Published February 3, 2011
| Version v1
Patent
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Methods and Compositions Related to Immunizing Against Staphylococcal Lung Diseases and Conditions
Creators
- 1. University of Chicago
Contributors
Patent applicant:
Description
Embodiments of the invention include methods and compositions useful in a vaccination strategy capable of neutralizing HIa to provide immunoprotection against S. aureus pneumonia. In certain aspects the invention includes a HIa with reduced toxicity, represented by a recombinant mutant form of HIa (HlaH35L) in which histidine 35 is converted to leucine, which can be used to abrogate the productive assembly of the toxin and protect a subject from staphylococcal pneumonia.
Files
US20110027265.pdf
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(2.3 MB)
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Additional details
Identifiers
- Patent application number
- US 67559708 A
- Patent number
- US 8840906 B2
- Other
- oai:uchicago.tind.io:7848
Dates
- Patent filed
-
2008-08-29