Published May 6, 2010
| Version v1
Patent
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CONTROL OF GROWTH AND REPAIR OF GASTRO-INTESTINAL TISSUES BY GASTROKINES AND INHIBITORS
Creators
- 1. University of Chicago
Contributors
Patent applicant:
Description
A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease, mucositis, and gastric ulcers.
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Additional details
Identifiers
- Patent application number
- US 60460909 A
- Patent number
- US 2010/0113356 A1
- Other
- oai:uchicago.tind.io:9323
Dates
- Patent filed
-
2009-10-23