Published March 24, 2016
| Version v1
Journal article
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Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway
Creators
- 1. Fudan University
- 2. Shanghai Jiaotong University
- 3. University of Chicago
Description
Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner. We demonstrated that shizukaol D induced cells to undergo apoptosis. More importantly, shizukaol D attenuated Wnt signalling and reduced the expression of endogenous Wnt target genes, which resulted in decreased expression of β-catenin. Collectively, this study demonstrated that shizukaol D inhibited the growth of liver cancer cells by modulating Wnt pathway.
Data availability
All relevant data are within the paper and its Supporting Information files.Files
journal.pone.0152012.pdf
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Additional details
Identifiers
- DOI
- 10.1371/journal.pone.0152012
- Other
- oai:uchicago.tind.io:7453
Funding
- National Key Sci-Tech Special Project of China
- 2013ZX10002010
- National Science Foundation of China
- 81301855