Published January 30, 2020 | Version v1
Patent Open

METHOD FOR HIGHLY SENSITIVE DNA METHYLATION ANALYSIS

Description

Methods, compositions and kits are provided to amplify the amount of genomic methylated DNA can by subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.

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Additional details

Identifiers

Patent application number
US 201816491278 A
Patent number
US 2020/0032330 A1
Other
oai:uchicago.tind.io:8100

Dates

Patent filed
2018-03-08

UChicago Information

Division(s)
Physical Sciences Division
Department(s)
Chemistry