Centers and Institutes
Published April 14, 2020 | Version v1
Journal article Open

Characterizing Emerging Canine H3 Influenza Viruses

Creators

  • 1. University of Rochester
  • 2. Cornell University
  • 3. University of Chicago
  • 4. Harvard University
  • 5. Emory University

Description

The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.

Data availability

All relevant data are within the manuscript and its Supporting Information files.

Files

journal.ppat.1008409.pdf

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Additional details

Identifiers

DOI
10.1371/journal.ppat.1008409
Other
oai:uchicago.tind.io:6255

Funding

National Institute of Allergy and Infectious Diseases
National Institutes of Health
P41GM103694
Department of Health and Human Services
Centers of Excellence for Influenza Research and Surveillance
HHSN272201400004C
Centers of Excellence for Influenza Research and Surveillance
HHSN272201400005C
Centers of Excellence for Influenza Research and Surveillance
HHSN272201400006C
Centers of Excellence for Influenza Research and Surveillance
HHSN272201400007C
Centers of Excellence for Influenza Research and Surveillance
HHSN272201400008C

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Medicine, Immunology
Center(s) or Institute(s)
Gwen Knapp Center for Lupus and Immunology Research