Biological Sciences Division
Published May 21, 2013 | Version v1
Journal article Open

Impact of PSCA Variation on Gastric Ulcer Susceptibility

Creators

  • 1. University of Tokyo
  • 2. Aichi Cancer Center Research Institute
  • 3. The Institute of Physical and Chemical Research
  • 4. University of Chicago

Description

Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10−7) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.

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Additional details

Identifiers

DOI
10.1371/journal.pone.0063698
Other
oai:uchicago.tind.io:10763

Funding

Ministry of Education, Culture, Sports, Science and Technology of Japan
Priority Areas of Cancer
Ministry of Education, Culture, Sports, Science and Technology of Japan
Innovative Areas
Ministry of Health, Welfare and Labours of Japan
H24-3-G002
Ministry of Health, Welfare and Labours of Japan
H23-Application(cancer)-G002

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Medicine, Surgery