpyrophosphate amidotransferase (PurF) (PDB:1ECB)	Glutamine amidotransferase domain;Glutamine amidotransferase domain	amidophosphoribosyltransferase [EC:2.4.2.14]	PF13522.7;PF13537.7
2557	0.13143057465577127	-0.023215663432994697	-0.22712759490000795	-0.02081615258157071	0.09601998430476465	-0.03315872868760296	0.07187716250807387	0.14484976532577692	0.015656472346535052	General Functional Prediction only	Replicative DNA helicase (DnaB) (PDB:1B79)	AAA domain;KaiC;DnaB-like helicase N terminal domain;DnaB-like helicase C terminal domain;Rad51	replicative DNA helicase [EC:3.6.4.12]	PF13481.7;PF06745.14;PF00772.22;PF03796.16;PF08423.12
2558	0.050202821666620386	0.13288997396335325	-0.39170116837058927	0.03332124622456133	0.02441761220823421	-0.08450543902112313	0.05133411161158446	0.27029438577738085	0.05207206027617886	Signal Transduction	Ribosomal protein L9 (RplI) (PDB:1VS6) (PUBMED:27112601)	Ribosomal protein L9, C-terminal domain;Ribosomal protein L9, N-terminal domain	large subunit ribosomal protein L9	PF03948.15;PF01281.20
2561	0.27220122662586643	-0.09158353077608951	-0.036547957926839084	-0.002625339748817866	0.24476476355004603	-0.006710118263796909	0.09465259243888492	-0.07605957527369282	0.10353089910040919	Replication and repair	Malonyl CoA-acyl carrier protein transacylase (FabD) (PDB:1YXC)	Acyl transferase domain	[acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	PF00698.22
2563	0.0808232327402747	-0.08838092107156642	-0.5007721937380172	0.2538223053387471	-0.14825591088711348	-0.1424246625090209	0.2280507916411142	0.202267100692448	0.008173785400355786	Replication and repair	Acyl carrier protein (AcpP) (PDB:1ACP)	Phosphopantetheine attachment site	acyl carrier protein	PF00550.26
2572	0.14460195917186214	-0.07091206091806115	-0.26527109971445106	0.05454593777380092	0.0980047610892989	0.05603842935375544	0.14616200493739107	0.05306420127421456	0.04891083360224331	Cell motility	Nucleoside diphosphate kinase (Ndk) (PDB:1B4S)	Nucleoside diphosphate kinase	nucleoside-diphosphate kinase [EC:2.7.4.6]	PF00334.20
2574	0.18961146351616984	0.08618390589768939	0.021787192582024616	-0.010496521433086785	0.1843188269251324	0.029986458791333513	0.29076033810814483	-0.05917842258323655	0.09939903476093613	Cell motility	Phosphoribosylaminoimidazole (AIR) synthetase (PurM) (PDB:1CLI)	AIR synthase related protein, N-terminal domain;AIR synthase related protein, C-terminal domain	phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	PF00586.25;PF02769.23
2575	-0.08726110097408885	0.04522382966859131	-0.2822839284644799	0.005725791683817551	-0.026716045920185085	-0.14415192877221727	-0.017216138205773807	0.28206551034253263	0.17916005624051592	NA	NA	NA	NA	NA
2576	0.34301000273547533	-0.177059318517452	-0.42558629510339957	-0.19336977735330976	0.22612304447381393	0.04210100193915474	0.2103428194158981	0.11807807151636522	0.1269057890392511	General Functional Prediction only	Chromosomal replication initiation ATPase DnaA (DnaA) (PDB:1L8Q)	Bacterial dnaA  protein	NA	PF00308.19
2577	0.11556019747911246	0.11831203876543883	-0.1524260630432821	-0.027970080499337944	0.11113000695657516	0.01896963839217517	0.03418126813376932	0.14753153129613103	0.057131203000612064	Signal Transduction	Aspartyl-tRNA synthetase (AspS) (PDB:1C0A)	GAD domain;tRNA synthetases class II (D, K and N);OB-fold nucleic acid binding domain	aspartyl-tRNA synthetase [EC:6.1.1.12]	PF02938.15;PF00152.21;PF01336.26
2578	-0.12450593264694625	-0.15446489415652187	0.4605566512712814	0.004047860363503146	-0.054445399690932574	0.21314737274339537	-0.0020433032894168006	-0.26934593246610256	0.05547986909417033	Cell motility	Ribonucleotide reductase alpha subunit (NrdA) (PDB:1R1R)	NA	NA	NA
2579	0.02428411866078771	-0.11100571762589682	-0.4846525839282337	0.09351036085153046	0.0037332347355235104	-0.1499713413083563	-0.01571993433317075	0.2866309524823459	0.08513468325153631	Amino Acid metabolis and transport	NADH:ubiquinone oxidoreductase NDUFA12 subunit (Leigh syndrome) (NDUFA12)	NADH ubiquinone oxidoreductase subunit NDUFA12	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12	PF05071.17
