Centers and Institutes
Published December 10, 2012 | Version v1
Journal article Open

Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs

Creators

  • 1. University of Chicago
  • 2. University of Illinois at Chicago
  • 3. Memorial Sloan-Kettering Cancer Center

Description

Rationale: Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy.

Methods: We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent.

Results: Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset.

Conclusion: Oligo- and poly- metastasis are distinct entities at the clinical and molecular level.

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Additional details

Identifiers

DOI
10.1371/journal.pone.0050141
Other
oai:uchicago.tind.io:10515

Funding

Ludwig Center for Metastasis
Research Grant
Center for Radiation Therapy
Chicago Tumor Institute
Ludwig Foundation for Cancer Research
Mr. and Mrs. Vincent Foglia
Foglia Foundation
Lung Cancer Research Foundation
Cancer Research Foundation
National Institutes of Health
K22 LM008308-04
National Institutes of Health
5UL1RR024999- 04
National Institutes of Health
5P30CA014599-35
University of Illinois
Cancer Center
University of Illinois
Center for Clinical and Translational Science

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Medicine, Radiation and Cellular Oncology, Surgery
Center(s) or Institute(s)
Comprehensive Cancer Center, Ludwig Center for Metastasis Research