Physical Sciences Division
Published August 24, 2021 | Version v1
Patent Open

Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles

Creators

  • 1. City of Hope
  • 2. University of Illinois at Chicago
  • 3. University of Chicago

Contributors

Description

A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.

Files

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Additional details

Identifiers

Patent number
US 11097014 B2
Patent application number
US 201716310104 A
Other
oai:uchicago.tind.io:7347

Dates

Patent filed
2017-06-14

UChicago Information

Division(s)
Physical Sciences Division
Department(s)
Computer Science