2580	-0.3056910579627361	-0.015472746699555258	0.0637325758756016	0.2828714694253667	-0.3825835358085869	-0.20634301112036257	-0.1442067844120806	0.04742856030272569	0.10496119701237286	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF2155 domain	Uncharacterized protein conserved in bacteria (DUF2155)	NA	PF09923.10
2581	0.24905460096467832	0.1032980182801749	-0.10100288638006184	-0.007991345965171967	0.13691568449476416	0.09648279720308695	0.16353178646742658	-0.03436819391724166	0.03293041339309803	Replication and repair	Acetyl/propionyl-CoA carboxylase, alpha subunit (PccA) (PDB:3U9S)	ATP-grasp domain;ATP-grasp domain;Biotin carboxylase C-terminal domain;Biotin carboxylase, N-terminal domain;Carbamoyl-phosphate synthase L chain, ATP binding domain;D-ala D-ala ligase C-terminus;Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	PF02222.23;PF02655.15;PF02785.20;PF00289.23;PF02786.18;PF07478.14;PF01071.20
2582	-0.08549427463520026	-0.02586329833521316	0.29154044198121964	0.1291611701828941	-0.14944645119564703	0.08345721625167231	0.17029545984569008	-0.2658985894139181	0.1234707710255484	Replication and repair	Biotin carboxyl carrier protein (AccB) (PDB:1A6X)	Biotin-requiring enzyme;Biotin-lipoyl like	acetyl-CoA carboxylase biotin carboxyl carrier protein	PF00364.23;PF13533.7
2583	-0.4375742237631026	-0.07642271235113124	0.016771003768880282	0.2516886234804535	-0.3994753911201083	-0.28394098948525703	-0.09479657510058864	0.1771727009674361	0.11746470697059815	RNA processing and modification	3-dehydroquinate dehydratase (AroQ) (PDB:1D0I)	Dehydroquinase class II	3-dehydroquinate dehydratase II [EC:4.2.1.10]	PF01220.20
2584	0.29712793375468516	0.04077194589235718	-0.5305235240923053	-0.02072434529755886	0.09302131101503225	0.019871205441184033	0.1662393048223941	0.2010014323781649	0.17729365339529077	Energy production and conversion	Sulfur carrier protein ThiS (thiamine biosynthesis) (ThiS) (PDB:1F0Z)	ThiS family	sulfur carrier protein	PF02597.21
2585	0.08401827952594473	0.10733643248916334	-0.22775470785178117	-0.10401333358060472	0.07946449804148573	-0.05935379194175849	-0.002162741648175179	0.2190031069604466	0.019095459700353857	Energy production and conversion	Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis) (ThiG) (PDB:1TYG)	Thiazole biosynthesis protein ThiG	thiazole synthase [EC:2.8.1.10]	PF05690.15
2586	-0.20133865433393183	-0.09867141888355971	0.34094651094783796	-0.06080142919851541	-0.09965978984228889	0.13367900566362315	-0.06287105403831732	-0.19537160720296992	0.05846386311507858	Signal Transduction	Ribonuclease G or E (CafA) (PDB:1SLJ)	Ribonuclease E/G family;S1 RNA binding domain	ribonuclease E [EC:3.1.26.12]	PF10150.10;PF00575.24
2587	0.20877739352103275	0.05311943635958973	-0.32085217254951376	-0.06544028733965981	0.088538544901074	-0.02892651972089183	0.058916698445394176	0.2015379428522332	0.08775144708084177	Energy production and conversion	Membrane carboxypeptidase/penicillin-binding protein (MrcA) (PDB:3D0F)	Penicillin-binding protein OB-like domain;Transglycosylase;Penicillin binding protein transpeptidase domain	penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	PF17092.6;PF00912.23;PF00905.23
2588	0.1967535314857903	0.06427287437176772	0.034172121411289114	-0.0567682648541564	0.15226236814130356	0.07235216202101778	0.14473613247462344	-0.06802083595193731	0.053471574712204754	Signal Transduction	Protein chain release factor PrfB (PrfB) (PDB:1GQE)	PCRF domain;RF-1 domain	peptide chain release factor 2	PF03462.19;PF00472.21
2589	-0.12556493034677077	-0.17588917985665048	0.06371426415351213	0.0031764466442441	-0.0818048895150117	0.012785749335566568	-0.15304109528275067	0.05509451397617054	0.18381095557524874	Nucleotide metabolism and transport	Uncharacterized conserved protein YhdP, contains DUF3971 and AsmA2 domains (YhdR)	AsmA-like C-terminal region	NA	PF13502.7
