Project info 1

Project info 1 Experiment Date2017-05-08 Experiment ID Notebook ID Project Experimenter Protocol Timeline 0. 4. 8. 12. 16. 20. <TextAlign align="Center">WT</TextAlign> 373.2682 377.9446 456.0993 309.7784 1165.1200 143.9996 427.6862 440.5418 574.7785 445.4741 2225.2600 207.9460 455.1505 468.0430 586.9916 384.7258 2284.5600 158.7897 387.4728 410.0897 522.4484 378.7148 1381.0300 236.9315 431.9979 457.3161 561.1480 381.8602 2152.5300 153.9967 484.4026 500.7680 632.3484 393.3103 1371.2600 135.0627 723.4670 767.4819 1401.9200 707.0183 1956.3600 191.7719 597.6243 646.5848 1046.6000 567.0824 1703.7000 211.2859 493.7647 527.8096 777.2275 478.3330 1512.7700 193.5184 529.6397 568.6822 1024.2200 538.6372 1431.4800 197.5530 610.4462 643.9300 1035.9500 604.5977 1444.2200 210.4545 <TextAlign align="Center">WT-IR</TextAlign> 236.1830 202.9395 394.2207 251.8070 930.3473 107.2874 291.9583 178.9189 299.7608 383.3205 555.0529 224.3761 210.1917 201.5964 398.3893 268.3462 731.1594 145.8706 248.7094 255.3778 376.1296 233.9206 955.7775 125.3749 248.3870 243.2069 320.5793 255.7790 721.8801 96.44682 211.2068 218.3444 393.3653 210.6603 394.1957 146.4843 201.8458 205.6334 377.6470 227.1773 463.8337 115.2349 205.1576 213.1617 326.3745 210.6901 420.9887 117.7656 230.2823 219.9180 354.6226 189.7863 461.2731 99.01207 239.7890 235.1093 440.9454 235.8602 674.5767 70.95698 260.3745 296.1647 375.5280 282.1765 308.9640 29.90594 DRP1 KO 429.5973 440.1420 629.9252 359.1568 1151.0600 205.9024 386.3135 407.7049 644.9036 379.5050 1344.9900 148.7243 422.8594 432.7329 673.6870 378.3675 1285.7700 155.7212 444.9031 465.8351 832.0190 418.6373 1547.6500 165.1954 396.6949 417.5404 721.6363 386.1820 1197.0900 163.1857 483.9297 492.0422 1718.3100 755.4043 2131.8910 382.5493 598.0783 539.3484 1388.7800 652.0083 1599.2890 378.7966 373.4591 383.8073 1265.7940 372.5197 1385.7740 302.2009 518.6366 548.5364 1742.9890 711.9161 1640.4510 375.5819 548.2918 503.3267 1903.9200 861.9058 2568.3740 407.1016 DRP1 KO-IR 366.9574 371.1301 602.6488 366.0072 971.0541 171.1678 289.4353 285.5579 501.7388 305.0647 754.3730 134.7902 305.1180 305.1364 565.3377 345.9561 799.6558 148.6330 366.1975 366.0767 587.9865 341.6997 966.4935 160.2304 337.5528 328.6692 558.8770 353.0552 955.8647 148.0132 314.8958 316.4354 501.3230 308.1601 774.8268 142.9179 347.4767 361.5846 1221.1450 537.1608 1439.1520 273.8734 332.9356 350.3033 828.1550 435.5358 871.5405 292.1170 239.7694 233.8037 692.1021 437.7617 591.0407 312.5429 341.5797 311.4428 1103.3440 401.0386 1362.7030 208.0204 448.8868 471.5538 1490.0420 522.1723 1457.3970 252.9313 162.4034 175.8690 868.1476 425.4247 807.2133 187.8582

