Probiotic compounds from Lactobacillus GG and uses therefor

The invention provides methods and compositions for the treatment of inflammatory disorders, such as inflammatory bowel diseases (IBDs). The use of bacteria-free, probiotic-derived compounds instead of live bacteria provides a safety advantage over the use of live bacteria. In addition, the administration of isolated compounds will provide more reliable dosing, greater simplicity, and improved consistency than is found in administering probiotics, which is dependent on both establishing and maintaining bacterial colonization.