2590	-0.10960607360233604	-0.11550941273500524	0.44947398188586835	-0.037286096280021185	-0.014480973616411064	0.10794581872359912	-0.04317216453088426	-0.21876085351421962	0.06866881218308095	Signal Transduction	Tyrosyl-tRNA synthetase (TyrS) (PDB:4OUD)	S4 domain;tRNA synthetases class I (W and Y)	tyrosyl-tRNA synthetase [EC:6.1.1.1]	PF01479.26;PF00579.26
2591	0.019852856703046092	-0.18894981302403774	0.23094723421249086	0.018289250407387988	0.04151159836852189	0.04539265724763177	0.10436955777797133	-0.21131223041787647	0.1463748272532638	Energy production and conversion	1,6-Anhydro-N-acetylmuramate kinase (AnmK) (PDB:3CQY) (PUBMED:15901686)	Anhydro-N-acetylmuramic acid kinase	anhydro-N-acetylmuramic acid kinase [EC:2.7.1.170]	PF03702.15
2592	-0.09500848105808987	0.054228619782252734	-0.041165304907764565	0.06319761070823765	-0.16654938569901015	-0.02534985013956665	0.41114317938692657	-0.03927872468066572	0.03766645989420291	Carbohydrate metabolism and transport	Alpha/beta superfamily hydrolase (PDB:2FUK)	alpha/beta hydrolase fold;Dienelactone hydrolase family;Serine aminopeptidase, S33;X-Pro dipeptidyl-peptidase (S15 family);Prolyl oligopeptidase family	uncharacterized protein	PF00561.21;PF01738.19;PF12146.9;PF02129.19;PF00326.22
2593	-0.0036703577896359148	-0.11581088442293418	0.3075097276629169	-0.08525918629150812	0.1797035825905535	0.09487748440882114	-0.08894981706327816	-0.1508555757548814	0.03773615312697571	Signal Transduction	DNA-binding transcriptional regulator, IscR family (IscR) (PDB:1XD7)	Iron-dependent Transcriptional regulator	Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor	PF02082.21
2597	-0.19475350979705694	-0.06433503269725777	-0.005801776393314623	-0.08011031755107148	-0.15318971208508228	-0.17005759236859289	-0.024963828881677565	0.13818397197682855	0.042195608733229334	RNA processing and modification	Selenocysteine lyase/Cysteine desulfurase (CsdA) (PDB:4LW2)	Aminotransferase class I and II;Aminotransferase class-V;Beta-eliminating lyase;Cys/Met metabolism PLP-dependent enzyme;DegT/DnrJ/EryC1/StrS aminotransferase family	cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]	PF00155.22;PF00266.20;PF01212.22;PF01053.21;PF01041.18
2599	0.11990871294922857	0.09361966321100634	-0.07095344538490811	-0.12922475376492806	0.1831193807152637	-0.1299472112273354	-0.03918641954257411	0.09758593797642469	0.04294593798442161	Inorganic ion transport and metabolism	Metal-sulfur cluster biosynthetic enzyme (PaaD) (PDB:1UWD)	Iron-sulfur cluster assembly protein	NA	PF01883.20
2600	0.3599945110932961	0.08599403508448351	-0.1318254924336857	-0.20620415955251645	0.35575859381009023	0.044511499921565806	-0.051874982479689635	0.04713557431647106	0.037415060259496244	Inorganic ion transport and metabolism	Fe-S cluster assembly iron-binding protein IscA (IscA) (PDB:1R94)	Iron-sulphur cluster biosynthesis	iron-sulfur cluster assembly protein	PF01521.21
2601	0.5314999582774435	0.0920502068560266	-0.4801494226632459	-0.26808995415063624	0.35974228279215786	0.11673589040806179	0.14806772331175455	0.08459803519126473	0.033639979768328804	NA	NA	NA	NA	NA
2602	0.3384655202097903	0.006176130508606746	-0.1363972324676671	-0.21883352460699326	0.4125989365275044	0.03814714873355842	0.010506757143497986	0.044760637371859036	0.020490468777806265	RNA processing and modification	Glutamine synthetase (GlnA) (PDB:1F1H)	Glutamine synthetase, catalytic domain;Glutamine synthetase, beta-Grasp domain	glutamine synthetase [EC:6.3.1.2]	PF00120.25;PF03951.20
2603	0.24637164762964794	0.02430154146574296	-0.1762213653022344	-0.2779017296088294	0.24393678396793533	0.12116741621490607	0.08079116585900506	0.01044142758260822	0.10730009704959663	Signal Transduction	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC (EbsC) (PDB:1DBU)	Aminoacyl-tRNA editing domain	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	PF04073.16
