Centers and Institutes
Published December 13, 2011 | Version v1
Journal article Open

MicroRNA Expression Characterizes Oligometastasis(es)

Creators

  • 1. University of Chicago
  • 2. Duke University Medical Center

Description

Background: Cancer staging and treatment presumes a division into localized or metastatic disease. We proposed an intermediate state defined by ≤5 cumulative metastasis(es), termed oligometastases. In contrast to widespread polymetastases, oligometastatic patients may benefit from metastasis-directed local treatments. However, many patients who initially present with oligometastases progress to polymetastases. Predictors of progression could improve patient selection for metastasis-directed therapy.

Methods: Here, we identified patterns of microRNA expression of tumor samples from oligometastatic patients treated with high-dose radiotherapy.

Results: Patients who failed to develop polymetastases are characterized by unique prioritized features of a microRNA classifier that includes the microRNA-200 family. We created an oligometastatic-polymetastatic xenograft model in which the patient-derived microRNAs discriminated between the two metastatic outcomes. MicroRNA-200c enhancement in an oligometastatic cell line resulted in polymetastatic progression.

Conclusions: These results demonstrate a biological basis for oligometastases and a potential for using microRNA expression to identify patients most likely to remain oligometastatic after metastasis-directed treatment.

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Additional details

Identifiers

DOI
10.1371/journal.pone.0028650
Other
oai:uchicago.tind.io:10478

Funding

Ludwig Center for Metastasis Research
Center for Radiation Therapy
Chicago Tumor Institute
Dr. Lloyd Old
Mr. and Mrs. Vincent Foglia
Foglia foundation
Lung Cancer Research Foundation
Cancer Research Foundation
National Institutes of Health
K22 LM008308-04
National Institutes of Health
5UL1RR024999-04
University of Chicago
Comprehensive Cancer Center
National Center for the Multi Scale Analysis of Genomic and Cellular Networks
5U54CA121852-5

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Cancer Biology, Pathology, Radiation and Cellular Oncology, Surgery
Center(s) or Institute(s)
Comprehensive Cancer Center, Institute for Genomics and Systems Biology, Ludwig Center for Metastasis Research