RECURRENT FUSION GENES IN HUMAN CANCERS

Fusion transcripts are provided herein. In exemplary embodiments, the fusion transcript is encoded by a nucleic acid molecule comprising a general structure A-B, wherein structure A is a portion of a gene listed in Column A of Table 1 and structure B is a portion of a gene listed in Column B of Table 1, wherein the gene listed in Column A and the gene listed in Column B are listed in the same row of Table 1, wherein structure B is located immediately 3′ to structure A. Polypeptides encoded by the fusion transcript, nucleic acid molecules encoding the fusion transcript, and nucleic acid molecules comprising the reverse complement sequence of the fusion transcript, are additionally provided. Related expression vectors, host cells, binding agents, kits, and methods of using the same are further provided herein.