2604	-0.2333673916425135	-0.1586483930358724	0.5159586185541383	-0.036557285050685936	0.020822774796771557	-0.004666707461419233	-0.20284577663067344	-0.14214089226069443	0.03679850362507152	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	O-acetylserine/cysteine efflux transporter	PF00892.21
2619	-0.14600281446991845	-0.15668517824246617	0.009722807158210714	0.1297337578416361	-0.2801318662167932	0.031741099056875645	0.10129131681082344	-0.11120933909803137	0.05697498253745926	Amino Acid metabolis and transport	Molybdopterin-dependent catalytic subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases (MsrP) (PDB:1OGP) (PUBMED:26641313;32750406)	Oxidoreductase molybdopterin binding domain	methionine sulfoxide reductase catalytic subunit [EC:1.8.-.-]	PF00174.20
2625	0.26722920297141806	0.0888482567917259	0.027110257855328695	-0.25278713802033	0.3419458543101677	0.02887069158124659	-0.03255326888170966	-0.033663749201711245	0.04467017260714917	Lipid metabolism	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component (TauC)	Binding-protein-dependent transport system inner membrane component	NitT/TauT family transport system permease protein;taurine transport system permease protein	PF00528.23
2626	0.05692122677359932	0.16471907923031615	-0.32119595383807625	0.040018220453768356	-0.06969508617668388	-0.10303855691331329	0.08860944162169675	0.23578964373464356	0.01649204221949233	Lipid metabolism	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component (TauB)	ABC transporter	taurine transport system ATP-binding protein [EC:7.6.2.7]	PF00005.28
2629	0.44131996083488734	-0.10187055614485362	-0.14994798829191602	-0.09578084677845611	0.3105171418213781	0.21571832881799574	0.12235426521569563	-0.19011711269909112	0.04203339815524312	RNA processing and modification	Alanine dehydrogenase (includes sporulation protein SpoVN) (Ald) (PDB:2EEZ)	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain;Alanine dehydrogenase/PNT, C-terminal domain;Alanine dehydrogenase/PNT, N-terminal domain;Shikimate / quinate 5-dehydrogenase	alanine dehydrogenase [EC:1.4.1.1]	PF02826.20;PF01262.22;PF05222.16;PF01488.21
2646	-0.20926700463388112	0.07336695887328012	-0.3951287993569184	0.12663307310069935	-0.22918169209785272	-0.24681291847643283	0.06535890951278804	0.31909569063827325	0.03390750347566849	RNA processing and modification	Spermidine synthase (polyamine aminopropyltransferase) (SpeE) (PDB:6BQ2)!!!S-adenosylmethionine decarboxylase (SpeD) (PDB:1TLU)	S-adenosylmethionine decarboxylase;Conserved hypothetical protein 95;Spermine/spermidine synthase domain;Spermidine synthase tetramerisation domain	S-adenosylmethionine decarboxylase [EC:4.1.1.50];spermidine synthase [EC:2.5.1.16]	PF02675.16;PF03602.16;PF01564.18;PF17284.3
2647	-0.09638022190032781	0.004286328956073594	-0.04701103144031945	-0.18321997981029559	0.020332757389809903	-0.06926668696760985	0.15000385798755198	0.10425817720766653	0.05072222956072879	RNA processing and modification	ABC-type amino acid transport/signal transduction system, periplasmic component/domain (HisJ) (PDB:1GGG)	Ligated ion channel L-glutamate- and glycine-binding site;Bacterial extracellular solute-binding proteins, family 3	polar amino acid transport system substrate-binding protein;octopine/nopaline transport system substrate-binding protein	PF10613.10;PF00497.21
2648	0.24686379436776504	0.10745628208380123	-0.5398798069180439	0.020915798194646878	0.1467719667979807	-0.07471882951557356	0.09532057815656471	0.2816039223746211	0.018981704625100012	RNA processing and modification	ABC-type arginine transport system, permease component (ArtQ)	Binding-protein-dependent transport system inner membrane component	octopine/nopaline transport system permease protein	PF00528.23
2649	0.02620734755036669	0.16436288365973556	-0.3760670083195134	-0.04910624780165844	0.0017438844492033768	-0.1808558371458424	-0.02947538814670673	0.3420966293455944	0.021006807264034585	RNA processing and modification	ABC-type arginine/histidine transport system, permease component (ArtM)	Binding-protein-dependent transport system inner membrane component	polar amino acid transport system permease protein	PF00528.23