Baseline <TextAlign align="Center">WT</TextAlign> 373.2682 427.6862 455.1505 387.4728 431.9979 484.4026 377.9446 440.5418 468.0430 410.0897 457.3161 500.7680 723.4670 597.6243 493.7647 529.6397 610.4462 767.4819 646.5848 527.8096 568.6822 643.9300 <TextAlign align="Center">WT-IR</TextAlign> 236.1830 291.9583 210.1917 248.7094 248.3870 202.9395 178.9189 201.5964 255.3778 243.2069 211.2068 201.8458 205.1576 230.2823 239.7890 260.3745 218.3444 205.6334 213.1617 219.9180 235.1093 296.1647 <TextAlign align="Left">DRP1 KO</TextAlign> 429.5973 386.3135 422.8594 444.9031 396.6949 440.1420 407.7049 432.7329 465.8351 417.5404 483.9297 598.0783 373.4591 518.6366 548.2918 492.0422 539.3484 383.8073 548.5364 503.3267 <TextAlign align="Left">DRP1 KO-IR</TextAlign> 366.9574 289.4353 305.1180 366.1975 337.5528 314.8958 371.1301 285.5579 305.1364 366.0767 328.6692 316.4354 347.4767 332.9356 239.7694 341.5797 448.8868 162.4034 361.5846 350.3033 233.8037 311.4428 471.5538 175.8690

ATP ralted OCR <TextAlign align="Center">WT</TextAlign> 146.3210 129.3044 202.2658 143.7335 179.2878 239.0381 694.9000 479.5200 298.8900 485.5800 431.3500 <TextAlign align="Center">WT-IR</TextAlign> 142.41380 -83.55962 130.04320 142.20890 64.80028 182.70490 150.46970 115.68430 164.83640 205.08520 93.35142 <TextAlign align="Left">DRP1 KO</TextAlign> 270.7684 265.3986 295.3195 413.3818 335.4543 962.9059 736.7712 893.2747 1031.0730 1042.0150 <TextAlign align="Left">DRP1 KO-IR</TextAlign> 236.6416 196.6742 219.3816 246.2867 205.8218 193.1629 683.9841 392.6192 254.3404 702.3052 967.8694 442.7229

Maximal OCR <TextAlign align="Center">WT</TextAlign> 855.34 1779.78 1899.83 1002.31 1770.67 977.95 1249.34 1136.62 1034.44 892.84 839.62 <TextAlign align="Center">WT-IR</TextAlign> 678.54030 171.73240 462.81320 721.85690 466.10110 183.53540 236.65640 210.29860 271.48690 438.71650 26.78743 <TextAlign align="Center">DRP1 KO</TextAlign> 791.90 965.48 907.40 1129.02 810.91 1376.49 947.28 1013.25 928.54 1706.47 <TextAlign align="Center">DRP1 KO-IR</TextAlign> 605.0469 449.3083 453.6997 624.7938 602.8095 466.6667 901.9907 436.0046 153.2789 961.6640 935.2241 381.7887

Proton Leak WT 237.5281 225.9362 141.7834 227.8635 258.2476 515.2464 355.7965 284.8145 341.0842 394.1432 165.7788 WT-IR 144.51960 158.94430 122.47560 108.54580 159.33220 64.17605 111.94240 92.92456 90.77420 164.90320 252.27060 DRP1 KO 153.25440 230.78070 222.64630 253.44190 222.99630 372.85500 273.21170 70.31873 336.33430 454.80430 <TextAlign align="Center">DRP1 KO-IR</TextAlign> 194.8394 170.2745 197.3231 181.4694 205.0420 165.2422 263.2873 143.4188 125.2189 193.0183 269.2410 237.5665

State 3/State 4 WT 1.472341 1.290263 1.525740 1.379530 1.469512 1.607760 1.982860 1.845583 1.624867 1.901496 1.713454 WT-IR 1.565567 0.7820111 1.484610 1.607937 1.253345 1.867296 1.662345 1.549073 1.868537 1.869520 1.330826 <TextAlign align="Center">DRP1 KO</TextAlign> 1.753900 1.699328 1.780510 1.987446 1.868643 2.274689 2.130003 3.397926 2.448307 2.208966 <TextAlign align="Center">DRP1 KO-IR</TextAlign> 1.646549 1.644697 1.634131 1.720769 1.582974 1.626826 2.273332 1.901462 1.581002 2.751216 2.853544 2.040661

Complex I enzyme activity contrl vs DRP1KO <TextAlign align="Left">WT</TextAlign> 1.822974 0.4064432 1.121054 0.6495282 DRP1KO 5.826229 8.511552 9.444517 10.060200

Complex I enzyme activity contrl IR vs DRP1KO IR <TextAlign align="Left">WT-IR</TextAlign> 0.09059801 1.175540 1.315859 1.418003 DRP1KO-IR 2.131893 2.353034 2.945320 3.107614