Published May 9, 2023 | Version v1
Journal article Open

Robust morphogenesis by chaotic dynamics

  • 1. University of Chicago
  • 2. Russian Academy of Sciences
  • 3. Open University
  • 4. Université de Lille

Description

This research illustrates that complex dynamics of gene products enable the creation of any prescribed cellular differentiation patterns. These complex dynamics can take the form of chaotic, stochastic, or noisy chaotic dynamics. Based on this outcome and previous research, it is established that a generic open chemical reactor can generate an exceptionally large number of different cellular patterns. The mechanism of pattern generation is robust under perturbations and it is based on a combination of Turing's machines, Turing instability and L. Wolpert's gradients. These results can help us to explain the formidable adaptive capacities of biochemical systems.

Data availability

All data generated or analyzed during this study are included in this published article and its supplementary information files.

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Additional details

Identifiers

DOI
10.1038/s41598-023-34041-x
Other
oai:uchicago.tind.io:5902

Funding

National Institutes of Health
2R01 OD010936
National Science Foundation
Division of Physics
Natural Science Foundation
DMS-1929348
Natural Science Foundation
PHY-1748958
Gordon and Betty Moore Foundation
2919.02
Kavli Foundation
Ministry of Science and Higher Education of the Russian Federation
075-15-2022-291

UChicago Information

Division(s)
Biological Sciences Division, Physical Sciences Division
Department(s)
Ecology and Evolution, Molecular Genetics and Cell Biology, Statistics