2650	0.15981797572058803	0.05152158609207938	-0.1123071862938865	-0.04976853504640597	0.056324391370299064	0.037166435966752794	0.15461243565311383	0.0024727892641936027	0.11606477407906861	Function Unknown	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family (PhyH) (PDB:2A1X)	Phytanoyl-CoA dioxygenase (PhyH)	NA	PF05721.14
2651	0.2351699540524328	0.17465610667698084	-0.27355953193704924	0.040615346043421714	0.11301179702643105	-0.1101862524505559	0.07625181294152315	0.1676238673842052	0.04024435354739258	NA	NA	NA	NA	NA
2652	0.27593431314596367	0.02567342636475632	0.3085356563287396	-0.028177304280960807	0.3537730955676222	0.20335250408241085	0.150830255176714	-0.2748276139247526	0.10838392794843521	Energy production and conversion	ADP-heptose:LPS heptosyltransferase (RfaF) (PDB:1PSW)	Glycosyltransferase family 9 (heptosyltransferase)	NA	PF01075.18
2653	-0.02125851542268991	0.11114320845094997	-0.25475446674411617	0.271789499665045	-0.25227877658005887	-0.20312904847573124	0.21783908544036185	0.13481747357704457	0.10499172205229448	Carbohydrate metabolism and transport	Uncharacterized membrane protein AbrB, regulator of aidB expression (AbrB)	Transition state regulatory protein AbrB	uncharacterized protein	PF05145.13
2654	0.008865947696722233	-0.17303796030566704	0.20770982262091045	-0.00998727554400827	0.18293245052053617	-0.08749345953107922	-0.19091668532930792	-0.11363021123370741	0.08319780920115966	Amino Acid metabolis and transport	Tripartite-type tricarboxylate transporter, extracytoplasmic receptor component TctC (TctC) (PDB:2DVZ)	Tripartite tricarboxylate transporter family receptor	putative tricarboxylic transport membrane protein	PF03401.15
2656	-0.2151761806375541	0.06776587270252936	-0.05821860553044403	-0.058682359392459596	-0.28683201290755483	-0.1615545429170522	-0.09107754269769378	0.16913568019781708	0.013201798221911983	Carbohydrate metabolism and transport	TctA family transporter (PUBMED:14499931)	Tripartite tricarboxylate transporter TctA family	putative tricarboxylic transport membrane protein	PF01970.17
2657	0.3098592069274356	0.026680479967282268	-0.14918085769154527	-0.13072327961656752	0.2803775564539108	0.024074438135441127	0.0754751695392499	-0.004121471756700243	0.05138143852715916	Energy production and conversion	Permease of the drug/metabolite transporter (DMT) superfamily (RhaT) (PDB:5I20)	EamA-like transporter family	S-adenosylmethionine uptake transporter	PF00892.21
2658	0.20562265246694283	0.09743950160260312	-0.34456891591249494	-0.1274179070168355	0.1038254833594103	0.035364118027901986	0.16291655596430168	0.18672536851909702	0.07673665820938619	Energy production and conversion	Glycosyltransferase involved in cell wall bisynthesis (RfaB) (PDB:2IV7)	Glycosyl transferases group 1;Glycosyltransferase Family 4;Glycosyl transferases group 1	phosphatidyl-myo-inositol dimannoside synthase [EC:2.4.1.346]	PF00534.21;PF13439.7;PF13692.7
2659	-0.005160791661388149	0.014956120977046676	-0.24761343561642904	-0.16573640844107804	-0.010086824891395774	-0.06710720625139954	-0.024869690080339738	0.23717208619072064	0.07592849169192348	Inorganic ion transport and metabolism	Peroxiredoxin (Bcp) (PDB:5IPH)	AhpC/TSA family;Redoxin	NA	PF00578.22;PF08534.11
2660	0.16751719318872246	0.002909244423731316	-0.20791993446512358	-0.14468383884008362	0.18897524482468916	-0.09774549244936093	0.11969960640914919	0.10252284126654758	0.03304701642907673	Carbohydrate metabolism and transport	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily (PaaY) (PDB:6IVE)	Bacterial transferase hexapeptide (six repeats)	gamma-carbonic anhydrase [EC:4.2.1.-]	PF00132.25
