Scalable, large-area optical sensing platform with compact light delivery and imaging system

An optode has a planar radiation guiding medium having a first planar surface and a second planar surface and one or more perimeter surfaces bounded by the first and second planar surfaces. An excitation energy source of the optode is configured to output into the radiation guiding medium first energy at a wavelength selected to excite a fluorophore. The optode also includes a photodetector configured to image at least a portion of the first planar surface of the radiation guiding medium by detecting second energy transmitted through the radiation guiding medium.