Centers and Institutes
Published December 25, 2024 | Version v1
Journal article Open

A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation

Creators

  • 1. University of Chicago
  • 2. University of Pittsburgh
  • 3. St. Joseph's Hospital and Medical Center
  • 4. Medical College of Wisconsin
  • 5. University of Texas at Austin

Description

Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain–computer interface (BCI) to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other BCI studies to ensure the successful placement of stimulation electrodes.

Data availability

Deidentified data from this study is available on the Data Archive for the BRAIN Initiative (URL generated after acceptance).

Files

Roadmap-for-Implanting-Electrode-Arrays-to-Evoke-Tactile-Sensations-Through-Intracortical-Stimulation.pdf

Files (9.3 MB)

Additional details

Identifiers

DOI
10.1002/hbm.70118
Other
oai:uchicago.tind.io:14316

Funding

Defense Advanced Research Projects Agency
N66001-10-C-4056
National Institutes of Health
UH3 NS107714

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Computational Neuroscience, Neurological Surgery, Organismal Biology and Anatomy
Center(s) or Institute(s)
Neuroscience Institute