2661	0.11379224917834377	-0.12797702739725597	-0.5983489005508735	0.2213496954761444	-0.056921168597179626	-0.0963011939730655	0.3585871924135898	0.263700770016176	0.07704024117264822	Nucleotide metabolism and transport	Uncharacterized conserved protein, DUF1330 family	Domain of unknown function (DUF1330)	NA	PF07045.12
2662	-0.20756893496054632	-0.1531936387562236	0.31130763949913826	-0.13687615722422966	-0.10501810012959201	0.12958584948628118	-0.11951569894161429	-0.15445172897755685	0.12230362664405524	NA	NA	NA	NA	NA
2663	0.23517053869765042	0.12499525161658917	-0.49181027099639724	-0.05085530901889896	0.13505100824666372	-0.06868866676230684	0.18492932790381775	0.22597909890052117	0.04460897906312445	Replication and repair	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase (MmsB) (PDB:1I36)	Pyridoxamine 5'-phosphate oxidase;Pyridoxamine 5'-phosphate oxidase	pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]	PF01243.21;PF12766.8
2664	0.14112732646296777	0.17968027008133236	-0.40378737082535143	-0.0051655916686635115	0.0897025070019635	0.03812138301722179	0.03713644519909158	0.23466594964653495	0.03158123859541091	Replication and repair	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase (MmsB) (PDB:1I36)	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain;NADP oxidoreductase coenzyme F420-dependent;NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase;NAD binding domain of 6-phosphogluconate dehydrogenase;Shikimate / quinate 5-dehydrogenase	2-hydroxy-3-oxopropionate reductase [EC:1.1.1.60];3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]	PF02737.19;PF03807.18;PF14833.7;PF03446.16;PF01488.21
2665	0.42900317420445366	-5.987104526312004e-4	-0.28955456410885155	-0.185394393454245	0.3914417629835188	0.03500885727784813	0.060479559827863974	0.05899488495021547	0.061959460460584974	Energy production and conversion	Predicted arabinose efflux permease AraJ, MFS family (AraJ) (PDB:4LDS)	Major Facilitator Superfamily	NA	PF07690.17
2666	0.3510086870405425	0.060556548685996636	-0.47494248666934746	-0.15128187760150186	0.2607073576761443	-0.06154860137483745	0.049840008648284626	0.18134375756499702	0.04385666723712685	Signal Transduction	DNA-directed RNA polymerase, subunit K/omega (RpoZ) (PDB:3LU0)	RNA polymerase Rpb6	DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	PF01192.23
2667	0.22789763625982626	0.0593130496853032	-0.11045674712136434	-0.08938273308632211	0.20641488537645278	-0.03076557830739345	0.03277023040476835	0.04579300503424849	0.03784519331187874	Signal Transduction	tRNA-dihydrouridine synthase (DusA) (PDB:1VHN)	Dihydrouridine synthase (Dus)	tRNA-dihydrouridine synthase A [EC:1.-.-.-]	PF01207.18
2668	0.28542442440058297	0.05932610807647098	-0.22870242809200408	-0.004958290782067262	0.31634763025272994	7.404689665236216e-4	0.12635646697429342	0.07187209170125543	0.04248463055415341	Lipid metabolism	Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family (TauE) (PUBMED:21183667;22797525)	Sulfite exporter TauE/SafE	uncharacterized protein	PF01925.20
2669	-0.09644704775234095	0.05555713143021107	-0.2886884723561922	0.04271607622101281	-0.09807724555813219	-0.09624940366250938	0.04374493541265951	0.2534309051264803	0.08883678082501739	NA	NA	NA	NA	NA
2671	0.3391420512412791	0.03747746713371159	-0.31770057665102847	-0.0852109728413512	0.2691552699261267	-0.022895846321209726	0.12357436402644968	0.10332326691267554	0.07115488448941101	Energy production and conversion	Phosphomannomutase (ManB) (PDB:6MNV)	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I;Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II;Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III;Phosphoglucomutase/phosphomannomutase, C-terminal domain	phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]	PF02878.17;PF02879.17;PF02880.17;PF00408.21
2672	0.38413563084509605	0.017388510500150275	-0.2696194262260426	-0.17000632368062799	0.3822907603682789	0.019428565478934227	-0.004026633964975936	0.11974830261951062	0.01993499953980111	Cell motility	Ribonucleotide reductase alpha subunit (NrdA) (PDB:1R1R)	Ribonucleotide reductase, barrel domain;Ribonucleotide reductase, all-alpha domain	ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	PF02867.16;PF00317.22
