Biological Sciences Division
Published March 29, 2016 | Version v1
Patent Open

Bacterial glycolipid activation of CD1d-restricted NKT cells

Creators

  • 1. Brigham Young University
  • 2. University of Chicago
  • 3. Scripps Research Institute

Contributors

Description

Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.

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Additional details

Identifiers

Patent application number
US 81410306 A
Patent number
US 9295722 B2
Other
oai:uchicago.tind.io:9502

Dates

Patent filed
2006-01-26

UChicago Information

Division(s)
Biological Sciences Division
Department(s)
Immunology, Pathology, Medicine