Published May 9, 2023
| Version v1
Journal article
Open
Robust morphogenesis by chaotic dynamics
- 1. University of Chicago
- 2. Russian Academy of Sciences
- 3. Open University
- 4. Université de Lille
Description
This research illustrates that complex dynamics of gene products enable the creation of any prescribed cellular differentiation patterns. These complex dynamics can take the form of chaotic, stochastic, or noisy chaotic dynamics. Based on this outcome and previous research, it is established that a generic open chemical reactor can generate an exceptionally large number of different cellular patterns. The mechanism of pattern generation is robust under perturbations and it is based on a combination of Turing's machines, Turing instability and L. Wolpert's gradients. These results can help us to explain the formidable adaptive capacities of biochemical systems.
Data availability
All data generated or analyzed during this study are included in this published article and its supplementary information files.Files
Robust-morphogenesis-by-chaotic-dynamics.pdf
Files
(2.4 MB)
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Supplementary information md5:a1a71e77eef3d308613af716e95885dd |
726.4 kB | Preview Download |
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Article md5:80471a31d42be1f276c9b0543469a6b5 |
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Additional details
Identifiers
- DOI
- 10.1038/s41598-023-34041-x
- Other
- oai:uchicago.tind.io:5902
Funding
- National Institutes of Health
- 2R01 OD010936
- National Science Foundation
- Division of Physics
- Natural Science Foundation
- DMS-1929348
- Natural Science Foundation
- PHY-1748958
- Gordon and Betty Moore Foundation
- 2919.02
- Kavli Foundation
- Ministry of Science and Higher Education of the Russian Federation
- 075-15-2022-291