2676	0.12435853154212605	-4.6272796910163e-4	-0.07340031594885371	-0.10891006289444434	0.1743002914061852	0.060896861688227444	0.1382318535516216	0.04709790899746413	0.03295957590974754	Energy production and conversion	2-Methylisocitrate lyase and related enzymes, PEP mutase family (PrpB) (PDB:1XG3)	Isocitrate lyase family;Phosphoenolpyruvate phosphomutase	methylisocitrate lyase [EC:4.1.3.30]	PF00463.22;PF13714.7
2677	-0.2761040062263675	0.05032981987565464	0.03995731437757082	0.1827802645790123	-0.322214201290457	-0.07365514068000749	0.06819481386001029	0.13016635676243177	0.05182152562989071	Energy production and conversion	2-methylcitrate dehydratase PrpD (PrpD) (PDB:1SZQ)	MmgE/PrpD family	2-methylcitrate dehydratase [EC:4.2.1.79]	PF03972.15
2678	0.22765739564969675	0.02274170940892833	-0.1818211278562624	-0.19170082083671036	0.33007214283647657	-0.04309836382739628	-0.10794665387272395	0.16951109294323066	0.05125206522653605	Amino Acid metabolis and transport	Phosphoglycolate phosphatase, HAD superfamily (Gph) (PDB:2NYV)	haloacid dehalogenase-like hydrolase;Haloacid dehalogenase-like hydrolase;haloacid dehalogenase-like hydrolase;HAD-hyrolase-like;NLI interacting factor-like phosphatase	phosphoglycolate phosphatase [EC:3.1.3.18]	PF12710.8;PF13419.7;PF00702.27;PF13242.7;PF03031.19
2679	0.16796998353495307	0.01628965530750803	-0.07004175111499472	-0.039881517160926964	0.1391750858425349	-0.048781905947749886	0.1796267686980272	-0.016141682819321282	0.09119551366386885	Energy production and conversion	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU) (PDB:3FWW)	Bacterial transferase hexapeptide (six repeats);Hexapeptide repeat of succinyl-transferase	bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	PF00132.25;PF14602.7
2680	-0.08502093954235156	0.04497414586774655	-0.08701502817364999	0.046784995571300766	-0.03568130757471049	0.03236954327328193	0.05403199324653584	0.1426108406808403	0.047151781399305155	Energy production and conversion	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains (GlmS) (PDB:2J6H)	Glutamine amidotransferase domain;Glutamine amidotransferase domain;SIS domain	glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	PF13522.7;PF13537.7;PF01380.23
2683	-0.1032198465538071	0.06569953021902757	-0.3478680196729995	0.0837148066863335	-0.14304225626807768	-0.1272798827974184	-0.04975615364806887	0.3307087333659925	0.04752576736934409	Energy production and conversion	NH3-dependent NAD+ synthetase (NadE) (PDB:3HMQ)	NAD synthase;Queuosine biosynthesis protein QueC	NA	PF02540.18;PF06508.14
2685	0.09915400655795195	-0.004751093187764884	0.16162502658341688	-0.047504789947777876	0.09426373225291403	0.15253445272418795	0.01160534731789529	-0.1270124584620805	0.03802790043047465	RNA processing and modification	Isopropylmalate/homocitrate/citramalate synthases (LeuA) (PDB:4JN6)	HMGL-like;LeuA allosteric (dimerisation) domain	2-isopropylmalate synthase [EC:2.3.3.13]	PF00682.20;PF08502.11
2686	0.011409947392956482	0.21743559162485918	-0.1308371788856766	0.24427402602127363	-0.08681735128255517	-0.11817712632118689	0.11116753055680424	0.11515398895564737	0.07602909740604731	Signal Transduction	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase (TrmJ) (PDB:3ONP)	SpoU rRNA Methylase family	tRNA/rRNA methyltransferase [EC:2.1.1.-]	PF00588.20
2687	-0.051984876652326005	-0.039466926401221195	-0.63745805030936	0.06681026513884541	-0.11450604380659499	-0.19842624614913643	0.10500072676969034	0.41858120029429163	0.01580911201471399	Signal Transduction	Ribosomal protein S4 or related protein (RpsD) (PDB:4V4H)	Ribosomal protein S4/S9 N-terminal domain;S4 domain	small subunit ribosomal protein S4	PF00163.20;PF01479.26
2688	0.30014207879670973	0.2071178514923809	-0.13189707258816574	-0.14467102185682262	0.25867976052426506	0.029285028925594286	0.12454102705699328	0.012569776258989066	0.036058570170667784	Inorganic ion transport and metabolism	Glutaredoxin-related protein (GrxD) (PDB:1YKA)	Glutaredoxin	monothiol glutaredoxin	PF00462.25
2689	-0.07125202114948308	0.09827379740730094	-0.20049720253588305	0.20512636517012475	-0.12950863851377475	-0.02799720445528049	0.3706336557527846	0.028197397959112996	0.02381409444067542	Signal Transduction	DNA-binding global transcriptional regulator BolA, affects cell shape, cell division and biofilm formation (BolA) (PDB:2DHM) (PUBMED:19111750;2569159)	BolA-like protein	NA	PF01722.19
2690	0.415392126318808	-0.07025154251400356	0.09982390852914916	-0.174856141478329	0.3482434878282378	0.16300835817272427	0.002028665737687375	-0.18231124798320059	0.03770847452847592	Cell motility	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain (PurL1) (PDB:3VIU)	AIR synthase related protein, N-terminal domain;AIR synthase related protein, C-terminal domain;Formylglycinamide ribonucleotide amidotransferase linker domain	phosphoribosylformylglycinamidine synthase subunit PurL [EC:6.3.5.3]	PF00586.25;PF02769.23;PF18072.2
2691	0.24041854760403264	0.028284344045208392	-0.4499341814308965	-0.05963019781207024	0.12092018621584302	-0.00428822257591905	0.2290044105099711	0.20575885307404565	0.045256598564207995	Cell motility	Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain (PurL2) (PDB:1T3T)	DJ-1/PfpI family;Glutamine amidotransferase class-I;CobB/CobQ-like glutamine amidotransferase domain;CobB/CobQ-like glutamine amidotransferase domain	phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]	PF01965.25;PF00117.29;PF07685.15;PF13507.7
2692	0.15518729571127635	0.04588017315082491	0.09744643796317422	-0.23345954917471023	0.21275265224819007	-3.1824014302987756e-4	-0.008596797380580069	-0.050411329382790145	0.07743493381353564	Cell motility	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit (PurS) (PDB:1GTD)	Phosphoribosylformylglycinamidine (FGAM) synthase	phosphoribosylformylglycinamidine synthase subunit PurS [EC:6.3.5.3]	PF02700.15
2693	0.18127102666060166	-0.04366913291221463	0.03294890958580349	-0.08783450787821154	0.17697283896648797	-0.07679228051701972	-0.09114267596920227	0.002212392371524673	0.03920694511494781	Cell motility	Phosphoribosylaminoimidazole-succinocarboxamide synthase (PurC) (PDB:1A48)	SAICAR synthetase	phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	PF01259.19
2694	0.10253356714477396	0.16671360801279794	-0.12544889214267482	0.17138858956202666	-0.0189016006909571	-0.06773752770444434	0.12380075243300855	0.07518965147128855	0.048517599408478954	Cell motility	Adenylosuccinate lyase (PurB) (PDB:2HVG)	Adenylosuccinate lyase C-terminus;Lyase	adenylosuccinate lyase [EC:4.3.2.2]	PF10397.10;PF00206.21
2695	0.021006110974330368	-0.02385828589565101	-0.15660382144346294	-0.1596745277418826	0.09166258611173031	-0.08477703659809355	-0.03969959372514037	0.16380785650149035	0.049861377372051055	Signal Transduction	Methionine aminopeptidase (Map) (PDB:3J2I)	Metallopeptidase family M24	methionyl aminopeptidase [EC:3.4.11.18]	PF00557.25
2696	-0.3107334335720612	0.06138397723239141	-0.33003685688443674	0.33528303269371157	-0.3437591430778047	-0.2857793976265227	-0.0021140149813968826	0.32142585025608883	0.08168736517124618	Energy production and conversion	DNA-binding protein, stimulates sugar fermentation (SfsA) (PDB:4DA2)	Sugar fermentation stimulation protein RE domain;SfsA N-terminal OB domain	sugar fermentation stimulation protein A	PF03749.14;PF17746.2
2697	0.14752048254985786	-0.02940742332902643	-0.07198461192042287	-0.2103050642265942	0.23956303106618365	-0.03517277293104172	-0.037111893622615924	0.08271224705923749	0.058345830286749244	General Functional Prediction only	ADP-ribose pyrophosphatase domain of DNA damage- and competence-inducible protein CinA (CinA) (PDB:4CT9) (PUBMED:25313401)	Probable molybdopterin binding domain	FAD synthetase [EC:2.7.7.2]	PF00994.25
